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Re: T2D multifactorial

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Catching up on some reading I found the following paragraphs in an article

from www.DiabetesinControl.com

(T2D = Type 2 Diabetes)

" T2D is a multifactorial disease in which environmental triggers, such as

diet and obesity, interact with genetic variants to make up an individual's

predisposition to the disease. The disease, mainly found in adults but

increasingly common in children, is characterized by impaired insulin

secretion and insulin action in tissues such as muscle and liver. Many

patients with a genetic predisposition to T2D also have a tendency to gain

weight. "

and

" " It was therefore encouraging to see that polymorphisms in some genes

previously shown to be associated with T2D in case-control studies

(particularly P12A in the PPARG and SNP44 in the CAPN10 genes) could predict

T2D in high-risk individuals from families with T2D, " they wrote. "

http://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=3242

Bea

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