Re: Glimepride-Rob: was-dying

[Guest guest]

I remember a thread referring to this class of drugs and that they wear out the

Beta Cells quicker by forcing them to produce more insulin.

If I am IR then these drugs are counter-productive and are just wasting my Beta

cells, correct?

If I am not producing enough insulin then it would also be better to have a

basal insulin and a faster acting one for mealtimes. Is that true?

I think I understand what is said about this situation, but just need some

confirmation.

Thanks

Rob

Glimepride-Rob: was-dying

Rob,

Glimepride is the generic for Amaryl, an older " sulfonylurea-class " drug for

diabetes that works by forcing the pancreas to produce more insulin (needed

or not)

There are issues with that particular class of drug, but with your present

other problems, you don't need to concern yourself about that for now.

You are in my thoughts & I hope you can get some help (your shrink) soon

although that sounds like another whole issue in itself.

Take care of yourself. I look forward to your posts on this list.

, T2, etc.....

[Guest guest]

It is just a theory that these drugs wear out the Beta cells, but has

never been proven. High BG's wear out the Beta cells. If these drugs

help you achieve normal BG's, the Beta cells should be protected. For

years I took glynase, and then was switched to Prandin. My Beta cells

seem to be alive and well and capable of being prodded. Sue

On Tuesday, October 18, 2005, at 01:51 PM, Rob Fearnley wrote:

> I remember a thread referring to this class of drugs and that they

> wear out the Beta Cells quicker by forcing them to produce more

> insulin.

[Guest guest]

> It is just a theory that these drugs wear out the Beta cells, but has

> never been proven. High BG's wear out the Beta cells. If these drugs

I guess the answer isn't known. I asked the doctor to switch my

husband from glyburide to metformin and he agreed but he didn't agree

that glyrudie " wears out " the pancreas.

To me, a drug that attacks what we think the problem is is better than

a drug that just tries to overwhelm the problem. In this case by

prodding the pancreas to release even more insulin. For type 2

diabetics, the pancreas is probably already overworked. So if

possible, it makes sense to me to try to attack the problem from the

insulin resistance end or otherwise in the use of insulin and other

ways to reduce BG.

There is some evidence that injecting insulin allows the beta cells to

" rest " which helps them. It could be that that is just because of

better BG control, though.

I think there is no doubt that high BG destroys beta cells.

Judy

[Guest guest]

> It is just a theory that these drugs wear out the Beta cells, but has

> never been proven. High BG's wear out the Beta cells. If these drugs

I guess the answer isn't known. I asked the doctor to switch my

husband from glyburide to metformin and he agreed but he didn't agree

that glyrudie " wears out " the pancreas.

To me, a drug that attacks what we think the problem is is better than

a drug that just tries to overwhelm the problem. In this case by

prodding the pancreas to release even more insulin. For type 2

diabetics, the pancreas is probably already overworked. So if

possible, it makes sense to me to try to attack the problem from the

insulin resistance end or otherwise in the use of insulin and other

ways to reduce BG.

There is some evidence that injecting insulin allows the beta cells to

" rest " which helps them. It could be that that is just because of

better BG control, though.

I think there is no doubt that high BG destroys beta cells.

Judy

[Guest guest]

> It is just a theory that these drugs wear out the Beta cells, but has

> never been proven. High BG's wear out the Beta cells. If these drugs

I guess the answer isn't known. I asked the doctor to switch my

husband from glyburide to metformin and he agreed but he didn't agree

that glyrudie " wears out " the pancreas.

To me, a drug that attacks what we think the problem is is better than

a drug that just tries to overwhelm the problem. In this case by

prodding the pancreas to release even more insulin. For type 2

diabetics, the pancreas is probably already overworked. So if

possible, it makes sense to me to try to attack the problem from the

insulin resistance end or otherwise in the use of insulin and other

ways to reduce BG.

There is some evidence that injecting insulin allows the beta cells to

" rest " which helps them. It could be that that is just because of

better BG control, though.

I think there is no doubt that high BG destroys beta cells.

Judy

[Guest guest]

I take metformin as well as Prandin. I need both, and also limit my

carbs. Prandin is a newer drug than sulfs such as glyburide and

glynase, which I used to take. Prandin is much better, in my opinion,

because it works for a few hours and then stops. The sulfs keep working

continuously, long after the meal has digested and the need for it is

gone. Of course, Prandin is also more expensive. Sue

On Tuesday, October 18, 2005, at 05:45 PM, judith_nicholls wrote:

> I guess the answer isn't known. I asked the doctor to switch my

> husband from glyburide to metformin and he agreed but he didn't agree

> that glyrudie " wears out " the pancreas.

>

> To me, a drug that attacks what we think the problem is is better than

> a drug that just tries to overwhelm the problem. In this case by

> prodding the pancreas to release even more insulin.

[Guest guest]

I take metformin as well as Prandin. I need both, and also limit my

carbs. Prandin is a newer drug than sulfs such as glyburide and

glynase, which I used to take. Prandin is much better, in my opinion,

because it works for a few hours and then stops. The sulfs keep working

continuously, long after the meal has digested and the need for it is

gone. Of course, Prandin is also more expensive. Sue

On Tuesday, October 18, 2005, at 05:45 PM, judith_nicholls wrote:

> I guess the answer isn't known. I asked the doctor to switch my

> husband from glyburide to metformin and he agreed but he didn't agree

> that glyrudie " wears out " the pancreas.

>

> To me, a drug that attacks what we think the problem is is better than

> a drug that just tries to overwhelm the problem. In this case by

> prodding the pancreas to release even more insulin.

[Guest guest]

I take metformin as well as Prandin. I need both, and also limit my

carbs. Prandin is a newer drug than sulfs such as glyburide and

glynase, which I used to take. Prandin is much better, in my opinion,

because it works for a few hours and then stops. The sulfs keep working

continuously, long after the meal has digested and the need for it is

gone. Of course, Prandin is also more expensive. Sue

On Tuesday, October 18, 2005, at 05:45 PM, judith_nicholls wrote:

> I guess the answer isn't known. I asked the doctor to switch my

> husband from glyburide to metformin and he agreed but he didn't agree

> that glyrudie " wears out " the pancreas.

>

> To me, a drug that attacks what we think the problem is is better than

> a drug that just tries to overwhelm the problem. In this case by

> prodding the pancreas to release even more insulin.

[Guest guest]

OK, this has been bounced around a lot. The real thiing is that lowering bg by

using the pills

relieves most of what kills the Beta cells. The pills don't do nearly as much

harm as people say

IF bg is controlled reasonably well. The scare was raised because some people

take the pills,

don't control bg, and the Beta cells are killed off by the glucose, NOT the

pills.

Ted Quick

--- Rob Fearnley wrote:

>

>

> I remember a thread referring to this class of drugs and that they wear out

the Beta Cells

> quicker by forcing them to produce more insulin.

>

> If I am IR then these drugs are counter-productive and are just wasting my

Beta cells, correct?

>

> If I am not producing enough insulin then it would also be better to have a

basal insulin and a

> faster acting one for mealtimes. Is that true?

>

> I think I understand what is said about this situation, but just need some

confirmation.

>

> Thanks

>

> Rob

> Glimepride-Rob: was-dying

>

>

>

> Rob,

> Glimepride is the generic for Amaryl, an older " sulfonylurea-class " drug

for

> diabetes that works by forcing the pancreas to produce more insulin (needed

> or not)

> There are issues with that particular class of drug, but with your present

> other problems, you don't need to concern yourself about that for now.

>

> You are in my thoughts & I hope you can get some help (your shrink) soon

> although that sounds like another whole issue in itself.

> Take care of yourself. I look forward to your posts on this list.

> , T2, etc.....

>

>

>