VESTIBULITIS INFO Mast cells proliferation/ histamine etc.

[Guest guest]

Ladies, I'm just simply reposting some of Dee's good info for the newer ones on the group...~ChelleDeeTroll wrote: ====================== HI all, It is thought that a person with vestibulitis can have up to 10X's more MAST cells than the average person. Some think it's genetic and inborn. (, Hasaday, Ledger, etc.) others that external issues triggered that increase with chemical abuse

possibly with yeast meds. Just as a side note I remember one of the women who I think talked with or knows about Dr. Ledger as to what he might use if one did have the V pain gene with double alleles, she said this... ''One of his possible treatments are the herb Pfaffia paniculata (an herb also called "suma" or "Brazilian ginseng," although it is not a ginseng), which he says is pure interleukin-1 receptor antagonist" (and we do want to halt that interleukin 1 Dee). And he used to use VIOXX which today has been pulled from the market but Cipro may act similiar tho I myself wouldn't use that either as I feel it too may be banned eventually with it's side effects esp. for the heart) Just me, it's too

similiar to Vioxx. Here's a link that talks about the Mast cell proliferation, (I've lots of them).. http://www.medscape.com/viewarticle/493971_print A quick quote from that one, (it's basically an article about using Capsaicin cream for V pain but it says this.............> ''Vestibular tissue removed from women who underwent surgery for VVS has been analyzed for nerve fiber density and the presence of mast cells; a significant increase in both the number of mast cells and the number of intraepithelial nerve endings, which are coarse and thickened, was

reported.'' Here's another conclusion from this link. And you'll see those Mast cells again: http://intapp.medscape.com/px/medlineapp/getdoc?pmi=15249746 & cid=med it says in brief: ''The total nerve fiber area was ten times higher in vestibulitis patients than in controls. A significant positive correlation was found

between the total nerve fiber area and the number of mast cells in the vestibulitis group of patients. Conclusion: (1) the presence of eight or more mast cells per 10 x 10 microscopic field, and (2) the total calculated area of the nerve fibers is ten times higher than expected.'' And another here that talks about the nerve bundle proliferation in vestibulitis. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=9540943 & dopt=Abstract So Histamine (and other cytokines/inflammatories) which some of you may have heard us talk about comes from those very Mast cells mentioned above. That's why you'll also hear us talk about adding an 'anti'-histamine' to combat that, either Oral or topical to quiet that down. Histamine causes the itch, inflammation, swelling (edema) and more, and the sooner we get that under control the better. Here is a bit of information from what one doctor wrote that explains Vestibultitis I think quite well. NOTE. V V S stands for vulvar vestibutlitis

syndrome. ''VVS is characterized by:1) Redness of the vestibule 2) Point tenderness of the vestibule3) Pain upon entry (tampons, penis, finger, speculum, etc). But these are just symptoms, and in fact several different diseases can give these same symptoms. If you have these symptoms, and do ''not'' have any other known causes of these symptoms, then you probably have VVS. " (NOTE that means after ruling out specific disease conditions, bacterial, fungal, or LS or LP, Lyme, Diet like with Celiac, dermatitis etc. etc. ) Dee ''What causes those symptoms? These nerve ending are called "nociceptors" - Pain/stretch nerve endings which accounts for the

exquisite tenderness when even light touch is applied to the vestibule. In addition, this proliferation of nerve ending accounts for the redness and swelling that you may feel. How? When the nerves fire, they cause the blood vessels in the vestibular mucosa to dilate (open up) this brings increased blood to the vestibule and vulva causing redness, swelling, and increased discharge. There is a proliferation of mast cells in the vestibule. (Why I added so much at the top about Mast cells.) Dee Mast cells are white blood cells that are responsible for the body's allergic reactions. Mast cells secrete many different chemicals including histamine (which causes the itching and burning sensation), bradykinin and substance P which cause pain (note* and why capsaicen may be used, dee ), and NGF (nerve growth factor) this is probably the cause of the increased nerve endings for women with secondary Vestibulitis. It is NOT an inflammation of glands!It is NOT an infection!It is NOT caused by recurrent yeast infections, but...it may be caused by the medications used to treat yeast infections, but not by the yeast infections themselves. Women often mistakenly feel that they have recurrent yeast infections because they have "itching, burning and discharge" and because they are misdiagnosed by health care providers. In my experience 80-90% of women who are told that they have

recurrent yeast infections- do not." * Note: Dee here ....Not too long ago I also mentioned how far too often a woman is left with the impression that she was not able to get rid of a yeast infection and insists on more treatments often erroneously but what she really was left with (after a treatment) is too often the inflammation itself (NOT the yeast) and again why an antihistamine can be SO beneficial to put that histamine and other cytokines from those Mast cells back into remission and quiet things down. (Dee) CONTINUED with his piece... "I believe (with some scientific evidence to back up my assertion) that ''Primary VVS'' is a congenital problem (IE a "birth

defect") Women with primary VVS are born with too many nerve endings in the vestibule!...... And I believe ''Secondary VVS'' is caused by a persistent allergic reaction often to antifungal medications which are used WAY TOO liberally by woman - and their doctors. This persistent allergic reaction leads to mast cell proliferation-----> to NGF (nerve growth factor)------> to proliferation of nerve endings!"...... END........ Hope that helps. It's just a small part but the meat of vestibulitis basically or I should say the most recent theories. Hugs Dee~

[Guest guest]

Thanks for posting this. I do think what many of us digest does affect us.

I have not been burning and yesterday I had a HUGE SOY LATTE from Starbucks and yesterday afternoon my vulva was swollen sore and red! I have been taking Benedryl at night if I cheat and eat things that are triggers for me. Certain foods, soaps, etc. will trigger the burning. I guess for some people their allergies are in their noses and for some of us they are in our vulvas..UGH!

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