rPSC question/answer from Neuberger

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-----Original

Message-----

From: Barb Henshaw [mailto:barbhenshaw (AT) peoplescom (DOT) net]

Sent: 16 December 2006 17:58

To: j.m.neuberger

Subject: rPSC question

Hello Dr Neuberger,

We have an on-line PSC Support group, with over 1200

members, from all over the world. Our current

discussion centers on recurrence of PSC after transplant. Looking at many different studies, we

find a very large disparity in rates of recurrence. It is thought to be anywhere from 10% to

your most recent study that quotes 60%.

Could you please share with us your thoughts on recurrence, the true

rate of recurrence and if possible why such a disparity?

Thank you very much,

Barb Henshaw PSC-Support group member.

Yantis, Texas

RE: rPSC question

Thanks.

I think the main reason lies in that different centres use different criteria

to define recurrent disease and the reported prevalence will vary as to how hard you look for it. I suspect these are the main reasons why there is

such a variation in the reported incidence.

I

Hope this is helpful.

Best

wishes