Dosing equivalents: 48 vs 8 hour TD DMPS

[Guest guest]

I just saw some posts (126178) on dosing equivalents and wanted to

review what has been recommended by Dr Buttar and give my take on a

dose equivalents.

Some of my opinion is based on these observations; The most common

comment from the 100 or so people who are reporting their experiences

with TD DMPS on the 48 hour regimen on other boards, is the dramatic

increase requirements of mineral supplements. Tangiable symptoms and

signs that appear and resolve with increased mineral supplementation

but no other changes. To me this suggests that metals are getting

depleted rapidly and out of whack from what would be expected from a

mg to mg dosing response compared to other routes for DMPS. I have no

reasonable explaination of why (maybe this formula somehow supplies a

substrate that amplifies mineral excretion?).

The recommended dose of the TD-DMPS is 1.5 mg per kg of body weight

and one drop is approximatley 1.5 mg (one drop per kg). So a 66 ibs

kid (30 kg)would get 45 mg every 48 hours or 30 drops. Why this dose?

I don't know, but Dr Buttar states that clinically this dose gave him

the best clinic reduction in symptoms in combination with the most

metal excretion.

So an equivalent dose number would be 7 doses over 48 hours given

every 8 hours. The dose would need to be .2mg per kg (1.5/7) So a 66

IBS or 30 kg kid would need .2 x 30 = 6mg or 4 drops every 8 hours.

The recommended max dose is 60 drops but that only means something if

the person weights more than 60 kg or 132 IBS, any kid under 60 kg

should be dosed by the .2 mg/kg every 8 hours, not by just dividing

the max dose by 48 hours.

One other note, Playing devils advocate on the every 8 hour regimen.

There are 2 considerations; the 1/2 life of DMPS and the observation

I made above about the mineral supplements. The hard part of 8 hours

regimen will be getting the mineral supplementation down pat and

understanding if side effects do come is it redistribution, a direct

drug effect or mineral depletion, to name just a few possibilities. I

don't know the right answer but from solely an experience point of

view, more people have tried the 48 hour regimen despite the lack

of " this makes sense kinetically " so there are more reports of what

to expect, on the other hand as more people do the every 8 hour

regimen we will learn a lot about it.

This is my take on the dosing dose, the interval used is up to the

individuals reading and experience

[Guest guest]

> The recommended dose of the TD-DMPS is 1.5 mg per kg of body weight

> and one drop is approximatley 1.5 mg (one drop per kg). So a 66 ibs

> kid (30 kg)would get 45 mg every 48 hours or 30 drops. Why this

dose?

> I don't know, but Dr Buttar states that clinically this dose gave

him

> the best clinic reduction in symptoms in combination with the most

> metal excretion.

My son is 51 pounds and is prescribed 33 drops. So something is wrong

either with my dosage or with the formula. Just FWIW...

[Guest guest]

Hi Rose, the 1.5 mg per drop and the 1.5mg per kg was a verbal from

Dr Buttar directly, but this was in june and I may have transcribed

it wrong. For your son the 33 drops is 49.5 mg of the DMPS, so it

appears that you are using one mg per pound or slightly more than 2.2

mg per kg. Lets call AMT 866-828-8203 and resolve this, I just called

but could not get thru.

>

> > The recommended dose of the TD-DMPS is 1.5 mg per kg of body

weight

> > and one drop is approximatley 1.5 mg (one drop per kg). So a 66

ibs

> > kid (30 kg)would get 45 mg every 48 hours or 30 drops. Why this

> dose?

> > I don't know, but Dr Buttar states that clinically this dose gave

> him

> > the best clinic reduction in symptoms in combination with the

most

> > metal excretion.

>

> My son is 51 pounds and is prescribed 33 drops. So something is

wrong

> either with my dosage or with the formula. Just FWIW...

[Guest guest]

This is what I was given from our practitioner based on my son's weight of

28 pounds.

~

Quote:

3.5 mg per dose every 8 hours for one week on, then one week off, and

repeat. His dose using Buttar's protocol would be 19.5 mg every 48 hours

[Guest guest]

Hi all:

My memory is faulty so I dig out the paper that came with the TD

DMPS titled " Buttar Autism Treatment Protocol. " In the first page it

states, under the " First 12 Months of Treatment " section:

" Start TD DMPS at 1.5mg/kg, not to exceed 60 drops, every other day

after testing is completed. "

" Example 1: 44lb child = 20 kg- Normal dose =30 drops every other

day. "

Raquel

[Guest guest]

Raquel, does it say on that paper what one drop equals? From the

example you gave one drop would have to be 1 mg...so a 20 kg kid at

1.5 mg per kg would need 30 mg per dose and they gave the dose at 30

drops sothat would have to be 1 mg per drop. This is different than

what I understood but again it was a verbal explanation to me.

>

> Hi all:

>

> My memory is faulty so I dig out the paper that came with the TD

> DMPS titled " Buttar Autism Treatment Protocol. " In the first page

it

> states, under the " First 12 Months of Treatment " section:

>

>

> " Start TD DMPS at 1.5mg/kg, not to exceed 60 drops, every other day

> after testing is completed. "

>

> " Example 1: 44lb child = 20 kg- Normal dose =30 drops every other

> day. "

>

> Raquel

[Guest guest]

OK, a clarification, from Dr. Buttar's office: they were going on 49

lbs at time of calculation, adn that is 33 drops. That weight is what

he was at the time, not 51 that I thought he was at the time

(actually, he is gaining weight rapidly, as Dr. Buttar says alot of

kids do, and more muscle mass it seems, so we'll have to re-weigh

today again and recalculate). Still, even at 51 pounds, it would be

34-35 drops for him. Sorry about this further confusion, I had simply

transposed the weight I had for him a month after starting to the

initial appt. where they gave me the calculation. Rose

> >

> > > The recommended dose of the TD-DMPS is 1.5 mg per kg of body

> weight

> > > and one drop is approximatley 1.5 mg (one drop per kg). So a 66

> ibs

> > > kid (30 kg)would get 45 mg every 48 hours or 30 drops. Why this

> > dose?

> > > I don't know, but Dr Buttar states that clinically this dose

gave

> > him

> > > the best clinic reduction in symptoms in combination with the

> most

> > > metal excretion.

> >

> > My son is 51 pounds and is prescribed 33 drops. So something is

> wrong

> > either with my dosage or with the formula. Just FWIW...

[Guest guest]

It says that a drop is a miligram indirectly: " Start TD DMPS at 1.5

mg/kg " , and it says in the example that " 44 lbs child= 20 kg- Normal

dose = 30 drops every other day. "

What I see with this info is that 1 drop is 1 miligram, so 1.5 drops

times 20 kg is 30 drops.

> >

> > Hi all:

> >

> > My memory is faulty so I dig out the paper that came with the TD

> > DMPS titled " Buttar Autism Treatment Protocol. " In the first

page

> it

> > states, under the " First 12 Months of Treatment " section:

> >

> >

> > " Start TD DMPS at 1.5mg/kg, not to exceed 60 drops, every other

day

> > after testing is completed. "

> >

> > " Example 1: 44lb child = 20 kg- Normal dose =30 drops every

other

> > day. "

> >

> > Raquel

[Guest guest]

Mine arrived today. We are 3 drops every 8 hours for a 28lb child

(I think he's more like 30 now, that weight was 2 months ago, and prior to

that going GFCF he gained 5 lbs in 6 months)

[Guest guest]

Great! Do let us know how it goes.

Raquel

> Mine arrived today. We are 3 drops every 8 hours for a 28lb child

>

> (I think he's more like 30 now, that weight was 2 months ago, and

prior to

> that going GFCF he gained 5 lbs in 6 months)

>

>