Guest guest Posted January 3, 2003 Report Share Posted January 3, 2003 I can respond to the muscle weight vs fat weight and adrenarche. When Dr H saw that Janelle had ballooned (over 95th% for weight for height - it happened very quickly so watch for it) having both adrenarche and now obese she wanted her building her muscles and put her on a diet. Janelle is now 50th % weight for height and we are working on the muscle building. I have to say (this has not been tested) but, as of late she doesn't seem to have so many signs of adrenarche as she did before. Let's hope. So after my long wind Dr H does believe in getting the muscle mass up more than getting them fat from my personal experience. -- Jovanovich ****Please note - our NEW e-mail address laura@... " mj_mcdonald2000@...> Reply-To: RSS-Support Date: Mon, 30 Dec 2002 03:25:00 -0000 To: RSS-Support Subject: Re: Dr. H Reply re Premature Adrenarche Resent-From: laura@... Resent-To: bugwilder@... Resent-Date: Sun, 29 Dec 2002 21:27:22 -0600 Hi, I'd like to comment and also have a few questions on Dr H's responses regarding adrenarche. If any of you remember, I posted a link to a British Medical Journal article that shows that low birth weight babies (under 5.6 lbs) had a 40 percent chance of becoming insulin resistant or diabetic in adulthood. It appears from what Dr H is saying, our kids generally fall into this 40 percent area. According to the article, as birth weight increases, there becomes less of a chance encountering these diseases later in life. Below is a list showing where percentages lie as related to birth weight. 40 percent (Equal to or less than 5.5 lbs) 34 percent (5.6 to 6.5 lbs) 31 percent (6.6 to 7.5 lbs) 22 percent (7.6 to 8.5 lbs) 13 percent (8.6 to 9.5 lbs) 14 percent (Greater than 9.5 lbs) The fact that , who is insulin resistant, was born a tiny little pea at 4.3 lbs lends credence to this study's findings. Along the same vein, could someone please let me know if whether I'm correctly interpreting what Dr H had to say about adrenarche. She seems to indicate that the more fat a child has, the sooner adrenarche will start? If this is true, shouldn't we be working to increase muscle weight rather than fat weight in order to lower insulin resistance? In a recent meeting with my daughter's doctor, he told me the more that fat cells increase relative to the muscle cells there is a reduction in insulin function, which can lead to greater insulin resistance. As best I can interpret what my doctor is doing, is that he is trying to minimize the rise in blood insulin levels. This leads me to believe that he agrees with Dr H that when insulin rises, then adrenarche is soon to follow. I would like to know what everyone else thinks about ways to gain muscle mass rapidly besides the GH that is already on. I want to be primed on this subject so that when we meet with the doctor next week I can discuss all options. Thanks for any advice/info you can provide. > Hello Listserve - > > I received a reply back from Dr. Madeleine Harbison in response to the email I > sent her where I consolidated Joe Blau's questions on premature adrenarche > with others that came up on the listserve. Here is her reply to each of the > questions. Salem, MAGIC RSS Division Consultant > *************** > > a) What exactly is the difference between adrenarche and puberty? > > Dr. H Response: Adrenarche is when the adrenal gland switched from making > glucocortcoids and mineralocorticoids to glucocortcoids, mineralocorticoids > and androgens [male hormones]. > > Puberty is when the brain switches from make LHRH in a linear pattern to a > pulsitile pattern. This changes the response of the pituitary from making > more FSH than LH to more LH than FSH. This starts the gonads to making sex > hormones. > > Does premature andrenarche imply that you will likely have premature > puberty? > > Dr. H Response: Yes, it sometimes does. > > c) How long after andrenarche does puberty typically begin? > > Dr. H Response: We do not know what starts adrenarche and we do not know why > adrenarche initiates puberty in some children and not in others. It ssems to > do so in SGA children for sure. It is hard to know when puberty will follow > after adrenarche starts but the more fat the child has the more likely it is > to start because androgens are converted to estrogens in fat. Estrogen is > really what controls puberty in both males and females. > > I believe that adrenarche starts when insulin rises. Insulin rises earlier in > SGA children than it does in normal children because they have insulin > resistance. > > d) What is your recommended treatment for premature adrenarche? > > Dr. H Response: There is no good way to treat premature adrenarche nor is > there a need to treat it because androgens do not cause the problem. Estrogen > causes the problem. If the bone age begins to advance rapidly, giving > Arimidex to prevent conversion of androgens to estrogen is the best > theoretical therapy. This is experimental therapy and not something that most > doctors will or should use. > > e) In addition to drugs to forestall puberty, how often should bone age and > hormone levels be checked and which hormones are the most important to watch? > > Dr. H Response: Meds that suppress puberty do not help with premature > adrenarche. When children are young, I do a BA yearly along with > testosterone, DHEA, androstenedione, E1 and E2. When they get older, show any > signs of sex hormone secretion, have an advancing BA or have a sudden growth > spurt, I do these tests every 6 mo. > > f) With regards to a specific family, what happens if you have a bone age that > is suddenly rapidly advancing, but NO other signs of puberty, > and the blood test hormone levels say that the child is not in puberty yet. > The child's bone age has always been 12-18 months delayed, and this last time > when she is just turning 8 years old, her bone age was only 6 months delayed. > Could it be that the bone age was misread? Or can you she be in " early > puberty " with no visible signs yet? > > Dr. H Response: This is likely the start of adrenarche. Young children are > very sensitive to very small amounts, BELOW MEASURABLE, amounts of estrogen. > Like the period of infancy, this is the period of RSS-SGA children's therapy > that requires experience. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2003 Report Share Posted January 3, 2003 No she is not on GH but yes it would help. I just do her PT and have her stand a lot...I figure anything will help. She did not move much before 16 months. She has been extremely hypotonic. -- Jovanovich ****Please note - our NEW e-mail address laura@... " mj_mcdonald2000@...> Reply-To: RSS-Support Date: Sat, 04 Jan 2003 02:50:21 -0000 To: RSS-Support Subject: Re: Dr. H Reply re Premature Adrenarche Resent-From: laura@... Resent-To: bugwilder@... Resent-Date: Fri, 3 Jan 2003 20:52:15 -0600 , Well I have to know how you are working on muscle building. Is Janelle on GH-- is. > > Hello Listserve - > > > > I received a reply back from Dr. Madeleine Harbison in response to > the email I > > sent her where I consolidated Joe Blau's questions on premature > adrenarche > > with others that came up on the listserve. Here is her reply to > each of the > > questions. Salem, MAGIC RSS Division Consultant > > *************** > > > > a) What exactly is the difference between adrenarche and puberty? > > > > Dr. H Response: Adrenarche is when the adrenal gland switched from > making > > glucocortcoids and mineralocorticoids to glucocortcoids, > mineralocorticoids > > and androgens [male hormones]. > > > > Puberty is when the brain switches from make LHRH in a linear > pattern to a > > pulsitile pattern. This changes the response of the pituitary from > making > > more FSH than LH to more LH than FSH. This starts the gonads to > making sex > > hormones. > > > > Does premature andrenarche imply that you will likely have > premature > > puberty? > > > > Dr. H Response: Yes, it sometimes does. > > > > c) How long after andrenarche does puberty typically begin? > > > > Dr. H Response: We do not know what starts adrenarche and we do > not know why > > adrenarche initiates puberty in some children and not in others. > It ssems to > > do so in SGA children for sure. It is hard to know when puberty > will follow > > after adrenarche starts but the more fat the child has the more > likely it is > > to start because androgens are converted to estrogens in fat. > Estrogen is > > really what controls puberty in both males and females. > > > > I believe that adrenarche starts when insulin rises. Insulin rises > earlier in > > SGA children than it does in normal children because they have > insulin > > resistance. > > > > d) What is your recommended treatment for premature adrenarche? > > > > Dr. H Response: There is no good way to treat premature adrenarche > nor is > > there a need to treat it because androgens do not cause the > problem. Estrogen > > causes the problem. If the bone age begins to advance rapidly, > giving > > Arimidex to prevent conversion of androgens to estrogen is the best > > theoretical therapy. This is experimental therapy and not > something that most > > doctors will or should use. > > > > e) In addition to drugs to forestall puberty, how often should bone > age and > > hormone levels be checked and which hormones are the most important > to watch? > > > > Dr. H Response: Meds that suppress puberty do not help with > premature > > adrenarche. When children are young, I do a BA yearly along with > > testosterone, DHEA, androstenedione, E1 and E2. When they get > older, show any > > signs of sex hormone secretion, have an advancing BA or have a > sudden growth > > spurt, I do these tests every 6 mo. > > > > f) With regards to a specific family, what happens if you have a > bone age that > > is suddenly rapidly advancing, but NO other signs of puberty, > > and the blood test hormone levels say that the child is not in > puberty yet. > > The child's bone age has always been 12-18 months delayed, and this > last time > > when she is just turning 8 years old, her bone age was only 6 > months delayed. > > Could it be that the bone age was misread? Or can you she be > in " early > > puberty " with no visible signs yet? > > > > Dr. H Response: This is likely the start of adrenarche. Young > children are > > very sensitive to very small amounts, BELOW MEASURABLE, amounts of > estrogen. > > Like the period of infancy, this is the period of RSS-SGA > children's therapy > > that requires experience. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2003 Report Share Posted January 3, 2003 Hi Ava:-) I am not sure if Dr H was speculating or not but she thought if she could get Janelle's weight down the adrenarche would slow down. From visual signs it looks as if it has. Dr H just put her on a diet of 85-95 Kcal per Kilogram. It just worked. Janelle its tube fed which makes this easy. I would ask your endo again. Janelle is not taking medication for the adrenarche. -- Jovanovich ****Please note - our NEW e-mail address laura@... " house2home@...> Reply-To: RSS-Support Date: Sat, 04 Jan 2003 05:54:37 -0000 To: RSS-Support Subject: Re: Dr. H Reply re Premature Adrenarche Resent-From: laura@... Resent-To: bugwilder@... Resent-Date: Fri, 3 Jan 2003 23:56:39 -0600 Hi , Thank you so much for your information. I am rather new to all of this and finding the listserv is the best support for me. My daughter ita, just turned 6 and she is 95% for weight vs. height. Jua was an SGA (small for gestiional age...saw the ??!!! and IUGR weighing only 2.0 lbs at 31 weeks (talk about a pea!!). We just took her to the endo yesterday. ita was between the 3rd and 5th% for the first 4 years then WAMMO!!...growth spurt betw jan. 21, 02 to sept. 13, 02-- 4 " , huge weight gain, and a bone age of 8yrs, 10 months and adrenarche. (Don't have to look for it.... it is here :-( We have been asked to consider LUPRON by February 3. You did not say if your child is on treatment.... so here is a question for all..... Is anyone currently using LUPRON and does it work for the SGA and IUGR child???????? Also, any tips on getting ita down to 50% weight for height would be great to hear. We exersise 3x per week but all that does is keep her from gaining. She is and has been at 60lbs but has bouncbbed up to 62.5, Jua went from 10% to just under 50% with the spurt. Also is the weight my fault? I have been surfing the net and this seems a big question in the medical community regarding what brings on adrenarcheb. I need to understand this. Yesterday the endo began speaking about the weight but drifted off to the adrenarche so I was not clear on what she was saying. Thanks, AvaMarie > > Hello Listserve - > > > > I received a reply back from Dr. Madeleine Harbison in response to > the email I > > sent her where I consolidated Joe Blau's questions on premature > adrenarche > > with others that came up on the listserve. Here is her reply to > each of the > > questions. Salem, MAGIC RSS Division Consultant > > *************** > > > > a) What exactly is the difference between adrenarche and puberty? > > > > Dr. H Response: Adrenarche is when the adrenal gland switched from > making > > glucocortcoids and mineralocorticoids to glucocortcoids, > mineralocorticoids > > and androgens [male hormones]. > > > > Puberty is when the brain switches from make LHRH in a linear > pattern to a > > pulsitile pattern. This changes the response of the pituitary from > making > > more FSH than LH to more LH than FSH. This starts the gonads to > making sex > > hormones. > > > > Does premature andrenarche imply that you will likely have > premature > > puberty? > > > > Dr. H Response: Yes, it sometimes does. > > > > c) How long after andrenarche does puberty typically begin? > > > > Dr. H Response: We do not know what starts adrenarche and we do > not know why > > adrenarche initiates puberty in some children and not in others. > It ssems to > > do so in SGA children for sure. It is hard to know when puberty > will follow > > after adrenarche starts but the more fat the child has the more > likely it is > > to start because androgens are converted to estrogens in fat. > Estrogen is > > really what controls puberty in both males and females. > > > > I believe that adrenarche starts when insulin rises. Insulin rises > earlier in > > SGA children than it does in normal children because they have > insulin > > resistance. > > > > d) What is your recommended treatment for premature adrenarche? > > > > Dr. H Response: There is no good way to treat premature adrenarche > nor is > > there a need to treat it because androgens do not cause the > problem. Estrogen > > causes the problem. If the bone age begins to advance rapidly, > giving > > Arimidex to prevent conversion of androgens to estrogen is the best > > theoretical therapy. This is experimental therapy and not > something that most > > doctors will or should use. > > > > e) In addition to drugs to forestall puberty, how often should bone > age and > > hormone levels be checked and which hormones are the most important > to watch? > > > > Dr. H Response: Meds that suppress puberty do not help with > premature > > adrenarche. When children are young, I do a BA yearly along with > > testosterone, DHEA, androstenedione, E1 and E2. When they get > older, show any > > signs of sex hormone secretion, have an advancing BA or have a > sudden growth > > spurt, I do these tests every 6 mo. > > > > f) With regards to a specific family, what happens if you have a > bone age that > > is suddenly rapidly advancing, but NO other signs of puberty, > > and the blood test hormone levels say that the child is not in > puberty yet. > > The child's bone age has always been 12-18 months delayed, and this > last time > > when she is just turning 8 years old, her bone age was only 6 > months delayed. > > Could it be that the bone age was misread? Or can you she be > in " early > > puberty " with no visible signs yet? > > > > Dr. H Response: This is likely the start of adrenarche. Young > children are > > very sensitive to very small amounts, BELOW MEASURABLE, amounts of > estrogen. > > Like the period of infancy, this is the period of RSS-SGA > children's therapy > > that requires experience. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2003 Report Share Posted January 4, 2003 I would talk to the endo and a dietician. For a non RSS child I would reduce the carbs ( do not eliminate them) increase the vegetables and supply lean meats and avoid fats in excess. They need some fat. -- Jovanovich ****Please note - our NEW e-mail address laura@... " mj_mcdonald2000@...> Reply-To: RSS-Support Date: Sat, 04 Jan 2003 19:27:02 -0000 To: RSS-Support Subject: Re: Dr. H Reply re Premature Adrenarche Resent-From: laura@... Resent-To: bugwilder@... Resent-Date: Sat, 4 Jan 2003 13:31:52 -0600 , I reread my message to you from yesterday and all I can say is that I've been really stressed this week, so I apologize for not making much sense in what I asked. I guess what I'd really like to find out is whether there are any foods or diets that you try to use to reduce fat and build muscle? Thanks. > > > Hello Listserve - > > > > > > I received a reply back from Dr. Madeleine Harbison in response to > > the email I > > > sent her where I consolidated Joe Blau's questions on premature > > adrenarche > > > with others that came up on the listserve. Here is her reply to > > each of the > > > questions. Salem, MAGIC RSS Division Consultant > > > *************** > > > > > > a) What exactly is the difference between adrenarche and puberty? > > > > > > Dr. H Response: Adrenarche is when the adrenal gland switched > from > > making > > > glucocortcoids and mineralocorticoids to glucocortcoids, > > mineralocorticoids > > > and androgens [male hormones]. > > > > > > Puberty is when the brain switches from make LHRH in a linear > > pattern to a > > > pulsitile pattern. This changes the response of the pituitary > from > > making > > > more FSH than LH to more LH than FSH. This starts the gonads to > > making sex > > > hormones. > > > > > > Does premature andrenarche imply that you will likely have > > premature > > > puberty? > > > > > > Dr. H Response: Yes, it sometimes does. > > > > > > c) How long after andrenarche does puberty typically begin? > > > > > > Dr. H Response: We do not know what starts adrenarche and we do > > not know why > > > adrenarche initiates puberty in some children and not in others. > > It ssems to > > > do so in SGA children for sure. It is hard to know when puberty > > will follow > > > after adrenarche starts but the more fat the child has the more > > likely it is > > > to start because androgens are converted to estrogens in fat. > > Estrogen is > > > really what controls puberty in both males and females. > > > > > > I believe that adrenarche starts when insulin rises. Insulin > rises > > earlier in > > > SGA children than it does in normal children because they have > > insulin > > > resistance. > > > > > > d) What is your recommended treatment for premature adrenarche? > > > > > > Dr. H Response: There is no good way to treat premature > adrenarche > > nor is > > > there a need to treat it because androgens do not cause the > > problem. Estrogen > > > causes the problem. If the bone age begins to advance rapidly, > > giving > > > Arimidex to prevent conversion of androgens to estrogen is the > best > > > theoretical therapy. This is experimental therapy and not > > something that most > > > doctors will or should use. > > > > > > e) In addition to drugs to forestall puberty, how often should > bone > > age and > > > hormone levels be checked and which hormones are the most > important > > to watch? > > > > > > Dr. H Response: Meds that suppress puberty do not help with > > premature > > > adrenarche. When children are young, I do a BA yearly along with > > > testosterone, DHEA, androstenedione, E1 and E2. When they get > > older, show any > > > signs of sex hormone secretion, have an advancing BA or have a > > sudden growth > > > spurt, I do these tests every 6 mo. > > > > > > f) With regards to a specific family, what happens if you have a > > bone age that > > > is suddenly rapidly advancing, but NO other signs of puberty, > > > and the blood test hormone levels say that the child is not in > > puberty yet. > > > The child's bone age has always been 12-18 months delayed, and > this > > last time > > > when she is just turning 8 years old, her bone age was only 6 > > months delayed. > > > Could it be that the bone age was misread? Or can you she be > > in " early > > > puberty " with no visible signs yet? > > > > > > Dr. H Response: This is likely the start of adrenarche. Young > > children are > > > very sensitive to very small amounts, BELOW MEASURABLE, amounts of > > estrogen. > > > Like the period of infancy, this is the period of RSS-SGA > > children's therapy > > > that requires experience. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2003 Report Share Posted January 4, 2003 I would talk to the endo and a dietician. For a non RSS child I would reduce the carbs ( do not eliminate them) increase the vegetables and supply lean meats and avoid fats in excess. They need some fat. -- Jovanovich ****Please note - our NEW e-mail address laura@... " mj_mcdonald2000@...> Reply-To: RSS-Support Date: Sat, 04 Jan 2003 19:27:02 -0000 To: RSS-Support Subject: Re: Dr. H Reply re Premature Adrenarche Resent-From: laura@... Resent-To: bugwilder@... Resent-Date: Sat, 4 Jan 2003 13:31:52 -0600 , I reread my message to you from yesterday and all I can say is that I've been really stressed this week, so I apologize for not making much sense in what I asked. I guess what I'd really like to find out is whether there are any foods or diets that you try to use to reduce fat and build muscle? Thanks. > > > Hello Listserve - > > > > > > I received a reply back from Dr. Madeleine Harbison in response to > > the email I > > > sent her where I consolidated Joe Blau's questions on premature > > adrenarche > > > with others that came up on the listserve. Here is her reply to > > each of the > > > questions. Salem, MAGIC RSS Division Consultant > > > *************** > > > > > > a) What exactly is the difference between adrenarche and puberty? > > > > > > Dr. H Response: Adrenarche is when the adrenal gland switched > from > > making > > > glucocortcoids and mineralocorticoids to glucocortcoids, > > mineralocorticoids > > > and androgens [male hormones]. > > > > > > Puberty is when the brain switches from make LHRH in a linear > > pattern to a > > > pulsitile pattern. This changes the response of the pituitary > from > > making > > > more FSH than LH to more LH than FSH. This starts the gonads to > > making sex > > > hormones. > > > > > > Does premature andrenarche imply that you will likely have > > premature > > > puberty? > > > > > > Dr. H Response: Yes, it sometimes does. > > > > > > c) How long after andrenarche does puberty typically begin? > > > > > > Dr. H Response: We do not know what starts adrenarche and we do > > not know why > > > adrenarche initiates puberty in some children and not in others. > > It ssems to > > > do so in SGA children for sure. It is hard to know when puberty > > will follow > > > after adrenarche starts but the more fat the child has the more > > likely it is > > > to start because androgens are converted to estrogens in fat. > > Estrogen is > > > really what controls puberty in both males and females. > > > > > > I believe that adrenarche starts when insulin rises. Insulin > rises > > earlier in > > > SGA children than it does in normal children because they have > > insulin > > > resistance. > > > > > > d) What is your recommended treatment for premature adrenarche? > > > > > > Dr. H Response: There is no good way to treat premature > adrenarche > > nor is > > > there a need to treat it because androgens do not cause the > > problem. Estrogen > > > causes the problem. If the bone age begins to advance rapidly, > > giving > > > Arimidex to prevent conversion of androgens to estrogen is the > best > > > theoretical therapy. This is experimental therapy and not > > something that most > > > doctors will or should use. > > > > > > e) In addition to drugs to forestall puberty, how often should > bone > > age and > > > hormone levels be checked and which hormones are the most > important > > to watch? > > > > > > Dr. H Response: Meds that suppress puberty do not help with > > premature > > > adrenarche. When children are young, I do a BA yearly along with > > > testosterone, DHEA, androstenedione, E1 and E2. When they get > > older, show any > > > signs of sex hormone secretion, have an advancing BA or have a > > sudden growth > > > spurt, I do these tests every 6 mo. > > > > > > f) With regards to a specific family, what happens if you have a > > bone age that > > > is suddenly rapidly advancing, but NO other signs of puberty, > > > and the blood test hormone levels say that the child is not in > > puberty yet. > > > The child's bone age has always been 12-18 months delayed, and > this > > last time > > > when she is just turning 8 years old, her bone age was only 6 > > months delayed. > > > Could it be that the bone age was misread? Or can you she be > > in " early > > > puberty " with no visible signs yet? > > > > > > Dr. H Response: This is likely the start of adrenarche. Young > > children are > > > very sensitive to very small amounts, BELOW MEASURABLE, amounts of > > estrogen. > > > Like the period of infancy, this is the period of RSS-SGA > > children's therapy > > > that requires experience. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2003 Report Share Posted January 4, 2003 Hi , My name is Pat and is my grandson. Wouldn't you do this the same way that you would with any child? I would feed good complex carbs, if you have any problems with hypo-g, and good sources of protein. My kids love veggies, and you could make a low fat cheese sauce to go over. Most kids will eat them that way. Fish and chicken are good sources of protein, and lower in fat. You'll need the protein to build muscle. As far as exercise goes, I would find something that your child like to do, and build from there. One of my 4 kids loved soccer and two were into ball. the fourth wasn't into anything sports wise, but loved going on walks with me, or bike rides, and we would have wonderful talks. Hope this helps! Pat (g-ma to Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2003 Report Share Posted January 4, 2003 Hi , My name is Pat and is my grandson. Wouldn't you do this the same way that you would with any child? I would feed good complex carbs, if you have any problems with hypo-g, and good sources of protein. My kids love veggies, and you could make a low fat cheese sauce to go over. Most kids will eat them that way. Fish and chicken are good sources of protein, and lower in fat. You'll need the protein to build muscle. As far as exercise goes, I would find something that your child like to do, and build from there. One of my 4 kids loved soccer and two were into ball. the fourth wasn't into anything sports wise, but loved going on walks with me, or bike rides, and we would have wonderful talks. Hope this helps! Pat (g-ma to Quote Link to comment Share on other sites More sharing options...
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