Aspartame Toxicity 1.8.01: Trocho 6.26.98

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Aspartame Toxicity 1.8.01: Trocho 6.26.98

Rich Murray, MA Room For All

1943 Otowi Road, Santa Fe, New Mexico 87505

rmforall@...

M.I.T. (physics and history, BA, 1964), Boston U. Graduate School

(psychology, MA, 1967): As a concerned layman, I want to clarify the

aspartame toxicity debate.

Aspartame (NutraSweet, Equal, Canderel, Benevia) is reported by

scientific studies and case histories to be toxic: headaches; many

body and joint pains (or burning, tingling, tremors, twitching,

spasms, cramps, or numbness); " mind fog " , " feel unreal " , poor memory,

confusion, anxiety, irritability, depression, mania, insomnia,

dizziness, slurred speech, ringing in ears, sexual problems, nausea,

seizures, poor vision, hearing, or taste; fever, fatigue; red face,

itching, rashes, burning eyes or throat, dry mouth or eyes, mouth

sores; hair loss; obesity, bloating, edema, poor or excessive hunger

or thirst, anorexia; coldness; diarrhea or constipation; breathing

problems; racing heart, high blood pressure, erratic blood sugar

levels; sweating; birth defects; brain cancers; addiction.

Almost all are typical of chronic methanol-formaldehyde toxicity.

Aspartame Victims Support Group [>250] and also Spanish translations

and Spanish egroup http://www.presidiotex.com/aspartame/

" The Dangers of Aspartame " discussion forum: many long reports by

Rich Murray: http://www.bevnet.com/bevboard/

Excellent 5-page review by H.J. in " Townsend Letter " ,

Jan 2000, " Aspartame (NutraSweet) Addiction "

http://www.dorway.com/tldaddic.html

H.J. , M.D. hroberts@... sunpress@...

Sunshine Sentinel Press 6708 Pamela Lane West Palm Beach, FL 33405

fax

What many informed doctors are saying/have said about aspartame:

http://www.dorway.com/doctors.txt

Dr. Woodrow C. Monte, " Aspartame: Methanol, and the Public Health, "

Journal of Applied Nutrition, Volume 36, No. 1, pages 42-54, 1984.

(62 references) Professsor of Food Science

Director of the Food Science and Nutrition Laboratory

Arizona State University, Tempe, Arizona 85287

6411 South River Drive #61 Tempe, Arizona 85283-3337

woody.monte@...

The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is

112 mg, 10% of the aspartame. The EPA limit for water is 7.8 mg daily

for methanol (wood alcohol), a deadly cumulative poison. Many users

drink 1-2 L daily. The reported symptoms are entirely consistent

with chronic methanol toxicity. (Fresh orange juice has 34 mg/L, but,

like all juices, has 16 times more ethanol, which strongly protects

against methanol.) www.dorway.com/wmonte.txt

A radioactive tracer study proves that the methanol from a low dose of

of aspartame binds formaldehyde, a deadly cumulative poison, into

tissues: Trocho C et al, June 26 1998, Life Sci, 63(5), 337-349.

www.presidiotex.com/barcelona/index.html

Lennart Hardell, M.D., PhD, in 1999 reported in Sweden that both

cell phone use and heavy aspartame use correlate with increased

brain cancers http://www.medscape.com/MedGenMed/braintumors

lennart.hardell@... +46 19 602 15 46

Users who quit often experience much immediate healing, but some

symptoms may last for weeks. Heavy users may suffer weeks of painful

withdrawal symptoms. Also avoid all forms of MSG (glutamate),

legally mislabeled as " hydrolyzed vegetable protein " or even

" natural flavoring " . Actually, all artificial sweeteners lack proof of

safety. It's fun to mix club soda with juices.

A long-used herbal sweetener, stevia, is entirely safe and

widely available. A corrupt FDA has refused to attest its safety:

www.holisticmed.com/sweet/stv-alert.txt

http://www.dorway.com/stevia.html stevia, splenda, others

Read all labels!-- aspartame is in almost all diet sodas, many drink

mixes, instant breakfasts, cereals, cake mixes, cookies, yogurts,

puddings, jellos, chewing gums, breath mints, candies, toothpastes,

laxatives, even vitamins and medicines. Absorption through the skin in

the mouth may be especially strong, close to the brain.

In the USA alone, about 200 million use this ubiquitous product of a

billion-dollar industry, first approved by a corrupt FDA in 1974 and

1981. In 1985, Monsanto purchased G.D. Searle, and made Searle

Pharmaceuticals and The NutraSweet Company separate subsidiaries.

In 2000 Monsanto sold off all its aspartame units.

If 1% of users have a problem with aspartame, that is two million in

the USA alone. Thousands of people complained to the FDA since 1981,

and in recent years on the Internet.

Ralph G. Walton, MD, Prof. of Clinical Psychology, Northeastern Ohio

Universities, College of Medicine, Dept. of Psychiatry, Youngstown,

OH 44501, Chairman, The Center for Behavioral Medicine,

Northside Medical Center, 500 Gypsy Lane, P.O. Box 240 Youngstown,

OH 44501 rwalton193@...

" Seizure and mania after high intake of aspartame, " 1986,

Psychosomatics, 27: 218-20:

An age 54 woman with 20 years of depression had been stable for 11

years with medication. She had a grand mal seizure, followed by

mania, insomnia, flight of ideas, and irritability. A brief

hospitalization and CT scan found no apparent cause. After three

weeks, this led to psychiatric hospitalization. Two days later,

it was found that during the several weeks before the seizure and

onset of mania, she had started using aspartame in place of sugar

in her iced tea, a gallon daily. Four days later, the mania subsided,

and 13 months later she continued to function well, and enjoying her

large amounts of iced tea, with sugar, not aspartame.

Three careful double-blind experimental studies prove aspartame

causes headaches: Koehler SM et al, 1988, Headache, 28(1), 10-14.

Shirley Koehler, PhD skoehler@...

Walton RG et al, 1993, Biological Psychiatry, 34(1), 13-17.

Prof. Ralph G. Walton rwalton193@...

Van Den Eeden SK et al, 1994, Neurology, 44, 1787-93.

K. Van Den Eeden, PhD skv@...

http://www.truthinlabeling.org/ Truth in Labeling Campaign [MSG]

Adrienne s, PhD P.O. Box 2532 Darien, Illinois 60561

adandjack@... " The Toxicity/Safety of Processed

Free Glutamic Acid (MSG): A Study in Suppression of Information "

Accountability in Research (1999) Vol 6, pp. 259-310

Health Press hlthprs@...

http://www.healthpress.com/in-bad-taste.html

R. Schwartz, M.D. drgschwartz@...

" In Bad Taste: The MSG Symptom Complex "

http://www.healingresearch.org/

Many long, referenced posts by Rich Murray are in the archive at

http://www.eGroups.com/community/aspartameNM/

http://www.dorway.com/blayenn.html dodd@...

L. Blaylock, M.D. russell@...

" Excitotoxins, Neurodegeneration and Neurodevelopment "

The Medical Sentinel Journal Fall, 1999 , (95 references)

UPI reporter Gordon: 96K 3-part expose Oct 1987:

http://www.dorway.com/upipart1.txt

Cover story in The Northern California Bohemian

[formerly Sonoma County Independent] by Bill Strubbe

September 28-October 4, 2000: Sweet 'n' Deadly?

Is aspartame killing dieters sweetly with its siren song?

http://www.metroactive.com/sonoma/aspartame-0039.html

editor@...

Aspartame Toxicity Information Center Mark D. Gold

www.HolisticMed.com/aspartame

" Scientific Abuse in Aspartame Research "

http://www.holisticmed.com/aspartame/abuse/methanol.html

mgold@... 12 East Side Drive #2-18 Concord, NH 03301

Mission-Possible-USA Betty i www.dorway.com

Bettym19@... http://www.dorway.com/asprlink.html many links

http://www.dorway.com/nslawsuit.txt Jeff , Attorney

Aspartame Consumer Safety Network

http://web2.airmail.net/marystod/index.html marystod@...

Nash Stoddard, " The Deadly Deception "

http://web2.airmail.net/marystod/espanol.htm

Geoff.Brewer@... United Kingdom Mission Possible International

63 Downlands Road DEVIZES SN10 5EF Tel: 01380 728059

http://www.connectotel.com/missionpossible/

The great health advantages of a no-fat vegetarian diet are well

described by Dr. A. McDougall at http:www.drmcdougall.com ,

which has copious scientific references and Net links, and at

http://www.vegsource.com

You may search among 11 million medical citations on PubMed for any

topic or author, and for many studies get an abstract summary:

http://www.ncbi.nlm.nih.gov/PubMed/

Here is research in 1998 at a very low level of aspartame ingestion,

10 mg/kg, for rats, which have a much greater tolerance for aspartame

than humans. The same level for humans would be about 1 or 2 mg/kg.

Many headache studies in humans used doses of about 30 mg/kg daily.

A daily dose of 2100mg aspartame, about 4 L diet soda, used in many

experimental tests on humans, supplies 210mg methanol into the body.

Many cases report a typical serious symptom syndrome at this level.

This report shows that aspartame causes binding of methanol's product,

formaldehyde, a potent, cumulative toxin, into tissues.

Life Sci June 26 1998; 63(5): 337-49 From PubMed

Formaldehyde derived from dietary aspartame binds to tissue

components in vivo. [ " Trok-ho " ]

Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X,

Fernandez- JA, Alemany M, Departament de Bioquimica i

Biologia Molecular, Facultat de Biologia, Universitat de Barcelona,

Spain. http://www.presidiotex.com/barcelona/index.html

Sra. Carme Trocho, Sra. rio Pardo, Dra. Immaculada Rafecas,

Sr. Jordi Virgili, X. Remesar, Dr. Fernandez-,

Dr. Alemany Fac. Biologia

Tel.: (93)4021521, Fax: (93)4021559

alemany@... bioq@...

rafecas@... remesar@...

Sra. Carme Trocho Tel.: (93)4021544, Fax: (93)4021559

Abstract:

Adult male rats were given an oral dose of 10 mg/kg aspartame,

14C-labelled in the methanol carbon. At timed intervals of up to 6

hours, the radioactivity in plasma and several organs was

investigated.

Most of the radioactivity found (>98% in plasma, >75% in liver) was

bound to protein. Label present in liver, plasma and kidney was in the

range of 1-2% of total radioactivity administered per g or mL,

changing little with time. Other organs (brown and white adipose

tissues, muscle, brain, cornea and retina) contained levels of label

in the range of 1/12th to 1/10th of that of liver. In all, the rat

retained, 6 hours after administration, about 5% of the label, half of

it in the liver.

The specific radioactivity of tissue protein, RNA and DNA was

quite uniform. The protein label was concentrated in amino acids,

different from methionine, and largely coincident with the result of

protein exposure to labelled formaldehyde. DNA radioactivity was

essentially in a single different adduct base, different from the

normal bases present in DNA.

The nature of the tissue label accumulated was, thus,

a direct consequence of formaldehyde binding

to tissue structures. The administration of labelled aspartame to a

group of cirrhotic rats resulted in comparable label retention by

tissue components, which suggests that liver function(or its defect)

has little effect on formaldehyde formation from aspartame and binding

to biological components. The chronic treatment of a series of rats

with 200 mg/kg of non-labelled aspartame during 10 days results in

the accumulation of even more label when given the radioactive bolus,

suggesting that the amount of formaldehyde adducts coming from

aspartame in tissue proteins and nucleic acids may be cumulative.

It is concluded that aspartame consumption may constitute a hazard

because of its contribution to the formation of formaldehyde adducts.

PMID: 9714421, UI: 98378223

Karikas GA, Schulpis KH, Reclos GJ, Kokotos G.

Dept. of Chemistry, University of Athens, Greece www.chem.uoa.gr

gkokotos@...

Measurement of molecular interaction of aspartame and

its metabolites with DNA. Clin Biochem. 1998 Jul;31(5):405-7.

Mark D. Gold has an excellent, detailed analysis, " Scientific Abuse in

Methanol / Formaldehyde Research Related to Aspartame " at:

http://www.holisticmed.com/aspartame/abuse/methanol.html#discussion

In short, biochemical evidence exists to motivate us to seriously and

respectfully consider anecdotal evidence of aspartame toxicity.

Mark D. Gold gives another detailed review, " Scientific Abuse in

Seizure Research Related to Aspartame " , at:

http://www.holisticmed.com/aspartame/abuse/seizures.html .

" If the seizures from aspartame are caused by the combination of

methanol/formaldehyde and the excitotoxic amino acid from aspartame,

as I believe may be the case, it is important to note that methanol is

10 times more acutely toxic in humans than in rodents (Roe 1982), and

it takes five times more excitotoxins given to rodents to simulate

human ingestion (Olney 1988, Stegink 1979, page 90). "

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