Guest guest Posted February 22, 2004 Report Share Posted February 22, 2004 Avoid alcohol completely as methotrexate and alcohol can cause irreversible damage to the liver leading to cirrhosis. Are there interactions with other drugs while taking methotrexate? An interaction generally means that one drug may increase or decrease the effect of another drug. Also, the more medications a person takes, the more likely there will be a drug interaction. Interactions with this drug may occur with the following: alcohol (leads to liver toxicity) digoxin (Lanoxin) phenytoin (Dilantin) aspirin or other salicylates arthritis drugs (ibuprofen, Advil, Motrin, Naprosyn, Voltaren, Lodine) probenecid bismuth subsalicylate (Pepto Bismol) carbenicillin (Geocillin) cholestyramine (Questran) sulfa drugs (Bactrim) cyclosporine (Sandimmune, Neoral) etretinate (Tegison) thiazide diuretics (Dyazide, hydrochlorothiazide) blood thinners (Coumadin) azathioprine (Imuran) Quote Link to comment Share on other sites More sharing options...
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