Abstract - The response to local anaesthetics (EMLA-cream) as a clinical test to diagnose between hypermobility and Ehlers Danlos type III syndrome

[Guest guest]

L Arendt-Nielsen, S Kaalund, B Hogsaa, P Bjerring, and C Grevy

The response to local anaesthetics (EMLA-cream) as a clinical test to

diagnose between hypermobility and Ehlers Danlos type III syndrome.

Scand J Rheumatol, January 1, 1991; 20(3): 190-5.

To make a differential diagnosis of Ehlers Danlos (EDS) Type III syndrome

and Hypermobile patients has been difficult. In genetic advising and

prognosis of the EDS patients there are need for new tools to separate them

from hypermobile patients. Topical analgesics (EMLA cream) was applied to

seven EDS patients, ten hypermobile patients, and to fifteen controls. The

analgesic efficacy of cutaneous analgesia was evaluated by sensory and pain

thresholds to brief argon laser stimuli, and the depth of the cutaneous

analgesia was measured by sensory and pain threshold depth to controlled

needle insertions. Controls and hypermobiles did not differ in their

response to cutaneous analgesia. The thresholds to cutaneous laser

stimulation and the depth of analgesia increased significantly less in the

Ehlers Danlos patients compared to the other two groups. In clinical

practice a needle insertion test can easily be applied to investigate if

patients are responders or non-responders to local analgesics.

[Guest guest]

THANK YOU JILL!!! Have you been reading past posts about us naughty

girls at the conference who are getting tattoos???? LOL! I

appreciate the post!

Love Lana