Guest guest Posted October 16, 2004 Report Share Posted October 16, 2004 Hi Everyone, I have a question: Since Lactate dehydrogenase converts pyruvate to lactate in the final step of the glycolytic pathway, then why is my Pyruvate always lower than or just at the beginning of the the numbers listed in the " Normal Range " for that blood test?? I always( every time I have the test done) have low levels or levels below the normal range of Pyruvate, but my Lactate is always High. It hasn't been normal or even near the normal range in years. It seems like my Lactate Dehydrogenase is converting too much of my pyruvate to lactate, and not saving enough of the pyruvate. Any thoughts, ideas, or anyone know what is happening here? Thanks in advance!! Thanks Ann-Marie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 18, 2004 Report Share Posted October 18, 2004 My mito defect is thought to be a transport defect and I was told that in that case, all the deficiencies they found in the complexes are secondary, not primary. The mutation is in the gene encoding the HSPs (heat shock proteins). But this stuff gets very complicated. I'll let the experts figure it out. B > From what I understand (this may be flawed), that the defects can be in the > transport genes or other places which help to get the fuel across the > mitochondrial membrane. > > laurie > > > From: " wheatchild2 " > > Reply-To: > > Date: Sun, 17 Oct 2004 19:05:45 -0000 > > To: > > Subject: Re: Low Pyruvate levels > > > > > > > > > > > >> Pyruvate is actually sold as a (costly) supplement, but I haven't > >> tried it. > > > > I haven't tried it, but there are some forms of creatine that > > contain pyruvate. > > > > > >> A somewhat related question - is an OXPHOS defect specifically in > > one > >> of the 5 mitochondrial complexes, or is there a more or less > > specific > >> definition? What mitochondrial diseases are not considered OXPHOS? > >> > >> I know that OXPHOS is oxidative phosphorylation, so I guess maybe > >> something that is not OXPHOS happens before or after oxidative > >> phosphorylation (but still in mitochondria)? > > > > > > My understanding is that OXPHOS = electron transport chain (ETC) = > > mitochondrial respiratory chain = complexes I, II, III, IV, V. This > > is one of several metabolic cycles that are involved in > > mitochondrial metabolism. So yes, an OXPHOS defect refers to a > > defect in one of the five complexes. > > > > Beta oxidation is another metabolic cycle that is part of > > mitochondrial metabolism. I know there are others, but haven't > > looked at the diagrams recently, so will let someone else name them > > all. Biochemistry was never my favorite hobby. > > > > Take care, > > Barbara > > > > > > > > > > > > > > Medical advice, information, opinions, data and statements contained herein > > are not necessarily those of the list moderators. The author of this e mail is > > entirely responsible for its content. List members are reminded of their > > responsibility to evaluate the content of the postings and consult with their > > physicians regarding changes in their own treatment. > > > > Personal attacks are not permitted on the list and anyone who sends one is > > automatically moderated or removed depending on the severity of the attack. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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