Re: Reprint Article - Chronic Fatigued Often Paired With Ehlers-Danlos Syndrome

[Guest guest]

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

[Guest guest]

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

[Guest guest]

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

[Guest guest]

exactly!!!

Re: Reprint Article - Chronic Fatigued Often Paired With

Ehlers-Danlos Syndrome

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

To learn more about EDS, visit our website: http://www.ehlersdanlos.ca

[Guest guest]

exactly!!!

Re: Reprint Article - Chronic Fatigued Often Paired With

Ehlers-Danlos Syndrome

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

To learn more about EDS, visit our website: http://www.ehlersdanlos.ca

[Guest guest]

exactly!!!

Re: Reprint Article - Chronic Fatigued Often Paired With

Ehlers-Danlos Syndrome

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

To learn more about EDS, visit our website: http://www.ehlersdanlos.ca

[Guest guest]

Mike: I must have missed a message or two here. I did not see the

above mentioned article. Could you forward it to me. For some reason

my husbands messages were coming in on my side of the computer and he

had quite the large collection, think the box was filled. Have cleared

those. Bernie

Re: Reprint Article - Chronic Fatigued Often Paired With

Ehlers-Danlos Syndrome

Jill -

Interesting article, particularly the following line:

" According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. "

That certainly is not " rare " by any definition I would use.

Mike

To learn more about EDS, visit our website: http://www.ehlersdanlos.ca

[Guest guest]

I must have missed a message or two here. I did not see the above

mentioned article. Could you forward it to me.

---------------------------------

Chronic Fatigued Often Paired With Ehlers-Danlos Syndrome

Bruce Jancin, Denver Bureau

[Pediatric News 33(3):40, 1999. © 1999 International Medical News

Group.]

Denver -- Chronic fatigue syndrome appears to be common among

patients with Ehlers-Danlos syndrome, a connective tissue disorder

characterized by joint hypermobility, hyperelastic skin, and

connective tissue fragility.

Orthostatic intolerance is seen in both conditions, presumably

because connective tissue abnormalities predispose to excessive

venous pooling during upright posture. This explanation makes the

observed association biologically plausible, Dr. T. Geraghty

said at the annual meeting of the American Society of Human Genetics.

According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. Other

manifestations of the disorder may include acrocyanosis when limbs

are in a dependent position, wide papyraceous scarring over bony

prominences, ocular lesions, easy bruisability, and other vascular

abnormalities.

It's too early to say how often the two conditions coexist, however,

said Dr. Geraghty of s Hopkins University, Baltimore.

Dual-diagnosis patients may obtain symptomatic improvement using

medications that address orthostatic intolerance by reducing venous

pooling. Moreover, establishing the diagnosis of Ehlers-Danlos

syndrome has added benefits, including a heightened awareness of

potentially serious complications, improved detection of affected

relatives, and avoidance of unnecessary diagnostic and surgical

procedures.

Dr. Geraghty reported on 10 patients averaging 16 years of age who

were evaluated both in the Hopkins chronic fatigue syndrome clinic

and the genetics clinic. All met prevailing diagnostic criteria for

both disorders. Diagnosis of chronic fatigue syndrome preceded that

of Ehlers-Danlos by a median of 42 months in 9 of 10 patients.

The medical literature has historically underemphasized the easy

fatiguability of patients with Ehlers-Danlos, as well as their common

complaints of widespread muscle and joint pain. Indeed, all 10

patients in this series complained of varying degrees of pelvic,

joint, and limb pain in the absence of articular swelling or

erythema. Nine had a history ofrecurrent joint dislocations,

requiring surgery in three cases, Dr. Geraghty noted.

All patients had abnormal results on orthostatic testing. Based upon

the results of an upright tilt-table test or a 10-minute standing

test, eightpatients had postural tachycardia syndrome, six had

neurally mediated hypotension, and four had both.

Several prior studies in patients with chronic fatigue syndrome have

shown application of military antishock trousers results in

symptomatic improvement, with prevention of orthostatic tachycardia

and hypotension. It's logical that symptoms of chronic fatigue and

orthostatic intolerance in patients with Ehlers-Danlos syndrome

might respond to vasoconstrictors that reduce gravitational venous

pooling, but this hypothesis awaits testing in randomized,controlled

trials.

Before using these agents in patients with Ehlers-Danlos syndrome,

however, the presence of an enlarged aortic root should be ruled

out. It's not a common abnormality -- it was present in 1 of 10

patients in this series -- but it predisposes to a feared

complication of the connective tissue disorder: dissecting aortic

aneurysm, he said.

[Guest guest]

I must have missed a message or two here. I did not see the above

mentioned article. Could you forward it to me.

---------------------------------

Chronic Fatigued Often Paired With Ehlers-Danlos Syndrome

Bruce Jancin, Denver Bureau

[Pediatric News 33(3):40, 1999. © 1999 International Medical News

Group.]

Denver -- Chronic fatigue syndrome appears to be common among

patients with Ehlers-Danlos syndrome, a connective tissue disorder

characterized by joint hypermobility, hyperelastic skin, and

connective tissue fragility.

Orthostatic intolerance is seen in both conditions, presumably

because connective tissue abnormalities predispose to excessive

venous pooling during upright posture. This explanation makes the

observed association biologically plausible, Dr. T. Geraghty

said at the annual meeting of the American Society of Human Genetics.

According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. Other

manifestations of the disorder may include acrocyanosis when limbs

are in a dependent position, wide papyraceous scarring over bony

prominences, ocular lesions, easy bruisability, and other vascular

abnormalities.

It's too early to say how often the two conditions coexist, however,

said Dr. Geraghty of s Hopkins University, Baltimore.

Dual-diagnosis patients may obtain symptomatic improvement using

medications that address orthostatic intolerance by reducing venous

pooling. Moreover, establishing the diagnosis of Ehlers-Danlos

syndrome has added benefits, including a heightened awareness of

potentially serious complications, improved detection of affected

relatives, and avoidance of unnecessary diagnostic and surgical

procedures.

Dr. Geraghty reported on 10 patients averaging 16 years of age who

were evaluated both in the Hopkins chronic fatigue syndrome clinic

and the genetics clinic. All met prevailing diagnostic criteria for

both disorders. Diagnosis of chronic fatigue syndrome preceded that

of Ehlers-Danlos by a median of 42 months in 9 of 10 patients.

The medical literature has historically underemphasized the easy

fatiguability of patients with Ehlers-Danlos, as well as their common

complaints of widespread muscle and joint pain. Indeed, all 10

patients in this series complained of varying degrees of pelvic,

joint, and limb pain in the absence of articular swelling or

erythema. Nine had a history ofrecurrent joint dislocations,

requiring surgery in three cases, Dr. Geraghty noted.

All patients had abnormal results on orthostatic testing. Based upon

the results of an upright tilt-table test or a 10-minute standing

test, eightpatients had postural tachycardia syndrome, six had

neurally mediated hypotension, and four had both.

Several prior studies in patients with chronic fatigue syndrome have

shown application of military antishock trousers results in

symptomatic improvement, with prevention of orthostatic tachycardia

and hypotension. It's logical that symptoms of chronic fatigue and

orthostatic intolerance in patients with Ehlers-Danlos syndrome

might respond to vasoconstrictors that reduce gravitational venous

pooling, but this hypothesis awaits testing in randomized,controlled

trials.

Before using these agents in patients with Ehlers-Danlos syndrome,

however, the presence of an enlarged aortic root should be ruled

out. It's not a common abnormality -- it was present in 1 of 10

patients in this series -- but it predisposes to a feared

complication of the connective tissue disorder: dissecting aortic

aneurysm, he said.

[Guest guest]

I must have missed a message or two here. I did not see the above

mentioned article. Could you forward it to me.

---------------------------------

Chronic Fatigued Often Paired With Ehlers-Danlos Syndrome

Bruce Jancin, Denver Bureau

[Pediatric News 33(3):40, 1999. © 1999 International Medical News

Group.]

Denver -- Chronic fatigue syndrome appears to be common among

patients with Ehlers-Danlos syndrome, a connective tissue disorder

characterized by joint hypermobility, hyperelastic skin, and

connective tissue fragility.

Orthostatic intolerance is seen in both conditions, presumably

because connective tissue abnormalities predispose to excessive

venous pooling during upright posture. This explanation makes the

observed association biologically plausible, Dr. T. Geraghty

said at the annual meeting of the American Society of Human Genetics.

According to other investigators, as many as one in nine people may

have a mild variant of the connective tissue disorder. Other

manifestations of the disorder may include acrocyanosis when limbs

are in a dependent position, wide papyraceous scarring over bony

prominences, ocular lesions, easy bruisability, and other vascular

abnormalities.

It's too early to say how often the two conditions coexist, however,

said Dr. Geraghty of s Hopkins University, Baltimore.

Dual-diagnosis patients may obtain symptomatic improvement using

medications that address orthostatic intolerance by reducing venous

pooling. Moreover, establishing the diagnosis of Ehlers-Danlos

syndrome has added benefits, including a heightened awareness of

potentially serious complications, improved detection of affected

relatives, and avoidance of unnecessary diagnostic and surgical

procedures.

Dr. Geraghty reported on 10 patients averaging 16 years of age who

were evaluated both in the Hopkins chronic fatigue syndrome clinic

and the genetics clinic. All met prevailing diagnostic criteria for

both disorders. Diagnosis of chronic fatigue syndrome preceded that

of Ehlers-Danlos by a median of 42 months in 9 of 10 patients.

The medical literature has historically underemphasized the easy

fatiguability of patients with Ehlers-Danlos, as well as their common

complaints of widespread muscle and joint pain. Indeed, all 10

patients in this series complained of varying degrees of pelvic,

joint, and limb pain in the absence of articular swelling or

erythema. Nine had a history ofrecurrent joint dislocations,

requiring surgery in three cases, Dr. Geraghty noted.

All patients had abnormal results on orthostatic testing. Based upon

the results of an upright tilt-table test or a 10-minute standing

test, eightpatients had postural tachycardia syndrome, six had

neurally mediated hypotension, and four had both.

Several prior studies in patients with chronic fatigue syndrome have

shown application of military antishock trousers results in

symptomatic improvement, with prevention of orthostatic tachycardia

and hypotension. It's logical that symptoms of chronic fatigue and

orthostatic intolerance in patients with Ehlers-Danlos syndrome

might respond to vasoconstrictors that reduce gravitational venous

pooling, but this hypothesis awaits testing in randomized,controlled

trials.

Before using these agents in patients with Ehlers-Danlos syndrome,

however, the presence of an enlarged aortic root should be ruled

out. It's not a common abnormality -- it was present in 1 of 10

patients in this series -- but it predisposes to a feared

complication of the connective tissue disorder: dissecting aortic

aneurysm, he said.