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http://www.cnn.com/HEALTH/conditions>

Heart tumors might be more common

Condition itself isn't dangerous but could cause strokes

Thursday, July 29, 2004 Posted: 9:25 AM EDT (1325 GMT)

You Can Cut Your Risk of Heart Disease

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Cut your risk of heart disease by controlling homocysteine levels.

Trivita...

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Innovative Heart Disease Treatment

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The Cleveland Clinic offers information about heart disease and

comprehensive...

www.clevelandclinic.org

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Angioprim Cleans Blocked Arteries

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Angioprim is an effective way to reverse heart disease, control

arthritis,...

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Heart Disease: A.M.P. Molo-Cure

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Heart disease - Doctors, patients and researchers worldwide are talking

about...

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HEALTH LIBRARY

http://www.cnn.com/mayo>

.. Health Library http://www.cnn.com/HEALTH/library>

.. Heart and Blood http://www.cnn.com/HEALTH/library/heart.blood/>

RELATED

.

Interactive: Tumors that are not so benign

.. New England Journal of Medicine http://www.nejm.com>

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| What is this?

(AP) -- Scientists studying a rare genetic disorder have made a

surprising discovery that helps explain why certain heart tumors develop

and suggests they may be more common than had been believed.

Doctors should look more broadly for signs of such tumors, which aren't

cancerous but are dangerous because they can break off and cause

strokes, researchers say.

" This may be more widespread than we had ever thought, " said Dr. Jil

Tardiff, a cardiologist at Albert Einstein College of Medicine in New

York who reviewed the research that was reported in Thursday's New

England Journal of Medicine.

The work was led by Dr. Craig Basson, a cardiologist at Weill Medical

College of Cornell University, and involved four other hospitals in the

United States and two in Belgium.

They studied a large Belgian family with 18 members who had a muscle

disorder that caused spotty skin pigmentation, tight or clenched hands

and feet, and an inability to open their jaws fully. Three also had

heart tumors called myxomas, which affect one of every 100,000 people

each year.

" Anybody who's a cardiologist has seen one, " Basson said of such tumors.

No one had connected them to muscle disorders, but Basson suspected a

link. He surprisingly found it in myosin, a group of proteins with an

array of important jobs, including making muscles contract.

Defects in myosin genes are known to cause disorders such as Usher

syndrome, the leading cause of blindness and deafness in young children.

A decade ago, they were linked to sudden cardiac death in young people.

The gene defect Basson identified is very similar to some of the

mutations that cause sudden cardiac death -- an " unexpected and

exciting " discovery, Tardiff wrote.

" It makes us think more broadly " about who may have heart tumors, and to

suspect the condition in people with other muscle disorders or unusual

orthopedic symptoms like the clenched hands, Tardiff said. " Many people

think it's underdiagnosed. "

Now that the cause of such tumors is known, scientists can try to design

treatments like drugs and gene therapy as alternatives to surgery, the

only treatment for them now, Basson said.

The discovery also could have implications for the field of stem cell

biology. The myosin defect Basson identified is in a gene that was

thought to stop functioning shortly after birth. His work shows it may

keep going to some degree in some people, which he views as evidence

that there's a type of stem cell in the adult heart, a widely debated

theory.

The National Institutes of Health funded the study.

------------------------------------------------------------------------

Copyright 2004 The Associated Press

http://www.cnn.com/interactive_legal.html#AP>. All rights reserved.This

material may not be published, broadcast, rewritten, or redistributed.

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