Zithromax Online, Description, Chemistry, Ingredients - Azithromycin - RxList Monographs ... e

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e;

The OTOtoxic antibiotics are the aminoglcosides. Zithromax

does not appear to be an aminoglycoside. It is also important to note that

aminoglycoside ototoxicity applies ONLY to Mito folks with a very specific

deletion ... so does NOT apply to ALL of us! Generally speaking, it is probably

a good idea to avoid using aminoglycosides if you can. They tend to be pretty

potent antibiotics, so are prescribed for pretty stubborn infections ....

so in some cases it is a judgement call weighing the risks!!!!!

That being said ..... I would ask your doctor and your pharmacist if an antibiotic

you are prescribed falls into this class. Perhaps even print this out and

have your pharmacist post the possibility of ototoxicity on your file on

his computer.

Jean

http://www.rxlist.com/cgi/generic/azith.htm

Azithromycin

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DESCRIPTION

Zithromax (azithromycin tablets, azithromycin

capsules and azithromycin for oral

suspension) contain the active ingredient

azithromycin, an azalide, a subclass

of macrolide antibiotics,

for oral administration. Azithromycin

has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[ (2,6-dideoxy-3-C-methyl-3-O -methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10- trihydroxy-3,5,6,8,10,12,14-heptamethyl-11- [[3,4,6-trideoxy-3-(dimethylamino)-b-D- xylo-hexopyranosyl]oxy]-1-oxa-6- azacyclopentadecan-15-one.

Azithromycin is derived from erythromycin; however, it differs chemically

from erythromycin in

that a methyl-substituted nitrogen

atom is incorporated into the

lactone ring. Its molecular formula

is C38H72N2O12, and its molecular

weight is 749.00.

Azithromycin, as the dihydrate, is a white

crystalline powder

with a molecular formula of

C38H72N2O12•2H2O

and a molecular weight of 785.0.

Zithromax is supplied for oral

administration as film-coated,

modified capsular shaped tablets containing azithromycin

dihydrate equivalent to

250 mg azithromycin and

the following inactive ingredients: dibasic

calcium phosphate anhydrous, pregelatinized starch, sodium

croscarmellose, magnesium stearate, sodium

lauryl sulfate, hydroxypropyl methylcellulose, lactose, titanium dioxide,

triacetin and D & C red

#30 aluminum lake.

Zithromax capsules contain azithromycin

dihydrate equivalent to

250 mg of azithromycin. The capsules are supplied in red

opaque hard-gelatin capsules

(containing FD & C red #40).

They also contain the following inactive ingredients: anhydrous

lactose, corn starch, magnesium

stearate, and sodium lauryl

sulfate.

It is also supplied as a powder

for oral suspension.

Zithromax for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate; tribasic; anhydrous; hydroxypropyl cellulose; xanthan gum; FD & C red #40; and spray dried artificial cherry, creme de vanilla and banana flavors. After constitution, each 5 ml of suspension contains 100 mg or 200 mg of azithromycin.

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This Page Last Revised 09/18/03