Re: recurrence after tx.

[Guest guest]

Prof. Neuberger's figure of 60% PSC recurrence after tx has been mentioned before. He's a leading British hep and works in one of our largest liver units. But no other liver units report such a high figure. It's usually around 20-30%. On the other hand his figure for recurrence of PBC post-tx is unusually low and I don't think has been repeated elsewhere.

Why doesn't somebody in the group directly contact some of America's leading liver units and ask some heps who know us and with whom we've had contact, what the PSC recurrence rate is in their clinics. Someone like Prof. Shaw-Stiffel, (Med. Director of Liv Tx at UPMC), who's always very helpful to us.

Barb is still of the opinion that over 90% of us will need a tx. I've said before that that isn't our experience here in the UK. Neither within our group of 400 (and I know that's not hard evidence), but nor from the answers I get from some of our heps. The figure is more like one third.

Our newsletter, "PSC News" was posted yesterday and I hope subscribers amongst you will get it before Christmas.

Meanwhile from all of us to all of you - Have a merry Christmas and all the very best for 2007.

Ivor

[Guest guest]

I wonder if this difference is the same one that comes up in Prof.

Neuberger's study - i.e. if there are different ways of defining PSC in

the U.K. and in the U.S. (or in Prof. Neuberger's clinic and

elsewhere), might there be something in that difference that is

predictive of whether a transplant will be needed? Is there a way to

figure out what the specific parameters are that differentiate Prof.

Neuberger and other physicians' diagnoses? tx,

nina

> Barb is still of the opinion that over 90% of us will need a tx. I've

said

> before that that isn't our experience here in the UK. Neither within

our group

> of 400 (and I know that's not hard evidence), but nor from the

answers I get

> from some of our heps. The figure is more like one third.