Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with PSC

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J

Hepatol. 2006 Nov.

Analysis of MAdCAM-1 and ICAM-1

polymorphisms in 365 Scandinavian patients with primary sclerosing

cholangitis.

Bowlus

CL, Karlsen

TH, Broome

U, Thorsby

E, Vatn

M, Schrumpf

E, Lie

BA, Boberg

KM.

Division of Gastroenterology, University of California

Medical Center,

Sacramento, CA

BACKGROUND/AIMS: Mucosal addressin

cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant

homing of intestinal lymphocytes to the liver in primary sclerosing

cholangitis (PSC). Intercellular

adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of

PSC and the E/E genotype of the K469E polymorphism has been reported to be

associated with PSC susceptibility. The aims of this

study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of

ICAM-1 are associated with PSC in Scandinavia. METHODS: Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway

and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368

Norwegian bone marrow donors served as controls. RESULTS:

No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1

SNPs. Allele frequencies for these polymorphisms were

not significantly different between PSC patients with UC, UC patients and

healthy controls. CONCLUSIONS: Polymorphisms in

MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does

not influence PSC susceptibility in Scandinavia.

PMID:

16750586 [PubMed - indexed for MEDLINE]