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Oncology help, please

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Oh, boy, it's my second favorite dictator -- an ESL who puts an " um "

sound at the end of almost every word.

I feel like I know the word that should fill in the blank below, but

it's eluding me this morning. There MAY be an " uh " sound as the first

syllable, before the " doe-stent " sounds, but it's heard to tell, because she

mutters so many " uh " and " um " sounds along the way.

This is a 37-year-old white female with a history of stage II breast

carcinoma, status post mastectomy, who is on ________ [sounds like

doe-stent] chemotherapy with adriamycin and Cytoxan.

I've listened over and over to try to hear " adjuvant " but that's not

it.

Any help sincerely appreciated.

Jayni

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Jayni:

This is just a guess, but could you be hearing " Zofran " ? From the QLEDB

2003:

ondansetron

U.S./Canadian Brand Names

Zofran® ODT [uS/Can]

Zofran® [uS/Can]

Therapeutic Category

Selective 5-HT3 Receptor Antagonist

Use

Prevention of nausea and vomiting associated with initial and repeat courses

of emetogenic cancer chemotherapy and prevention of postoperative nausea and

vomiting; prevent postoperative nausea/vomiting (I.M.)

Usual Dosage

Oral:

Children 4-11 years: 4 mg 30 minutes before chemotherapy; repeat 4 and 8

hours after initial dose

Children >11 years and Adults: 8 mg 30 minutes before chemotherapy; repeat

4 and 8 hours after initial dose or every 8 hours for a maximum of 48 hours

I.V.: Administer either three 0.15 mg/kg doses or a single 32 mg dose; with

the 3-dose regimen, the initial dose is given 30 minutes prior to

chemotherapy with subsequent doses administered 4 and 8 hours after the

first dose. With the single-dose regimen 32 mg is infused over 15 minutes

beginning 30 minutes before the start of emetogenic chemotherapy. Dosage

should be calculated based on weight:

Children: Pediatric dosing should follow the manufacturer's guidelines for

0.15 mg/kg/dose administered 30 minutes prior to chemotherapy, 4 and 8 hours

after the first dose. While not as yet FDA-approved, literature supports the

day's total dose administered as a single dose 30 minutes prior to

chemotherapy. Adults:

>80 kg: 12 mg IVPB

45-80 kg: 8 mg IVPB

<45 kg: 0.15 mg/kg/dose IVPB

Dosage Forms

Injection, solution, as hydrochloride (Zofran®): 2 mg/mL (2 mL, 20 mL)

Infusion, as hydrochloride [premixed in D5W] (Zofran®): 32 mg (50 mL)

Solution, as hydrochloride (Zofran®): 4 mg/5 mL (50 mL) [contains sodium

benzoate; strawberry flavor]

Tablet, as hydrochloride (Zofran®): 4 mg, 8 mg, 24 mg

Tablet, orally-disintegrating (Zofran® ODT): 4 mg, 8 mg [each strength

contains phenylalanine <0.03 mg/tablet; strawberry flavor]

Copyright 2003 by Lippincott & Wilkins

*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*

Karla Hilbourn, 47/VA

I.C., Family Practice, 2½ years

www.karlascozycorner.homestead.com

" Raising teenagers is like nailing Jello to a tree. "

*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*~*

>

>Reply-To: NMTC

>To: " NMTC " <nmtc >

>Subject: Oncology help, please

>Date: Wed, 20 Aug 2003 06:40:17 -0500

>

> Oh, boy, it's my second favorite dictator -- an ESL who puts an " um "

>sound at the end of almost every word.

>

> I feel like I know the word that should fill in the blank below, but

>it's eluding me this morning. There MAY be an " uh " sound as the first

>syllable, before the " doe-stent " sounds, but it's heard to tell, because

>she

>mutters so many " uh " and " um " sounds along the way.

>

> This is a 37-year-old white female with a history of stage II breast

>carcinoma, status post mastectomy, who is on ________ [sounds like

>doe-stent] chemotherapy with adriamycin and Cytoxan.

>

> I've listened over and over to try to hear " adjuvant " but that's not

>it.

>

> Any help sincerely appreciated.

>

> Jayni

>

>

> This e-mail has been scanned

> with Norton Antivirus that has

> been updated no longer than

> 24 hours ago. Have you updated

> your virus definitions today? ;-)

>

>

>

>____________________________________________________

> IncrediMail - Email has finally evolved - Click Here

>

>

>

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I don't know if this is what you are needing, but I found DepoCyt. I

didn't really understand this but thought it might give you a direction.

Below is a little bit of what I found. HYPERLINK

" http://www.ctclconsult.com/Clinical%20Oncology/022000/coa02012000e.htm "

http://www.ctclconsult.com/Clinical%20Oncology/022000/coa02012000e.htm

Best of luck!

Debi

Student

Synopsis: A sustained release formulation of cytarabine (DepoCyt) has

been shown to maintain cytotoxic drug concentration in the CSF for more

than 14 days after a single 50 mg injection.

Source: Glantz MJ, et al. Clin Cancer Res 1999; 5:3394-3402.

Carcinomatous meningitis can occur in approximately 5-8% of patients

with advanced solid tumors. Primary solid tumors that have been

associated with this disease process include breast cancer, lung cancer,

and melanoma.

Oncology help, please

Oh, boy, it's my second favorite dictator -- an ESL who puts an

" um "

sound at the end of almost every word.

I feel like I know the word that should fill in the blank below,

but

it's eluding me this morning. There MAY be an " uh " sound as the first

syllable, before the " doe-stent " sounds, but it's heard to tell, because

she

mutters so many " uh " and " um " sounds along the way.

This is a 37-year-old white female with a history of stage II

breast

carcinoma, status post mastectomy, who is on ________ [sounds like

doe-stent] chemotherapy with adriamycin and Cytoxan.

I've listened over and over to try to hear " adjuvant " but that's

not

it.

Any help sincerely appreciated.

Jayni

---

Outgoing mail is certified Virus Free.

Checked by AVG anti-virus system (http://www.grisoft.com).

Version: 6.0.512 / Virus Database: 309 - Release Date: 8/19/2003

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Thanks, Karl. As a matter of fact, Zofran was featured elsewhere in the

report, but I'm pretty certain that's not what I was hearing at the blank.

I've turned in the report now, and this one was much worse than her usual

dictation, so it had several blanks.

I'll let the list know if/when I find out what she was saying.

Jayni

> Oncology help, please

> >Date: Wed, 20 Aug 2003 06:40:17 -0500

> >

> > Oh, boy, it's my second favorite dictator -- an ESL who

> puts an " um "

> >sound at the end of almost every word.

> >

> > I feel like I know the word that should fill in the blank

> below, but

> >it's eluding me this morning. There MAY be an " uh " sound as the first

> >syllable, before the " doe-stent " sounds, but it's heard to tell, because

> >she

> >mutters so many " uh " and " um " sounds along the way.

> >

> > This is a 37-year-old white female with a history of

> stage II breast

> >carcinoma, status post mastectomy, who is on ________ [sounds like

> >doe-stent] chemotherapy with adriamycin and Cytoxan.

> >

> > I've listened over and over to try to hear " adjuvant " but

> that's not

> >it.

> >

> > Any help sincerely appreciated.

> >

> > Jayni

> >

> >

> > This e-mail has been scanned

> > with Norton Antivirus that has

> > been updated no longer than

> > 24 hours ago. Have you updated

> > your virus definitions today? ;-)

> >

> >

> >

> >____________________________________________________

> > IncrediMail - Email has finally evolved - Click Here

> >

> >

> >

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Thanks, Debi. I'm not sure, but the report has now gone to QA for

completion of multiple blanks. I'll report if/when I find out what she was

saying.

Jayni

Oncology help, please

Oh, boy, it's my second favorite dictator -- an ESL who puts an

" um "

sound at the end of almost every word.

I feel like I know the word that should fill in the blank below,

but

it's eluding me this morning. There MAY be an " uh " sound as the first

syllable, before the " doe-stent " sounds, but it's heard to tell, because

she

mutters so many " uh " and " um " sounds along the way.

This is a 37-year-old white female with a history of stage II

breast

carcinoma, status post mastectomy, who is on ________ [sounds like

doe-stent] chemotherapy with adriamycin and Cytoxan.

I've listened over and over to try to hear " adjuvant " but that's

not

it.

Any help sincerely appreciated.

Jayni

---

Outgoing mail is certified Virus Free.

Checked by AVG anti-virus system (http://www.grisoft.com).

Version: 6.0.512 / Virus Database: 309 - Release Date: 8/19/2003

Link to comment
Share on other sites

Thanks for letting me know Jayni. I really like hearing what things end

up being. Hope you are having a great day today!

Debi

Oncology help, please

Oh, boy, it's my second favorite dictator -- an ESL who puts an

" um "

sound at the end of almost every word.

I feel like I know the word that should fill in the blank below,

but

it's eluding me this morning. There MAY be an " uh " sound as the first

syllable, before the " doe-stent " sounds, but it's heard to tell,

because

she

mutters so many " uh " and " um " sounds along the way.

This is a 37-year-old white female with a history of stage II

breast

carcinoma, status post mastectomy, who is on ________ [sounds like

doe-stent] chemotherapy with adriamycin and Cytoxan.

I've listened over and over to try to hear " adjuvant " but that's

not

it.

Any help sincerely appreciated.

Jayni

---

Outgoing mail is certified Virus Free.

Checked by AVG anti-virus system (http://www.grisoft.com).

Version: 6.0.512 / Virus Database: 309 - Release Date: 8/19/2003

Link to comment
Share on other sites

Jayni,

I know this is too late, but could it have been dose-dense chemotherapy. I hear

that a lot with my PT (heme/onc) and also with my national

Do let us know.

Gai

Oncology help, please

Oh, boy, it's my second favorite dictator -- an ESL who puts an " um "

sound at the end of almost every word.

I feel like I know the word that should fill in the blank below, but

it's eluding me this morning. There MAY be an " uh " sound as the first

syllable, before the " doe-stent " sounds, but it's heard to tell, because she

mutters so many " uh " and " um " sounds along the way.

This is a 37-year-old white female with a history of stage II breast

carcinoma, status post mastectomy, who is on ________ [sounds like

doe-stent] chemotherapy with adriamycin and Cytoxan.

I've listened over and over to try to hear " adjuvant " but that's not

it.

Any help sincerely appreciated.

Jayni

This e-mail has been scanned

with Norton Antivirus that has

been updated no longer than

24 hours ago. Have you updated

your virus definitions today? ;-)

____________________________________________________

IncrediMail - Email has finally evolved - Click Here

Link to comment
Share on other sites

Yes, it WAS dose-dense. I just got the answer from QA. It was a new one

for me!

Jayni

Re: Oncology help, please

Jayni,

I know this is too late, but could it have been dose-dense chemotherapy.

I hear that a lot with my PT (heme/onc) and also with my national

Do let us know.

Gai

Oncology help, please

Oh, boy, it's my second favorite dictator -- an ESL who puts an

" um "

sound at the end of almost every word.

I feel like I know the word that should fill in the blank below,

but

it's eluding me this morning. There MAY be an " uh " sound as the first

syllable, before the " doe-stent " sounds, but it's heard to tell, because

she

mutters so many " uh " and " um " sounds along the way.

This is a 37-year-old white female with a history of stage II

breast

carcinoma, status post mastectomy, who is on ________ [sounds like

doe-stent] chemotherapy with adriamycin and Cytoxan.

I've listened over and over to try to hear " adjuvant " but that's

not

it.

Any help sincerely appreciated.

Jayni

This e-mail has been scanned

with Norton Antivirus that has

been updated no longer than

24 hours ago. Have you updated

your virus definitions today? ;-)

____________________________________________________

IncrediMail - Email has finally evolved - Click Here

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