MetroTriplets Don't Abate UVB Redness

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Hi,

Below is a recent article regarding the MetroTriplets and sun-induced

redness.

Take care,

Matija

Topical Metronidazole Does Not Abate UVB-Induced Erythema [Record

Supplied By Aries Systems]

Dermatology 2001;203(2):121-123 (ISSN: 1018-8665)

Guarrera M; Brusati C; Rebora A [Find other articles with these

Authors]

Abstract Background: The capacity of topical metronidazole to reduce

erythema severity scores in rosacea has been attributed to its

anti-inflammatory activity. Methods: Nine healthy subjects were

irradiated

on three 1-cm2 areas on their volar forearm with 2 MEDs of UVB.

Twenty-four hours later, one of the irradiated areas was treated daily

with metronidazole 1% vanishing cream, one with the vehicle only and

the third was left untreated (control). The intensity of erythema was

measured, at 24, 48, 72 and 96 h after irradiation, by a Chromameter

CR200 (Minolta, Japan) and expressed in the L*a*b* system. The

a* parameter was taken as the measure of redness. Results: Overall,

redness diminished over time in a linear way, but treatments did not

influence it significantly. Conclusion: In our vehicle, metronidazole

1%

cream failed to abate the UVB-induced erythema. An activity other than

the anti-inflammatory one should be suggested to explain the topical

metronidazole efficacy in rosacea. Copyright © 2001 S. Karger

AG, Basel [Copyright Information: ©2001 by S. Karger AG, Basel]

Language: English