mito-dad

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I believe my two sisters and I inherited mito from our Dad....He had ptosis & Chronic progressive external ophthalmoplegia as we three girls have......My Dad and his brothers had a lots of the mito symptoms........My Mother (or any of her brothers or sisters) had no mito symptoms and she was relatively healthy until she fell at 93 yrs. and broke her hip. She died from complications of the surgery to repair it.

I think it is rare, but I think it happens.

If the defect that is causing the mito is in the nuclear DNA and then eitherparent can pass it on.

Autosomal Dominant Inheritance

Autosomal dominant inheritance may be familiar to some readers as the inheritance pattern in the non-mitochondrial disorders of Huntington disease and familial hypercholestrolemia. Among mitochondrial disorders, a rare form of Kearns-Sayre syndrome is autosomal dominant in inheritance.

With dominant inheritance, only one copy of the defective gene is required in order to develop the associated disorder. This means that each person with the disorder has a 50/50 chance of passing on the gene to any children they may have. Additionally, any child that inherits the defect may develop the disorder and in turn have a 50/50 chance of passing on the defective gene. However, with one normal and one mutated gene, all of these individuals may or may not develop symptoms of disease. If they do develop disease, the severity can vary markedly. In regards to the highly variable manifestations among individuals with a defective gene, autosomal dominant and maternally inherited mitochondrial disorders are similar. However, in autosomal dominant, but never in maternally inherited, conditions boys can pass the defective gene and disease to their children.

Message: 10 Date: Thu, 08 Jan 2004 05:08:46 -0000 Subject: Re: Mito inherited from father?-I believe that mitochondria are inherited only from the mother.http://www.mostgene.org/gd/gdvol10b.htmMitochondria are passed from generation to generation only through maternal egg cells where they are abundant. Those present in sperm are concentrated in the tail and do not contribute to the compliment of the fertilized zygote. Molecular genetic tracking of polymorphic or variable regions through families and even across the millenia of human evolution confirm maternal inheritance of mitochondrial DNA. http://www.genetics.com.au/Genetics2004/FactSheets/8.aspCAN MUTATIONS IN THE MITOCHONDRIAL GENES BE INHERITED? The number of mitochondria in every cell of a person's body varies from a few to hundreds. All of these mitochondria, and therefore the DNA within the mitochondria, descend from the small number of mitochondria present in the original egg cell at the time of that person's conception. The sperm does not contribute any mitochondria to the baby. Thus an individual's mitochondria are only inherited from his or her mother. An abnormality in one of the mitochondrial genes can therefore be passed by the mother in her egg cells. As most of the mother's egg cells carry the same mitochondrial mutation, the risk of this mother having another affected child with the mitochondrial disorder is high.