Guest guest Posted December 31, 2004 Report Share Posted December 31, 2004 Debra, Wow! I find it very odd that no doctor thought the " chronic acute inflammation " seen in your muscle tissue was odd. Blows me away, in fact. Would a rheumatologist find it interesting enough to pursue further? It would seem to fit their bailiwick anyway. I know my rheumy would pay attention to such a finding. At the moment I can't recall any reports where chronic acute inflammation was seen in muscle of a mito patient, but it may well occur. In one study of the muscle biopsies of 113 mito patients, there were histological abnormalities in 65 cases, the most common being angular atrophic esterase-positive muscle fibers, type II muscle atrophy, regenerating muscle fibers and scattered cytochrome-oxidase (COX) deficient fibers. 54 specimens had increased numbers of mitochondria. 8 specimens had increased mitochondrial size and 3 specimens had paracrystalline mitochondrial inclusions. 3 specimens had ragged red fibers. Other findings included increased glycogen deposition, focal Z-band streaming and increased lipid accumulation. Specific histologic findings suggestive of mitochondrial abnormalities (COX-deficient fibers, ragged red fibers) were noted in a minority of cases. However, ultrastructural evidence of mitochondrial abnormalities was noted in the majority of cases. Barbara _____ From: Debra Beckmann Sent: Friday, December 31, 2004 8:03 AM To: Subject: muscle biopsy? In the posts about muscle biopsy I read someone, I think Laurie had " chronic mild inflammation " . I had a fresh and fixed biopsy done in 2002 and even though I have been on oral prednisone since 1997 it showed " chronic acute inflammation " yet no one thought that was odd but me. There were no red ragged fibers but other than the two specific disorders they were looking for nothing else was noted, or tested. Debra Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 31, 2004 Report Share Posted December 31, 2004 Debra Only one of my many showed the inflammation, at least that was the only one mentioned. Having the correct tests run by an experienced lab is the key to good results. laurie > > Reply-To: > Date: Fri, 31 Dec 2004 08:03:10 -0600 > To: > > Subject: muscle biopsy? > > In the posts about muscle biopsy I read someone, I think Laurie had " chronic > mild inflammation " . I had a fresh and fixed biopsy done in 2002 and even > though I have been on oral prednisone since 1997 it showed " chronic acute > inflammation " yet no one thought that was odd but me. There were no red > ragged fibers but other than the two specific disorders they were looking for > nothing else was noted, or tested. > > Debra > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 31, 2004 Report Share Posted December 31, 2004 Barbara, Thanks for posting that information about the biopsies. I had posted about the chronic inflammation and rare foci, interestingly enough the info you attached mentioned increased lipid production. That is exactly what mine said as well. I remember asking Dr Cohen if that meant my thigh was " exceptional fat " :-) Of course he assured me that was not the meaning of increased lipid production. I have wondered about the chronic inflammation and if anyone else had the same findings. I called Dr Cohen's office earlier this week on the request of my PT who was wondering if there was anything else he could be doing to help my case. I was told that Dr Cohen was out until Monday. I didn't expect a call back. I got a call yesterday from Fran his Secretary. He had called in for messages and he asked her to call me back with this information. " Apparently most patients with progressive muscle disease experience similar problems with neck and back pain. He told me that the PTs usually know better what each patient needs but if mine needed to speak to him he was available. He also told me that it the condition worsened that I could come to CCF and see him. " Let's hope that it gets better not worse ! I hope that we all have a Healthy Happy New Year! Thanks to for the beautiful card. Hugs, > Debra, Wow! I find it very odd that no doctor thought the " chronic acute > inflammation " seen in your muscle tissue was odd. Blows me away, in fact. > Would a rheumatologist find it interesting enough to pursue further? It > would seem to fit their bailiwick anyway. I know my rheumy would pay > attention to such a finding. > > > > At the moment I can't recall any reports where chronic acute inflammation > was seen in muscle of a mito patient, but it may well occur. In one study of > the muscle biopsies of 113 mito patients, there were histological > abnormalities in 65 cases, the most common being angular atrophic > esterase-positive muscle fibers, type II muscle atrophy, regenerating muscle > fibers and scattered cytochrome-oxidase (COX) deficient fibers. 54 specimens > had increased numbers of mitochondria. 8 specimens had increased > mitochondrial size and 3 specimens had paracrystalline mitochondrial > inclusions. 3 specimens had ragged red fibers. Other findings included > increased glycogen deposition, focal Z-band streaming and increased lipid > accumulation. Specific histologic findings suggestive of mitochondrial > abnormalities (COX-deficient fibers, ragged red fibers) were noted in a > minority of cases. However, ultrastructural evidence of mitochondrial > abnormalities was noted in the majority of cases. > > > > Barbara > > > > > > > > > > > > _____ > > From: Debra Beckmann [mailto:beckmann@h...] > Sent: Friday, December 31, 2004 8:03 AM > To: > Subject: muscle biopsy? > > > > In the posts about muscle biopsy I read someone, I think Laurie had " chronic > mild inflammation " . I had a fresh and fixed biopsy done in 2002 and even > though I have been on oral prednisone since 1997 it showed " chronic acute > inflammation " yet no one thought that was odd but me. There were no red > ragged fibers but other than the two specific disorders they were looking > for nothing else was noted, or tested. > > Debra > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 1, 2005 Report Share Posted January 1, 2005 , Dr. Cohen's response to the neck and back pain as typical of progressive myopathy certainly confirms what I hear from various patients with many different muscle disorders. Also, my new neuro nodded (as if in recognition) when I mentioned these problems to him. Doesn't make the pain less, but is still strangely comforting to know that this is " the norm " for these disorders and that others do learn to cope. Yes, the increased lipid, which was marked in my case, was an important clue in my first biopsy way back in " 83. They showed me the slides, which I must admit looked quite gross to me at the time. Yuck! All those microscopic clumps of fat. That alone prompted the pathologist to send my tissue to DiMauro, who made the initial diagnosis. I've never had any microscopic signs of inflammation, however. B _____ From: mitomomtoo Sent: Friday, December 31, 2004 7:56 PM To: Subject: Re: muscle biopsy? Barbara, Thanks for posting that information about the biopsies. I had posted about the chronic inflammation and rare foci, interestingly enough the info you attached mentioned increased lipid production. That is exactly what mine said as well. I remember asking Dr Cohen if that meant my thigh was " exceptional fat " :-) Of course he assured me that was not the meaning of increased lipid production. I have wondered about the chronic inflammation and if anyone else had the same findings. I called Dr Cohen's office earlier this week on the request of my PT who was wondering if there was anything else he could be doing to help my case. I was told that Dr Cohen was out until Monday. I didn't expect a call back. I got a call yesterday from Fran his Secretary. He had called in for messages and he asked her to call me back with this information. " Apparently most patients with progressive muscle disease experience similar problems with neck and back pain. He told me that the PTs usually know better what each patient needs but if mine needed to speak to him he was available. He also told me that it the condition worsened that I could come to CCF and see him. " Let's hope that it gets better not worse ! I hope that we all have a Healthy Happy New Year! Thanks to for the beautiful card. Hugs, > Debra, Wow! I find it very odd that no doctor thought the " chronic acute > inflammation " seen in your muscle tissue was odd. Blows me away, in fact. > Would a rheumatologist find it interesting enough to pursue further? It > would seem to fit their bailiwick anyway. I know my rheumy would pay > attention to such a finding. > > > > At the moment I can't recall any reports where chronic acute inflammation > was seen in muscle of a mito patient, but it may well occur. In one study of > the muscle biopsies of 113 mito patients, there were histological > abnormalities in 65 cases, the most common being angular atrophic > esterase-positive muscle fibers, type II muscle atrophy, regenerating muscle > fibers and scattered cytochrome-oxidase (COX) deficient fibers. 54 specimens > had increased numbers of mitochondria. 8 specimens had increased > mitochondrial size and 3 specimens had paracrystalline mitochondrial > inclusions. 3 specimens had ragged red fibers. Other findings included > increased glycogen deposition, focal Z-band streaming and increased lipid > accumulation. Specific histologic findings suggestive of mitochondrial > abnormalities (COX-deficient fibers, ragged red fibers) were noted in a > minority of cases. However, ultrastructural evidence of mitochondrial > abnormalities was noted in the majority of cases. > > > > Barbara > > > > > > > > > > > > _____ > > From: Debra Beckmann [mailto:beckmann@h...] > Sent: Friday, December 31, 2004 8:03 AM > To: > Subject: muscle biopsy? > > > > In the posts about muscle biopsy I read someone, I think Laurie had " chronic > mild inflammation " . I had a fresh and fixed biopsy done in 2002 and even > though I have been on oral prednisone since 1997 it showed " chronic acute > inflammation " yet no one thought that was odd but me. There were no red > ragged fibers but other than the two specific disorders they were looking > for nothing else was noted, or tested. > > Debra > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2006 Report Share Posted July 27, 2006 No, I have never had a muscle biopsy. However, I did have a nerve biopsy from my calf muscle in my left leg. Parts of my sural nerve was removed to see if sarcoid was present. The results were negative and the surgery was a piece of cake. No problemo! I wish you the same my dear friend. Brother Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.