Guest guest Posted December 28, 2003 Report Share Posted December 28, 2003 terricecile wrote: > Are your fibroids small enough for a hysteroscopic resection? This > is an outpatient procedure with no incision, also known as a vaginal > myomectomy. they are 5cm 3cm and one 5 x 2 x 3 cm ...my gyn has not mentioned this as an option. I live in Vt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 28, 2003 Report Share Posted December 28, 2003 Could be that he isn't skilled or trained in hysteroscopic procedures. Many gyns are not. Unfortuantely it seems like most won't bother to refer patients to more experienced doctors and instead only offer procedures that they are trained in. > > > Are your fibroids small enough for a hysteroscopic resection? This > > is an outpatient procedure with no incision, also known as a vaginal > > myomectomy. > > they are 5cm 3cm and one 5 x 2 x 3 cm ...my gyn has not mentioned this > as an option. I live in Vt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2004 Report Share Posted January 6, 2004 Diane, I have not prescribed Mefipristone and have no personal experience with it. Dr. Steve Eisinger recently presented his data using it for fibroids and found a 45% reduction in fibroid volume and 60% of women stopped having periods. The 5 mg dose was just as effective as the higher dose, while the higher dose cause some abnormal overgrowth of the uterine lining cells (benign hyperplasia, but not pre-cancer or cancer). I am including the abstract from his recent publication below for you to look at. Steve has his e-mail listed, so you might try contacting him. I hope this of some help. Bill , MD Low-dose mifepristone for uterine leiomyomata. Eisinger SH, Meldrum S, Fiscella K, le Roux HD, Guzick DS. Obstet Gynecol. 2003 Feb;101(2):243-50 Rochester, New York, USA. eisinger@... OBJECTIVE: To compare the effect of 5 and 10 mg of mifepristone on uterine leiomyoma size and symptoms, and to measure side effects. METHODS: Forty premenopausal women with large, symptomatic leiomyomata were randomized to receive either 5 or 10 mg of mifepristone daily for 6 months in an open-label study. Uterine volume was measured at bimonthly intervals by sonography. Serum concentrations of hemoglobin levels, follicle-stimulating hormone, and liver enzymes were obtained, and endometrial samples, symptoms, and menstrual bleeding were also assessed. RESULTS: Nineteen of 20 subjects taking 5 mg and all 20 subjects taking 10 mg completed all 6 months of the study. Mean uterine volume shrank by 48% (P <.001) in the 5-mg group and 49% (P <.001) in the 10-mg group, a nonsignificant difference. Leiomyoma-related symptoms were comparably reduced in both groups. Amenorrhea occurred in 60-65% of both groups. Hemoglobin levels increased by 2.5 g/dL in anemic subjects. The incidence of hot flashes increased significantly over baseline in the 10-mg group but not in the 5-mg group. Simple endometrial hyperplasia occurred in 28% of all subjects, with no difference between groups. No atypical hyperplasia was noted. CONCLUSION: Mifepristone in doses of 5 mg or 10 mg results in comparable leiomyoma regression, improvement in symptoms, and few side effects. Further study is needed to assess the long-term safety and efficacy of low-dose mifepristone. Re: Re: my " gigantic " fibroid Dr , I am fairly new to this group, so please excuse me if you've already answered this question. How do you feel about mifepristone? Do you think that it will be available for fibroid treatment in the near future? Would you be prescribing it , and at what dose, if it were approved? I have the opportunity to travel to Europe where it is not as strictly controlled, to get 3 months supply at 5mgs per day.. thanks for your opinion Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2004 Report Share Posted January 7, 2004 Thank you...I have read the study and tried to get into the new one, but I live too far from Rochester NY. Will you be prescribing it in the future, given the good results with minimum side effects? RE: Re: my " gigantic " fibroid Diane, I have not prescribed Mefipristone and have no personal experience with it. Dr. Steve Eisinger recently presented his data using it for fibroids and found a 45% reduction in fibroid volume and 60% of women stopped having periods. The 5 mg dose was just as effective as the higher dose, while the higher dose cause some abnormal overgrowth of the uterine lining cells (benign hyperplasia, but not pre-cancer or cancer). I am including the abstract from his recent publication below for you to look at. Steve has his e-mail listed, so you might try contacting him. I hope this of some help. Bill , MD Quote Link to comment Share on other sites More sharing options...
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