Guest guest Posted September 22, 2006 Report Share Posted September 22, 2006 What is the DQ information below? I don't understand what DQ2 and DQ8 mean. Thanks Re: Biopsy for celiac > > Our genetic bloodwork was done by Promithius Labs in CA--where the GI > sent the vial(s) (I can't remember if it was 1 or more at this > point.) > > NO, you do NOT need to be eating gluten. The test was $440 for us. > The rest was picked up by insurance. BIG " savings " over a > biopsy...Gabby's endoscopy was over $2000 for our part! I had myself DQ typed as a result of a control study. Did not event think to consider celiac disease until I did a search on DQ2 and DQ8 as part of that study. Later I was casually reading the top 15 papers and these papers at it was like reading off symptoms I had for many years. " What is the celiac [stuff]? " Most honest physicians will tell you that the biopsy, by itself, gives inconsistent results. DQ is another guide and antibodies are another guide. If you have the positive biopsy then you know, but if you don't other signs may cause you to suspect and change. Between 1952 and 1956 when the cause of CD was known and the biopsy was rare, the diagnosis for CD was to remove gluten for a month, observe, challenge and observe (If the patients reaction was not severe enough). Many patients after going gluten free for a month simply chose not to be rechallenged. If DQ typing leads you to go GF and this resolves most of the problem, it is therefore adequate. In 1950s the cases that were being seen were the most severe, life threatening situations, one expects positive biopsies. The problem with waiting on a positive biopsy is that much damage is done, particularly in late onset cases, by the time the biopsy is positive. In the Finnish study 2 of their 28 died, based on what they were talking about 1 of lymphoma. The damage to the stem cells in the GI tract has been examined, it is DNA damage and is akin to aging 2 or 3 years the GI tract for every year the lymphocytes are elevated. This is were the cancer risk comes from. > We were told the endoscopy/biopsy was the " gold standard " and shows > correct positive results/negative results for " most people " . Gold is afterall just another metal. > Uh, > Gabby's not one of them. You HAVE to have been eating gluten for a > while (3-6 months) for a " good " biopsy. You have to be eating gluten. Your histologist needs to be proficient at grading severity. The sample needs to come from a patch that exhibits disease. (Patchy atrophy was noted in 1957 and still many physicians ignore this false negative possibility) > The genetic blood work is > the " platinum " standard--it will tell you if you have the gene for > celiac or not. The first standard and the most important standard is that removal of wheat gluten reduces the symptoms and improves the quality of life for the affected individual. There are many paths to get there. If I had a test that could identify abnormal immunology in the gut on the first day, I would on that day stop eating gluten. There is no such test, in very young children if you are lucky you can get a diagnoses within 4 months. In adults, the studies to which I have referred show symptoms preceding obvious disease by 5 or 10 years. , and only DQ typing can predict whether removal of gluten would be effective or ineffective, at these earlier points . Its like a flag to the physician, if the patient has this DQ be aware that he/she may have a celiac condition. Although its most important use if for a sense of awareness in siblings, for those who may carry the gene to know they are at increased risk. > But, you can be gluten INTOLERANT and NOT have the gene. In that case, > the bloodwork won't tell you. Rarely. I have read these occurances are between 2 and 5% And when transhaplotypes are considered less than 2%. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 22, 2006 Report Share Posted September 22, 2006 What is as a endoscopy? That isn't the same as a biopsy is it? My son had a endoscopy and I have the report but I don't know how to read it. Re: Biopsy for celiac > > Our genetic bloodwork was done by Promithius Labs in CA--where the GI > sent the vial(s) (I can't remember if it was 1 or more at this > point.) > > NO, you do NOT need to be eating gluten. The test was $440 for us. > The rest was picked up by insurance. BIG " savings " over a > biopsy...Gabby's endoscopy was over $2000 for our part! I had myself DQ typed as a result of a control study. Did not event think to consider celiac disease until I did a search on DQ2 and DQ8 as part of that study. Later I was casually reading the top 15 papers and these papers at it was like reading off symptoms I had for many years. " What is the celiac [stuff]? " Most honest physicians will tell you that the biopsy, by itself, gives inconsistent results. DQ is another guide and antibodies are another guide. If you have the positive biopsy then you know, but if you don't other signs may cause you to suspect and change. Between 1952 and 1956 when the cause of CD was known and the biopsy was rare, the diagnosis for CD was to remove gluten for a month, observe, challenge and observe (If the patients reaction was not severe enough). Many patients after going gluten free for a month simply chose not to be rechallenged. If DQ typing leads you to go GF and this resolves most of the problem, it is therefore adequate. In 1950s the cases that were being seen were the most severe, life threatening situations, one expects positive biopsies. The problem with waiting on a positive biopsy is that much damage is done, particularly in late onset cases, by the time the biopsy is positive. In the Finnish study 2 of their 28 died, based on what they were talking about 1 of lymphoma. The damage to the stem cells in the GI tract has been examined, it is DNA damage and is akin to aging 2 or 3 years the GI tract for every year the lymphocytes are elevated. This is were the cancer risk comes from. > We were told the endoscopy/biopsy was the " gold standard " and shows > correct positive results/negative results for " most people " . Gold is afterall just another metal. > Uh, > Gabby's not one of them. You HAVE to have been eating gluten for a > while (3-6 months) for a " good " biopsy. You have to be eating gluten. Your histologist needs to be proficient at grading severity. The sample needs to come from a patch that exhibits disease. (Patchy atrophy was noted in 1957 and still many physicians ignore this false negative possibility) > The genetic blood work is > the " platinum " standard--it will tell you if you have the gene for > celiac or not. The first standard and the most important standard is that removal of wheat gluten reduces the symptoms and improves the quality of life for the affected individual. There are many paths to get there. If I had a test that could identify abnormal immunology in the gut on the first day, I would on that day stop eating gluten. There is no such test, in very young children if you are lucky you can get a diagnoses within 4 months. In adults, the studies to which I have referred show symptoms preceding obvious disease by 5 or 10 years. , and only DQ typing can predict whether removal of gluten would be effective or ineffective, at these earlier points . Its like a flag to the physician, if the patient has this DQ be aware that he/she may have a celiac condition. Although its most important use if for a sense of awareness in siblings, for those who may carry the gene to know they are at increased risk. > But, you can be gluten INTOLERANT and NOT have the gene. In that case, > the bloodwork won't tell you. Rarely. I have read these occurances are between 2 and 5% And when transhaplotypes are considered less than 2%. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 22, 2006 Report Share Posted September 22, 2006 One thing to remember about the gene test is that is only elevates your risk of having celiac it doesn't confirm or rule out celiac. Most Celiacs have DQ2 or 8 but not all - there are about 2% who don't have either. And there are a lot of people with DQ2 or 8 that don't appear to have CD. Also of note is that one lab (Specialty Labs I think) only classes the DQ2 variant where a1=0501,b1=0201. If you have a1=0201,b1=0201 which is also DQ2 then you would test negative if you do the workup for CD gene. Which is not what you get from say the Mayo Lab. At least that's what I get from their website and somewhat confirmed by my son (Mayo, he's DQ2=0201, 0201 an DQ8 both) and mine through Lab Corps who sent off to Specialty Lab and they just sent back I'm negative for both DQ2 and DQ8. Since I'm his biological mother I'm thinking that's how they classed mine negative (it also seems that's what it says on their website.) I personally think Specialty Labs is wrong but I'm not a CD geneticist and although I've read studies that state just DQ2 without qualifying which variant I can't get enough data to see...nor would I have enough clout to change it. Anyway I jsut thought I'd mention it for those that might be lab tested. (Entero just checks for the b1 component of the HLA DQ marker.) __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 23, 2006 Report Share Posted September 23, 2006 --- Gibert nlgibert@...> wrote: > What is the DQ information below? I don't > understand what DQ2 and DQ8 mean. There are two human genetic markers that are closely associated with Celiac Disease. Many people have these markers that don't have Celiacs tho..BUT about 95% of Celiacs do have one of these genes. These genes are called HLA DQ2 and HLA DQ8. So what does this mean? It means that IF you are having Celiac type problems and you DON'T have one of these two genetic markers that the probability of it being " classic " Celiac is probably less than 5%. If you are having Celiac type problems and you DO have one of these two genetic markers it still means you may or may not have Celiacs but your probability is higher. So it basically can " almost rule out " Celiacs and that's about it. Where it does come in handy also is if you have a biopsy proven " classic " Celiac that has a child. You can check to see which markers you child has inherited and monitor them for signs of Celiac and you have a better chance of getting them monitored also. (Also is good for other family members). If the child doesn't happen to have one of the markers you can " relax " your vigilance for Celiacs (ymmv). Of course there are other markers which " supposedly " indicate association with glucose intolerance too - not sure if there are many studies on these tho. Entero Labs has info on this. __________________________________________________ Quote Link to comment Share on other sites More sharing options...
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