pyruvate/lactate testing question

[Guest guest]

Hi Folks,

I have a question about lactate and pyruvate testing (especially cause

they did mine wrong at the lab).

I have read that for the lactate test to be valid the tourniquet must be

released before blood is sampled. Does that mean they can use a

tourniquet, but it just has to be taken off before the vein is

punctured?

I have read for the pyruvate test the specimen be instantly deprotinized

(5 seconds I think I read). Someplace I thought I read the same thing

about the tourniquet with the pyruvate test, but now can't find where I

THOUGHT I read it. Anybody know?

Because I don't understand a whole lot of the biochemistry of mito

diseases yet, I need some guidance in putting together little pieces of

info I've found in different places. Within the framework of testing for

mito diseases (or maybe just with Pyruvate Dehydrogenase Complex

Deficiency where carbs are a big NO NO), does one have to actually be

eating carbs in order for the lactate and pyruvate tests to be valid. It

would seem to me that if eating carbs is one of the things that raises

the

lactate and pyruvate levels in the blood (at least in PDCD), then if you

aren't eating any ( almost none) it might be tough to nail a high

level, even if PCDC

existed.

Appreciate your thoughts on this one.

Thanks,

Anita

[Guest guest]

Anita

I have been told that you can use a tourniquet as long as it is released,

but I have good veins and request that they do it without. Both my lactate

and pyruvate are in the normal range, but the ratio is not.

That is a good question about diet affecting the levels. I have not run

across that before, so don't have a clue. I do know that with a complex I

defect, logic says to eat more fat, but that doesn't help for most people.

laurie

>

> Organization:

> Reply-To:

> Date: Tue, 11 May 2004 13:55:27 -0400

> To: >

> Subject: pyruvate/lactate testing question

>

> Hi Folks,

>

> I have a question about lactate and pyruvate testing (especially cause

> they did mine wrong at the lab).

>

> I have read that for the lactate test to be valid the tourniquet must be

>

> released before blood is sampled. Does that mean they can use a

> tourniquet, but it just has to be taken off before the vein is

> punctured?

>

>

> I have read for the pyruvate test the specimen be instantly deprotinized

>

> (5 seconds I think I read). Someplace I thought I read the same thing

> about the tourniquet with the pyruvate test, but now can't find where I

>

> THOUGHT I read it. Anybody know?

>

> Because I don't understand a whole lot of the biochemistry of mito

> diseases yet, I need some guidance in putting together little pieces of

>

> info I've found in different places. Within the framework of testing for

>

> mito diseases (or maybe just with Pyruvate Dehydrogenase Complex

> Deficiency where carbs are a big NO NO), does one have to actually be

> eating carbs in order for the lactate and pyruvate tests to be valid. It

>

> would seem to me that if eating carbs is one of the things that raises

> the

> lactate and pyruvate levels in the blood (at least in PDCD), then if you

>

> aren't eating any ( almost none) it might be tough to nail a high

> level, even if PCDC

> existed.

>

> Appreciate your thoughts on this one.

>

> Thanks,

> Anita

>

>

>

>

>

>

> Medical advice, information, opinions, data and statements contained herein

> are not necessarily those of the list moderators. The author of this e mail is

> entirely responsible for its content. List members are reminded of their

> responsibility to evaluate the content of the postings and consult with their

> physicians regarding changes in their own treatment.

>

> Personal attacks are not permitted on the list and anyone who sends one is

> automatically moderated or removed depending on the severity of the attack.

>

>

>

>

[Guest guest]

Hi Laurie, Thanks for your input about the tourniquet. Is that the

tourniquet info just for the lactate test , or also for the pyruvate,

too? Do you know where I can find info on interpreting the ratio? I

had read that the ratio was only important if the lactate was high,

but from what you have written I'm guessing that's not true?We're

pretty sure my test were done incorrectly, but I'd like to plug the

results in , anyhow.

I really appreciate all your info and guidance!

Thanks,

Anita

[Guest guest]

Anita

I can't give you the ratio and don't know about pyruvate draws. Mine was all

taken at the same time, so I really don't know. Mine was part of a urine

acid screen and blood amino acid screen. I keep being told that my low

values are insignificant, but I think in time they may change their minds. I

have 0 values (tested 3 times over several years) that have a range from say

100-300. More than half of my values are extremely low. Another unique

feature.

laurie

>

> Reply-To:

> Date: Tue, 11 May 2004 21:46:00 -0000

> To:

> Subject: Re: pyruvate/lactate testing question

>

> Hi Laurie, Thanks for your input about the tourniquet. Is that the

> tourniquet info just for the lactate test , or also for the pyruvate,

> too? Do you know where I can find info on interpreting the ratio? I

> had read that the ratio was only important if the lactate was high,

> but from what you have written I'm guessing that's not true?We're

> pretty sure my test were done incorrectly, but I'd like to plug the

> results in , anyhow.

>

> I really appreciate all your info and guidance!

>

> Thanks,

> Anita

>

>

>

>

>

>

> Medical advice, information, opinions, data and statements contained herein

> are not necessarily those of the list moderators. The author of this e mail is

> entirely responsible for its content. List members are reminded of their

> responsibility to evaluate the content of the postings and consult with their

> physicians regarding changes in their own treatment.

>

> Personal attacks are not permitted on the list and anyone who sends one is

> automatically moderated or removed depending on the severity of the attack.

>

>

>

>

[Guest guest]

Laurie, Thanks for the reply. You sure do sound like you have

some unique aspects to your health challenges. I prefer to think

of you as a very special woman in every way....and your unique

health challenges are just part of it :-)

Anita

[Guest guest]

Anita

Thank you very much!!

laurie

>

> Reply-To:

> Date: Wed, 12 May 2004 01:14:05 -0000

> To:

> Subject: Re: pyruvate/lactate testing question

>

> Laurie, Thanks for the reply. You sure do sound like you have

> some unique aspects to your health challenges. I prefer to think

> of you as a very special woman in every way....and your unique

> health challenges are just part of it :-)

>

> Anita

>

>

>

>

>

>

> Medical advice, information, opinions, data and statements contained herein

> are not necessarily those of the list moderators. The author of this e mail is

> entirely responsible for its content. List members are reminded of their

> responsibility to evaluate the content of the postings and consult with their

> physicians regarding changes in their own treatment.

>

> Personal attacks are not permitted on the list and anyone who sends one is

> automatically moderated or removed depending on the severity of the attack.

>

>

>

>