Guest guest Posted May 12, 2004 Report Share Posted May 12, 2004 > Hi.. just wondered if anyone has used transdermal DMPS? > Thanks > I was wondering the same thing it was developed by a D.O. near Charlotte NC Dr Rashid Buttar (sp?) he has done previos research in growth factors in cancers and was supposed to be testifying before congress soon. Without speaking for Andy I am sure he would want to know if drug kinetic studies had been done before thinking it was a reasonable alternative and I have not seen these. I was thinking of calling Dr Buttar, you can search his name on the web and it will come up Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 12, 2004 Report Share Posted May 12, 2004 There are many reasons this is not a reasonable idea. 1. DMPS (and DMSA) degrade by air oxidation in solution QUICKLY unless quite acid. Any transdermal formulation will contain some water and the likelihood that there is any active left at the point it is applied to the skin is small. 2. Lipophilic molecules that cross cell membranes are well absorbed transdermally, hydrophilic ones that do not cross cell membranes are poorly absorbed. DMPS (and DMSA) are hydrophilic and lipophobic. Transdermal absorption would be expected to be poor even if there was any active in the preparation at the time it was applied. 3. DMPS is known by direct measurement in human beings to be well absorbed on oral administration (as is DMSA), with 50-60% absorption being typical (and for DMSA it is 23-25%). There is no reason for transdermal use - or injections, either for that matter. 4. The protocol I understand based on second hand descriptions that Dr. Buttar uses is neither pharmacologically nor kinetically appropriate. The most likely reason for the lack of reported adverse reactions is the lack of any active chelator actually making it into anyone's bloodstream. A lot of the atmospherics of his study also raise my hackles, e. g. I do believe the study is inappropriate chelation plus hyperbaric oxygen, both of which are known not to benefit every single autistic child, yet I do believe this claim is made. I have only second hand knowledge so it is possible that the study design is more well thought out than I understand, but I do believe that the study is to include children on the diagnosis of autism, rather than on some other biochemically appropriate parameter, and to treat them all with both HBOT AND a novel, unproven and unstudied form of chelation at the same time. This does not strike me as an experiment where it will be possible to figure out why it worked or didn't work, regardless of outcome. If anyone can get Dr. Buttar's general discussion of these issues I'd certainly be fascinated to hear it. Andy . . .. . . . . . . . . . . . . .. > > Hi.. just wondered if anyone has used transdermal DMPS? > > Thanks > > > > > I was wondering the same thing it was developed by a D.O. near > Charlotte NC Dr Rashid Buttar (sp?) he has done previos research in > growth factors in cancers and was supposed to be testifying before > congress soon. Without speaking for Andy I am sure he would want to > know if drug kinetic studies had been done before thinking it was a > reasonable alternative and I have not seen these. I was thinking of > calling Dr Buttar, you can search his name on the web and it will > come up Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 12, 2004 Report Share Posted May 12, 2004 I know two people who are using it with their son. Their doc is in Asheville, NC, and recently could not get the transdermal DMPS, something to do with the mfg of it. One friend has seen her son's mercury level go down, was already below normal in the beginning. She knows for a fact she was exposed to mercury while pregnant from a facility that was housing mercury. Her son is improving developmentally, but it cannot be contributed for certain to the DMPS. The other friend has seen her son's mercury level slightly higher. He is improving developmentally, also. Again, no way to know if it's from the DMPS and he was improving prior to beginning. They both used hair analysis to determine the mercury levels to which I refer. Debi > Hi.. just wondered if anyone has used transdermal DMPS? > Thanks > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 12, 2004 Report Share Posted May 12, 2004 I was wondering what transdermal chelator he was using... Why TD vs oral? Does it cause gut bug flair-up? If you call, fill us in on what you find out. [ ] Re: Transdermal DMPS? > > > Hi.. just wondered if anyone has used transdermal DMPS? > > Thanks > > > > > I was wondering the same thing it was developed by a D.O. near > Charlotte NC Dr Rashid Buttar (sp?) he has done previos research in > growth factors in cancers and was supposed to be testifying before > congress soon. Without speaking for Andy I am sure he would want to > know if drug kinetic studies had been done before thinking it was a > reasonable alternative and I have not seen these. I was thinking of > calling Dr Buttar, you can search his name on the web and it will > come up > > > > ======================================================= > Quote Link to comment Share on other sites More sharing options...
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