Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 > Dear Friends, > In 1999, they found a vacuole, which Dr. Hirano from Columbia said was > very " unusual. " I have read since that vacuoles are common in > inclusion-body myositis. My endo,who gave me a provisional dx of mito in > 1998, still thinks that I may have some form of myositis. But my > deafness fits the mito pattern much more closely. Vacuoles (holes) can be found in various muscle diseases. I have seen reports of vacuoles in lipid storage disorders, McArdles, and also associated with COX deficient fibers. This in addition to inclusion-body myositis, which you mentioned. In an abstract of a 2001 review of 113 muscle biopsies in patients with definite MITO or presumed MITO, vacuoles were not specifically mentioned, but the study did find increased glycogen deposition and lipid accumulation in multiple patients, and those excesses can accumulate in vacuoles. The full-length article (which I have not seen) may clarify whether the excess glycogen and lipid was associated with vacuoles in those mito cases. Hope the biopsy goes well and that you get some useful information. Barbara Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Barbara From my work with kids who are taking biology, all cells cantain vacuoles or empty spaces. I don't know how they might change in disease, but they are there to start with. laurie > > Reply-To: > Date: Thu, 07 Oct 2004 18:27:05 -0000 > To: > Subject: Re: vacuoles > > > >> Dear Friends, > >> In 1999, they found a vacuole, which Dr. Hirano from Columbia said > was >> very " unusual. " I have read since that vacuoles are common in >> inclusion-body myositis. My endo,who gave me a provisional dx of > mito in >> 1998, still thinks that I may have some form of myositis. But my >> deafness fits the mito pattern much more closely. > > Vacuoles (holes) can be found in various muscle diseases. I have > seen reports of vacuoles in lipid storage disorders, McArdles, and > also associated with COX deficient fibers. This in addition to > inclusion-body myositis, which you mentioned. In an abstract of a > 2001 review of 113 muscle biopsies in patients with definite MITO or > presumed MITO, vacuoles were not specifically mentioned, but the > study did find increased glycogen deposition and lipid accumulation > in multiple patients, and those excesses can accumulate in vacuoles. > The full-length article (which I have not seen) may clarify whether > the excess glycogen and lipid was associated with vacuoles in those > mito cases. > > Hope the biopsy goes well and that you get some useful information. > Barbara > > > > > > Medical advice, information, opinions, data and statements contained herein > are not necessarily those of the list moderators. The author of this e mail is > entirely responsible for its content. List members are reminded of their > responsibility to evaluate the content of the postings and consult with their > physicians regarding changes in their own treatment. > > Personal attacks are not permitted on the list and anyone who sends one is > automatically moderated or removed depending on the severity of the attack. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Tks, Laurie, for this clarification. I'm obviously not a biologist. I only know that vacuoles have been reported as abnormal pathology in muscle biopsies and associated with various muscle diseases. The adjective I've seen most often is " rimmed " but adjectives are not always used. I'm puzzled as to why any pathologist would report a vacuole as a significant finding if all cells contain them? Beats me. Barbara > >> Dear Friends, > > > >> In 1999, they found a vacuole, which Dr. Hirano from Columbia said > > was > >> very " unusual. " I have read since that vacuoles are common in > >> inclusion-body myositis. My endo,who gave me a provisional dx of > > mito in > >> 1998, still thinks that I may have some form of myositis. But my > >> deafness fits the mito pattern much more closely. > > > > Vacuoles (holes) can be found in various muscle diseases. I have > > seen reports of vacuoles in lipid storage disorders, McArdles, and > > also associated with COX deficient fibers. This in addition to > > inclusion-body myositis, which you mentioned. In an abstract of a > > 2001 review of 113 muscle biopsies in patients with definite MITO or > > presumed MITO, vacuoles were not specifically mentioned, but the > > study did find increased glycogen deposition and lipid accumulation > > in multiple patients, and those excesses can accumulate in vacuoles. > > The full-length article (which I have not seen) may clarify whether > > the excess glycogen and lipid was associated with vacuoles in those > > mito cases. > > > > Hope the biopsy goes well and that you get some useful information. > > Barbara > > > > > > > > > > > > Medical advice, information, opinions, data and statements contained herein > > are not necessarily those of the list moderators. The author of this e mail is > > entirely responsible for its content. List members are reminded of their > > responsibility to evaluate the content of the postings and consult with their > > physicians regarding changes in their own treatment. > > > > Personal attacks are not permitted on the list and anyone who sends one is > > automatically moderated or removed depending on the severity of the attack. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Barbara Beats me too! I've helped my students to make cell models and it always a challenge to create empty space. Balloons that are little and have just a little air in them has helped. I guess it is time to pull a biology book off my shelf and check it out. laurie > > Reply-To: > Date: Thu, 07 Oct 2004 21:00:44 -0000 > To: > Subject: Re: vacuoles > > > Tks, Laurie, for this clarification. I'm obviously not a biologist. > I only know that vacuoles have been reported as abnormal pathology > in muscle biopsies and associated with various muscle diseases. The > adjective I've seen most often is " rimmed " but adjectives are not > always used. I'm puzzled as to why any pathologist would report a > vacuole as a significant finding if all cells contain them? Beats > me. > > Barbara > > >>>> Dear Friends, >>> >>>> In 1999, they found a vacuole, which Dr. Hirano from Columbia > said >>> was >>>> very " unusual. " I have read since that vacuoles are common in >>>> inclusion-body myositis. My endo,who gave me a provisional dx of >>> mito in >>>> 1998, still thinks that I may have some form of myositis. But my >>>> deafness fits the mito pattern much more closely. >>> >>> Vacuoles (holes) can be found in various muscle diseases. I have >>> seen reports of vacuoles in lipid storage disorders, McArdles, > and >>> also associated with COX deficient fibers. This in addition to >>> inclusion-body myositis, which you mentioned. In an abstract of a >>> 2001 review of 113 muscle biopsies in patients with definite > MITO or >>> presumed MITO, vacuoles were not specifically mentioned, but the >>> study did find increased glycogen deposition and lipid > accumulation >>> in multiple patients, and those excesses can accumulate in > vacuoles. >>> The full-length article (which I have not seen) may clarify > whether >>> the excess glycogen and lipid was associated with vacuoles in > those >>> mito cases. >>> >>> Hope the biopsy goes well and that you get some useful > information. >>> Barbara >>> >>> >>> >>> >>> >>> Medical advice, information, opinions, data and statements > contained herein >>> are not necessarily those of the list moderators. The author of > this e mail is >>> entirely responsible for its content. List members are reminded > of their >>> responsibility to evaluate the content of the postings and > consult with their >>> physicians regarding changes in their own treatment. >>> >>> Personal attacks are not permitted on the list and anyone who > sends one is >>> automatically moderated or removed depending on the severity of > the attack. >>> >>> >>> >>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Christie told me today they started studing cells in her biology class. Too bad they don't have a text book to look in other than one set for the entire school. Laureta Fitzgerald wrote: >Barbara > >Beats me too! > >I've helped my students to make cell models and it always a challenge to >create empty space. Balloons that are little and have just a little air in >them has helped. I guess it is time to pull a biology book off my shelf and >check it out. > >laurie > > > >> >>Reply-To: >>Date: Thu, 07 Oct 2004 21:00:44 -0000 >>To: >>Subject: Re: vacuoles >> >> >>Tks, Laurie, for this clarification. I'm obviously not a biologist. >>I only know that vacuoles have been reported as abnormal pathology >>in muscle biopsies and associated with various muscle diseases. The >>adjective I've seen most often is " rimmed " but adjectives are not >>always used. I'm puzzled as to why any pathologist would report a >>vacuole as a significant finding if all cells contain them? Beats >>me. >> >>Barbara >> >> >>>> >>>> >>>>>Dear Friends, >>>>> >>>>> >>>>>In 1999, they found a vacuole, which Dr. Hirano from Columbia >>>>> >>>>> >>said >> >> >>>>was >>>> >>>> >>>>>very " unusual. " I have read since that vacuoles are common in >>>>>inclusion-body myositis. My endo,who gave me a provisional dx of >>>>> >>>>> >>>>mito in >>>> >>>> >>>>>1998, still thinks that I may have some form of myositis. But my >>>>>deafness fits the mito pattern much more closely. >>>>> >>>>> >>>>Vacuoles (holes) can be found in various muscle diseases. I have >>>>seen reports of vacuoles in lipid storage disorders, McArdles, >>>> >>>> >>and >> >> >>>>also associated with COX deficient fibers. This in addition to >>>>inclusion-body myositis, which you mentioned. In an abstract of a >>>>2001 review of 113 muscle biopsies in patients with definite >>>> >>>> >>MITO or >> >> >>>>presumed MITO, vacuoles were not specifically mentioned, but the >>>>study did find increased glycogen deposition and lipid >>>> >>>> >>accumulation >> >> >>>>in multiple patients, and those excesses can accumulate in >>>> >>>> >>vacuoles. >> >> >>>>The full-length article (which I have not seen) may clarify >>>> >>>> >>whether >> >> >>>>the excess glycogen and lipid was associated with vacuoles in >>>> >>>> >>those >> >> >>>>mito cases. >>>> >>>>Hope the biopsy goes well and that you get some useful >>>> >>>> >>information. >> >> >>>>Barbara >>>> >>>> >>>> >>>> >>>> >>>>Medical advice, information, opinions, data and statements >>>> >>>> >>contained herein >> >> >>>>are not necessarily those of the list moderators. The author of >>>> >>>> >>this e mail is >> >> >>>>entirely responsible for its content. List members are reminded >>>> >>>> >>of their >> >> >>>>responsibility to evaluate the content of the postings and >>>> >>>> >>consult with their >> >> >>>>physicians regarding changes in their own treatment. >>>> >>>>Personal attacks are not permitted on the list and anyone who >>>> >>>> >>sends one is >> >> >>>>automatically moderated or removed depending on the severity of >>>> >>>> >>the attack. >> >> >>>> >>>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Muscle Biopsy and the Pathology of Skeletal Muscle http://www.emedicine.com/neuro/topic230.htm#target42 This is a peer-reviewed article on muscle biopsies and their interpretation. It has several references to vacuoles, including an image, if anyone is interested. One quote: " Several fibers contain numerous clear vacuoles on this H&E cross-section from a patient with colchicine myopathy. Vacuoles can be observed in a variety of situations, including glycogen storage disease, critical care myopathy, and periodic paralyses. Vacuoles also are observed as freezing artifact in sections that have been frozen with poor technique. " Barbara > >>>> > >>>> > >>>>>Dear Friends, > >>>>> > >>>>> > >>>>>In 1999, they found a vacuole, which Dr. Hirano from Columbia > >>>>> > >>>>> > >>said > >> > >> > >>>>was > >>>> > >>>> > >>>>>very " unusual. " I have read since that vacuoles are common in > >>>>>inclusion-body myositis. My endo,who gave me a provisional dx of > >>>>> > >>>>> > >>>>mito in > >>>> > >>>> > >>>>>1998, still thinks that I may have some form of myositis. But my > >>>>>deafness fits the mito pattern much more closely. > >>>>> > >>>>> > >>>>Vacuoles (holes) can be found in various muscle diseases. I have > >>>>seen reports of vacuoles in lipid storage disorders, McArdles, > >>>> > >>>> > >>and > >> > >> > >>>>also associated with COX deficient fibers. This in addition to > >>>>inclusion-body myositis, which you mentioned. In an abstract of a > >>>>2001 review of 113 muscle biopsies in patients with definite > >>>> > >>>> > >>MITO or > >> > >> > >>>>presumed MITO, vacuoles were not specifically mentioned, but the > >>>>study did find increased glycogen deposition and lipid > >>>> > >>>> > >>accumulation > >> > >> > >>>>in multiple patients, and those excesses can accumulate in > >>>> > >>>> > >>vacuoles. > >> > >> > >>>>The full-length article (which I have not seen) may clarify > >>>> > >>>> > >>whether > >> > >> > >>>>the excess glycogen and lipid was associated with vacuoles in > >>>> > >>>> > >>those > >> > >> > >>>>mito cases. > >>>> > >>>>Hope the biopsy goes well and that you get some useful > >>>> > >>>> > >>information. > >> > >> > >>>>Barbara > >>>> > >>>> > >>>> > >>>> > >>>> > >>>>Medical advice, information, opinions, data and statements > >>>> > >>>> > >>contained herein > >> > >> > >>>>are not necessarily those of the list moderators. The author of > >>>> > >>>> > >>this e mail is > >> > >> > >>>>entirely responsible for its content. List members are reminded > >>>> > >>>> > >>of their > >> > >> > >>>>responsibility to evaluate the content of the postings and > >>>> > >>>> > >>consult with their > >> > >> > >>>>physicians regarding changes in their own treatment. > >>>> > >>>>Personal attacks are not permitted on the list and anyone who > >>>> > >>>> > >>sends one is > >> > >> > >>>>automatically moderated or removed depending on the severity of > >>>> > >>>> > >>the attack. > >> > >> > >>>> > >>>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Dear Barbara, Thanks for your usual, very useful information. It certainly is complicated, this disease, but your postings always add some light onto the subject. Will keep you posted, and thank you to you and to Laurie for your conversation about vacuoles. Maybe there should be some nominations for some lesser form of the Nobel Prize for medicine being bandied about on the mito lists! We seem to be forever immersed in some form of research, and most of us graduated many moons ago. Take care. S. PA Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2004 Report Share Posted October 7, 2004 Dear Barbara, THANKS so much for the excellent article about muscle biopsies and their interpretations. It is the best I have ever read, a " keeper. " Gratefully, Quote Link to comment Share on other sites More sharing options...
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