Journal Articles about CoQ10?

[Guest guest]

I have been going back and forth with Masshealth (Medicaide) about

paying for Austen's CoQ10. After being denied the second time I was

given the opportunity to appeal. I got bold and sent in a letter of

appeal. Much to my surprise I just got a letter back from Masshealth

saying that they WOULD pay for it as long as I had doctors appeals

(no problem) and articles about CoQ10 which would substantiate the

fact that it has been found to be very helpful for mito disorders.

There is no question that it has helped Austen enormously as far as

cognitive reasoning. Does anyone have any articles available on it's

benefits and how it works?

I appreciate any help.

Thanks,

Gwen

mom to Austen GA2 age 6

[Guest guest]

I might suggest you visit your local health food store. A lot of times they will have different brochures on benefits of each vitamin/supplement.

I was wondering how much you all typically pay for your CoQ10? Our chiropractor is able to order from different companies and she orders mine at cost for me. I still think it's rather expensive though. She orders from Metagenics and it's $36.00 (cost) for 60 100mg softgels. It also has 100iu of Vitamin E. I am trying to remember if I read something in a previous post about a company offering a big discount to mito customers. (Maybe I was just dreaming...)

One more question while I am here. Does anyone have problems with their children waking up for hours in the middle of the night? Lindsey will sometimes be awake for up to 3 hours in the middle of the night. She doesn't seem to be in any pain, she just doesn't sleep. I wouldn't think anything of it but, she does it sometimes 3-4 times per week.

Thanks!

Kim - Mommy to and Lindsey (20 months) Complex I and IV

Journal Articles about CoQ10?

I have been going back and forth with Masshealth (Medicaide) about paying for Austen's CoQ10. After being denied the second time I was given the opportunity to appeal. I got bold and sent in a letter of appeal. Much to my surprise I just got a letter back from Masshealth saying that they WOULD pay for it as long as I had doctors appeals (no problem) and articles about CoQ10 which would substantiate the fact that it has been found to be very helpful for mito disorders. There is no question that it has helped Austen enormously as far as cognitive reasoning. Does anyone have any articles available on it's benefits and how it works? I appreciate any help.Thanks,Gwenmom to Austen GA2 age 6Please contact mito-owner with any problems or questions.

[Guest guest]

Kim,

If she has sleep apnea it might be that. I read it as a symptom once and I identify with it. I wake up with a start and I am WIDE awake and have learned all I can do is get up and do stuff for 2-4 hours. Then I get sleepy again and sack out (unless it's time to get up for the day in which case I'm really dragging).

Scoggins

Journal Articles about CoQ10?

I have been going back and forth with Masshealth (Medicaide) about paying for Austen's CoQ10. After being denied the second time I was given the opportunity to appeal. I got bold and sent in a letter of appeal. Much to my surprise I just got a letter back from Masshealth saying that they WOULD pay for it as long as I had doctors appeals (no problem) and articles about CoQ10 which would substantiate the fact that it has been found to be very helpful for mito disorders. There is no question that it has helped Austen enormously as far as cognitive reasoning. Does anyone have any articles available on it's benefits and how it works? I appreciate any help.Thanks,Gwenmom to Austen GA2 age 6Please contact mito-owner with any problems or questions.

[Guest guest]

Is there anything on the mito associations websites? Or from any company

that makes the CoQ10? Call the company you buy yours from, they'll want to

keep making money off you so they are very likely to help you with articles

to substantiate it's use although there might be a conflict of some sort

(you know, all the legal garbage).

Scoggins

Journal Articles about CoQ10?

> I have been going back and forth with Masshealth (Medicaide) about

> paying for Austen's CoQ10. After being denied the second time I was

> given the opportunity to appeal. I got bold and sent in a letter of

> appeal. Much to my surprise I just got a letter back from Masshealth

> saying that they WOULD pay for it as long as I had doctors appeals

> (no problem) and articles about CoQ10 which would substantiate the

> fact that it has been found to be very helpful for mito disorders.

> There is no question that it has helped Austen enormously as far as

> cognitive reasoning. Does anyone have any articles available on it's

> benefits and how it works?

> I appreciate any help.

> Thanks,

> Gwen

> mom to Austen GA2 age 6

>

>

>

>

> Please contact mito-owner with any problems or questions.

>

>

[Guest guest]

Hi Kim:

I have a daughter, Leah, who is 5 years old. She still wakes up

in the middle of the night but some times for only a little bit.

Many times I just need to crawl in to bed with her and she goes back to

bed right away. We have a double bed and we both get the needed sleep.

When she does sleep through the night I rejoice because I get good solid

sleep.

As for CoQ10 I get maxi-sorb from Country Life at a health food store.

It is 30 mg for now and there are 50 softgels in a bottle. Leah takes

this twice a day. There is 6 I>U> of vitamin E in there. We

pay $29.95 for two bottles of Country Life. I get all

of Leah's supplements from the health food store because I feel I'm getting

pure stuff and no extra ingredients like unneccessary dyes and stuff like

that.

Nerenhausen

mom to Leah

Kim Novy wrote:

I

might suggest you visit your local health food store. A lot of times

they will have different brochures on benefits of each vitamin/supplement. I

was wondering how much you all typically pay for your CoQ10? Our

chiropractor is able to order from different companies and she orders mine

at cost for me. I still think it's rather expensive though.

She orders from Metagenics and it's $36.00 (cost) for 60 100mg softgels.

It also has 100iu of Vitamin E. I am trying to remember if

I read something in a previous post about a company offering a big discount

to mito customers. (Maybe I was just dreaming...) One

more question while I am here. Does anyone have problems with their

children waking up for hours in the middle of the night? Lindsey

will sometimes be awake for up to 3 hours in the middle of the night.

She doesn't seem to be in any pain, she just doesn't sleep. I wouldn't

think anything of it but, she does it sometimes 3-4 times per week. Thanks!Kim

- Mommy to and Lindsey (20 months) Complex I and IV

Journal Articles about

CoQ10?

I have been going back and forth with Masshealth (Medicaide)

about

paying for Austen's CoQ10. After being denied the second time I

was

given the opportunity to appeal. I got bold and sent in a letter

of

appeal. Much to my surprise I just got a letter back from Masshealth

saying that they WOULD pay for it as long as I had doctors appeals

(no problem) and articles about CoQ10 which would substantiate

the

fact that it has been found to be very helpful for mito disorders.

There is no question that it has helped Austen enormously as far

as

cognitive reasoning. Does anyone have any articles available on

it's

benefits and how it works?

I appreciate any help.

Thanks,

Gwen

mom to Austen GA2 age 6

Please contact mito-owner with any problems or questions.

[Guest guest]

Kim,

I meant to add that I've gotten very little sleep in life anyway. First it was my leg cramps, enuresis, and abuse. Then it was my kids, then the grandkids, and now even my husband. I don't think God meant for me to sleep! Even my kids-in-law have had me up during the night for some crisis or another.

Remember that ADHD is a mito disorder (at least many of the mito doctors think so and feel it may be the precursor to Alzheimer's) and look how little people with ADHD sleep.

Nightmares, sleepwalking and sleep talking are all common at our house too.

I read that nightmares can be associated with sleep apnea too.

Scoggins

Journal Articles about CoQ10?

I have been going back and forth with Masshealth (Medicaide) about paying for Austen's CoQ10. After being denied the second time I was given the opportunity to appeal. I got bold and sent in a letter of appeal. Much to my surprise I just got a letter back from Masshealth saying that they WOULD pay for it as long as I had doctors appeals (no problem) and articles about CoQ10 which would substantiate the fact that it has been found to be very helpful for mito disorders. There is no question that it has helped Austen enormously as far as cognitive reasoning. Does anyone have any articles available on it's benefits and how it works? I appreciate any help.Thanks,Gwenmom to Austen GA2 age 6Please contact mito-owner with any problems or questions.

[Guest guest]

Hi Kim and , Zack takes the CoQ 2x/day each at 30mg. We get ours from GNC..and it can be ordered online. We pay $24.99 for 120 softgels that I stick w/ a needle and squirt into his carnitor so it doesn't get stuck on a spoon. Other ingredients listed are soybean oil, gelatin, glycerin, chlorophyll, and titanium dioxide(natural mineral whitener). Also has anyone checked out coral calcium? This is suppose to help remove the free radicals that make us sick and our kids! I continue to hear awesome stories about this. My husband was even stationed in Okinawa where he saw that people lived there longer and were a lot healthier...people think it's due to the coral calcium found there. Check out the site. http://www.robert-barefoot-calcium.com/ If anyone has heard of this let me know, I have been thinking about trying it. Mom to Zachary 3yrs old (SCAD Variant and Complex 1 def.) 4 1/2 yrs old and not tested Journal Articles about CoQ10? I have been going back and forth with Masshealth (Medicaide) about paying for Austen's CoQ10. After being denied the second time I was given the opportunity to appeal. I got bold and sent in a letter of appeal. Much to my surprise I just got a letter back from Masshealth saying that they WOULD pay for it as long as I had doctors appeals (no problem) and articles about CoQ10 which would substantiate the fact that it has been found to be very helpful for mito disorders. There is no question that it has helped Austen enormously as far as cognitive reasoning. Does anyone have any articles available on it's benefits and how it works? I appreciate any help. Thanks, Gwen mom to Austen GA2 age 6 Please contact mito-owner with any problems or questions.

[Guest guest]

Kim,

We buy our CoQ10 from walmart for 11.94 for 30 100mg tablets. Dr. Cohen tested it and said it was fine. My daughter takes 200 mg a day and that is the best price that I have found. Every once in awhile Vitamin world will have a sale and then I buy it from them.

My daughters name is also Lindsey and she used to wake up at night just about every night. She would also stay up for hours. She is 7 now and doesn't do that anymore. She stopped about 2 years ago.

Amy (mother to Lindsey complex IV, hypertrophic cardiomyopathy, lactic acidosis)

Journal Articles about CoQ10?

I have been going back and forth with Masshealth (Medicaide) about paying for Austen's CoQ10. After being denied the second time I was given the opportunity to appeal. I got bold and sent in a letter of appeal. Much to my surprise I just got a letter back from Masshealth saying that they WOULD pay for it as long as I had doctors appeals (no problem) and articles about CoQ10 which would substantiate the fact that it has been found to be very helpful for mito disorders. There is no question that it has helped Austen enormously as far as cognitive reasoning. Does anyone have any articles available on it's benefits and how it works? I appreciate any help.Thanks,Gwenmom to Austen GA2 age 6Please contact mito-owner with any problems or questions.

[Guest guest]

Kim, used to be awake in middle of the night for hours. It did start the day after his fourth set of vaccines. And it was every night for 8 mos. He was awake, not seeming to be ill, just awake. We rocked and he ate and so forth and nothing I did helped. He would be up 4-5 hours. He did not make it up during the day. When I look back at pictures it is obvious his brain was swollen. Really obvious. Even now when he no longer looks that way, his EEG states chronic encephalopathy. One night while up he had a serious (eyes rolled back, etc.) and then the next night he went back to sleeping through the night - like he had done prior to the shots at 13 mos. of age.

The only other times I noticed night waking since then was when I would try to adjust his nutrient levels, etc. with vitamins and minerals. I was doing this on my own as we could not get appropriate testing done at the time, so I had no idea what I was doing, but was desperate. Had to move to a different state for relevant testing - no longer working on my own, thank goodness!

cara

-----Original Message-----From: Kim Novy Sent: Monday, June 02, 2003 6:55 PMTo: Mito Subject: Re: Journal Articles about CoQ10?

I might suggest you visit your local health food store. A lot of times they will have different brochures on benefits of each vitamin/supplement.

I was wondering how much you all typically pay for your CoQ10? Our chiropractor is able to order from different companies and she orders mine at cost for me. I still think it's rather expensive though. She orders from Metagenics and it's $36.00 (cost) for 60 100mg softgels. It also has 100iu of Vitamin E. I am trying to remember if I read something in a previous post about a company offering a big discount to mito customers. (Maybe I was just dreaming...)

One more question while I am here. Does anyone have problems with their children waking up for hours in the middle of the night? Lindsey will sometimes be awake for up to 3 hours in the middle of the night. She doesn't seem to be in any pain, she just doesn't sleep. I wouldn't think anything of it but, she does it sometimes 3-4 times per week.

Thanks!

Kim - Mommy to and Lindsey (20 months) Complex I and IV

Journal Articles about CoQ10?

I have been going back and forth with Masshealth (Medicaide) about paying for Austen's CoQ10. After being denied the second time I was given the opportunity to appeal. I got bold and sent in a letter of appeal. Much to my surprise I just got a letter back from Masshealth saying that they WOULD pay for it as long as I had doctors appeals (no problem) and articles about CoQ10 which would substantiate the fact that it has been found to be very helpful for mito disorders. There is no question that it has helped Austen enormously as far as cognitive reasoning. Does anyone have any articles available on it's benefits and how it works? I appreciate any help.Thanks,Gwenmom to Austen GA2 age 6Please contact mito-owner with any problems or questions.

[Guest guest]

Hope this article helps.

http://www.coenzymeq10supplement.com/brain-cells-coenzymeq10.htm

_________________________________________________________________

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[Guest guest]

http://www.coenzymeq10supplement.com/references.htm

Benefits of CoenzymeQ10 in Treatment of Mitochondrial and Neuromuscular

Diseases:

--------------------------------------------------------------------------------

Since the discovery of the first genetic disease of the mitochondria in

1988, the number of recognized mitochondrial diseases has ballooned. These

diseases present extraordinarily complicated genetic and clinical pictures

that cut across established diagnostic categories. They primarily affect the

brain, nerve, muscle, heart, kidney and endocrine system, whose high energy

requirements can no longer be fully met. In addition, a wide range of

degenerative diseases have been found to involve one or more of hundreds of

known mitochondrial mutations.

Patients with genetic Coenzyme Q10 deficiency may suffer dysfunctions in

brain, nerve and muscle, often including exertional fatigue and seizures.

Such patients appear to respond to Coenzyme Q10 supplementation, but

observations are limited since diagnosis of this disorder is in its infancy.

Coenzyme Q10 deficiency is one of the mitochondrial diseases caused by

mutations in non-mitochondrial DNA, that is DNA in the cell nucleus.

Case reports and pilot studies have found that some patients with

mitochondrial diseases respond to long-term Coenzyme Q10 therapy. For

example, promising results have been reported in MELAS, Kearns-Sayre

syndrome and maternally inherited diabetes with deafness. An Italian study

demonstrated the impact of Coenzyme Q10 therapy on the living tissue of six

patients with mitochondrial cytopathies. They measured the bioenergetic

activity in the brain and skeletal muscle of the patients using

high-technology diagnostic equipment (phosphorus magnetic resonance

spectroscopy). After six months of Coenzyme Q10 therapy at 150 mg per day,

brain bioenergetics returned to normal in all patients, and skeletal muscle

energetics improved significantly. A new study applies this diagnostic

technology to Friedrich’s Ataxia, which is characterized by a deficiency of

a mitochondrial protein called frataxin recently discovered to activate

cellular respiration. The study found that supplementation with Coenzyme Q10

plus vitamin E brought a “dramatic improvement of cardiac and skeletal

muscle bioenergetics. . . after only three months of therapy” (Lodi R et

al., 2001)1. A just-published study of familial ataxias with no known

genetic cause reports that Coenzyme Q10 supplementation improved patients’

scores by 25% on a scale measuring balance, speech and movement. The five

patients who could not walk at the beginning of the trial were able to walk

with some assistance after supplementation (dose levels varied).

Since all cells (except red blood cells) contain mitochondria, mitochondrial

diseases tend to affect multiple body systems. Of course some organs and

tissues depend more than others upon the energy the mitochondria produce.

At the genetic level, the picture is more complex. The level of inherited

mitochondrial DNA defects may establish an individual’s “bioenergetic

baseline.” As additional mitochondrial DNA defects develop over the course

of a lifetime, bioenergetic capacity may decline until thresholds are

crossed where organs malfunction or become susceptible to degeneration.

Another genetic complication is that each mitochondrion contains many copies

of mitochondrial DNA, and each cell and tissue contains many mitochondria.

At both these levels, there may be many different defects in different

copies of the mitochondrial genome. This is especially true of the defects

that cause clinical pathologies.

For a particular tissue or organ to become dysfunctional, a critical number

of its mitochondrial DNA’s must be mutated. This is called the “threshold

effect.” Each organ or tissue is more susceptible to some mutations than

others and has its own particular mutational threshold, energy requirement

and sensitivity to oxidative stress. All these factors combine to determine

how it will respond to genetic damage. The picture is further complicated by

interactions between DNA in mitochondria and in the cell nucleus. The result

is that the same mitochondrial DNA mutations can produce remarkably

different symptoms in members of the same family, while different mutations

can produce the same symptoms.

Some of the specific mitochondrial mutations found in mitochondrial diseases

develop spontaneously in the aged. More generally, the picture we have

sketched of mitochondrial disease illuminates the consequences of Linnane’s

theory: it helps explain how mitochondrial mutation-driven bioenergetic

decline can have such varied and complex effects over the course of aging.

There is a heterogeneous group of neuromuscular disorders whose exact cause

and effective treatment remain largely unknown. These include muscular

dystrophy, some encephalomyopathies and various neurogenic atrophies.

Several small trials and case reports suggest that some patients with these

diseases respond to Coenzyme Q10 therapy.

Coenzyme Q10 pioneer Karl Folkers observed that cardiovascular disorders are

associated with these conditions, as might be expected if cellular energy

production were impaired. He therefore conducted a double-blind trial to

assess the effect of Coenzyme Q10 on cardiac performance in patients with

muscular dystrophies and neurogenic atrophies. After three months of

treatment with 100 mg of Coenzyme Q10 per day, cardiac function was

significantly improved in all patients and half the patients showed distinct

improvement in movement and exercise capacity. Folkers hypothesized that

these conditions have in common a deficiency of Coenzyme Q10.

By the same token, mitochondrial defects may contribute to heart disease in

some patients. A recent study of dilated cardiomyopathy found that about one

in four patients had pathological mutations in the mitochondrial DNA of

heart tissue.

See References

CoQ10 Researh References:

--------------------------------------------------------------------------------

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