[Fwd: [lowdosenaltrexone] Something you may want to consider]

May 23, 2005

From someone on the lowdosenaltrexone group for those of you using

LDN. I have no idea of this guy's background or training but it is

worth a read and possibly trying if you don't think LDN is doing

anything much for you.

Hi all you folks taking LDN for various reasons,

If it is working for you -- awesome. If it isn't you might consider

experimenting with the times you take it. The mechanism of action is

a temporary blockade of endorphin/opiod receptors at a specific time

(early morning hours, when endorphin production is supposed to occur,

causing the body to, in the words of Jay Leno, make more

(endorphins). Given genetic variation and induced changes which may

occur from lifestyle (maybe you are a night owl, work night shifts,

or God help you, rotating shifts, etc...) your own periods of (peak)

endorphin production may be shifted from these early hours of the

day. I have no idea what range of variation there could be from the

norm or if there even is such a thing, so the only way you could know

would be through experimentation with when you take the LDN. You may

try taking it one, two or more hours earlier, or stay up later to

take it. Hopefully whoever is prescribing LDN is knowledgible enough

to guide you in how to take it. Any of you, lucky enough to have

blood tests for endorphin levels, especially [met5]enkephalin levels

for cancer patients, will know if your getting the results of the LDN

(these tests are very expensive and probably aren't done for most

patients in normal med labs). If not, I'd advise you you speak with

your Doc. or even Dr. Bihari, since he knows most about LDN,.

Don't get discouraged with your results, LDN is about as close to

cutting edge tech. as you can get, w/o the benefit of a huge research

grant and a high tech. lab. Since it is as safe a drug as anything

out there it can't hurt to mix things up a bit.

Good Luck to all,

Hans

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