Re: Depakote question-Bill

[Guest guest]

Lol, well being slightly (actually make that very) cynical meself on anything

relating to these AEDs, I can relate to that.....

2 diff issues really though - one is how the valproate is metabolised, broken

down and then excreted - that is the issue was told about and was

querying - like can this excretion process alter what we see as a urine ketone

reading, leading to possible inaccuracy concerning what is going on in the

bloodstream, which is after all what is reflected in the brain...

The other issue is how valproate itself interacts and/or 'competes' with the

diet mechanism, which can actually change how ketones are produced - and yes,

that would be reflected in blood levels. That doesn't mean the valproate would

falsely alter the blood ketone reading because of its excretion process as it

seems to with urine readings though, that means that the valproate can change

what level of ketosis the child is in fullstop, I would think?

Personally speaking, I just wanna get rid of the stuff here.....We started

weaming a few days ago, so I guess I will soon find out what effect it is gonna

have on 's ketones, haven't got any blood strips at the mo, but I am

intending to get some this week to keep an eye on things. Watch this space -

gulp.

----- Original Message -----

From: Bill Barber

,

Sorry, I am not convinced. I would have to see some stronger

information. Call me a cynic.

Bill

& Hill wrote:

> Depakote (valproate) is partially eliminated in the urine as a keto

metabolite, this is why it can give false positives in urine ketone readings.

So in our kiddies who are already producing urine ketones, the valproate can

make it appear that the kiddie is in deeper ketosis than we actually think.

> As it is just the metabolism of the med, and subsequent excretion in the

urine affected, as far as I am aware, this means that blood ketone (bhb)

readings are not affected.

>

>

[Guest guest]

Good luck.

Bill

& Hill wrote:

> Lol, well being slightly (actually make that very) cynical meself on

anything relating to these AEDs, I can relate to that.....

>

> 2 diff issues really though - one is how the valproate is metabolised,

broken down and then excreted - that is the issue was told about and was

querying - like can this excretion process alter what we see as a urine ketone

reading, leading to possible inaccuracy concerning what is going on in the

bloodstream, which is after all what is reflected in the brain...

> The other issue is how valproate itself interacts and/or 'competes' with the

diet mechanism, which can actually change how ketones are produced - and yes,

that would be reflected in blood levels. That doesn't mean the valproate would

falsely alter the blood ketone reading because of its excretion process as it

seems to with urine readings though, that means that the valproate can change

what level of ketosis the child is in fullstop, I would think?

> Personally speaking, I just wanna get rid of the stuff here.....We started

weaming a few days ago, so I guess I will soon find out what effect it is gonna

have on 's ketones, haven't got any blood strips at the mo, but I am

intending to get some this week to keep an eye on things. Watch this space -

gulp.

>

>

>

>

[Guest guest]

Thanx

----- Original Message -----

From: Bill Barber

Good luck.

Bill

& Hill wrote:

> Lol, well being slightly (actually make that very) cynical meself on

anything relating to these AEDs, I can relate to that.....

>

> 2 diff issues really though - one is how the valproate is metabolised,

broken down and then excreted - that is the issue was told about and was

querying - like can this excretion process alter what we see as a urine ketone

reading, leading to possible inaccuracy concerning what is going on in the

bloodstream, which is after all what is reflected in the brain...

> The other issue is how valproate itself interacts and/or 'competes' with

the diet mechanism, which can actually change how ketones are produced - and

yes, that would be reflected in blood levels. That doesn't mean the valproate

would falsely alter the blood ketone reading because of its excretion process as

it seems to with urine readings though, that means that the valproate can change

what level of ketosis the child is in fullstop, I would think?

> Personally speaking, I just wanna get rid of the stuff here.....We

started weaming a few days ago, so I guess I will soon find out what effect it

is gonna have on 's ketones, haven't got any blood strips at the mo, but I

am intending to get some this week to keep an eye on things. Watch this space -

gulp.

>

>

[Guest guest]

We've dropped down to 3 depakotes (2 in the pm) one in the am. This is the

third time we've attempted to wean it, and we're going very very slowly. ,

call/e-mail me.