Re: Important message you all want to read...and share

August 23, 2006

What awesome news! Congrats, . I'm gonna try the vitamin E!

>

> I am posting this for Dr. who is an amazing member of

> this group, who has news to share of her own son's rapid recovery

> from apraxia. As Marina just stated the following methods -as

> incredible as they are -are combined with appropriate and

> traditional speech and occupational therapies. As a wise neuroMD

> once told us as the first apraxia conference

> " the brain responds to multiple stimuli "

> http://www.cherab.org/news/scientific.html

>

> Please read the following and share with your child's

> pediatrician...this is cutting edge information to help your child

> now. Nobody knows where these previously rare multifaceted

conditions like

> apraxia are coming from in alarming rising numbers -but perhaps as a

group we

> can learn how to help our children today. Or you can wait for the

> studies that are planned. You'll be able to read about them here

> too.... in years.

>

> I know that " " doesn't always share who she is -we just know

> her here as , but she is not 'just' , and not 'just' a

> Mom, is also a highly respected pediatrician and researcher -

> (as well as being a parent of a child with apraxia)

>

> You may see this message more than once - posted it too...but

> I wanted to send this out as a special announcement to make sure all

> receive this information. Nobody here will be able to say " why

> didn't you tell me?!! " Please share this with others who may need

> to know too. And please share here what you find -like .

>

> Thank you for sharing -ironically, words can't express my

> pride and happiness for ph and all those like him! Three cheers

> for you too Dr. -you put the " Dr. Mom " in Dr. Mom!

>

> From: " " <claudiamorris@...> A

> "

August 23, 2006

,

How absolutely amazing that you found another big key to curing your

son! I'm so happy for you, and thank you for sharing with the rest

of us. Coincidentally, I just started learning about the great

benefits of Vit E supplementation for adults, and started taking

about 800 IU per day. I will most definitely start Meg on 400 IU,

and I'll be sure to post if I see big results. I learned that the

RDA for Vitamin E is intended only for prevention of deficiency, and

not as a recommendation for general health. And I was always so

concerned about getting too much!

I often wondered if Vitamin E was part of the reason that fish oils

and Carnaware are so effective. Hopefully we'll get some more

parents trying it and reporting results soon.

Kerri

>

> I am posting this for Dr. who is an amazing member

of

> this group, who has news to share of her own son's rapid recovery

> from apraxia. As Marina just stated the following methods -as

> incredible as they are -are combined with appropriate and

> traditional speech and occupational therapies. As a wise neuroMD

> once told us as the first apraxia conference

> " the brain responds to multiple stimuli "

> http://www.cherab.org/news/scientific.html

>

> Please read the following and share with your child's

> pediatrician...this is cutting edge information to help your child

> now. Nobody knows where these previously rare multifaceted

conditions like

> apraxia are coming from in alarming rising numbers -but perhaps as

a group we

> can learn how to help our children today. Or you can wait for the

> studies that are planned. You'll be able to read about them here

> too.... in years.

>

> I know that " " doesn't always share who she is -we just know

> her here as , but she is not 'just' , and not 'just'

a

> Mom, is also a highly respected pediatrician and

researcher -

> (as well as being a parent of a child with apraxia)

>

> You may see this message more than once - posted it

too...but

> I wanted to send this out as a special announcement to make sure

all

> receive this information. Nobody here will be able to say " why

> didn't you tell me?!! " Please share this with others who may need

> to know too. And please share here what you find -like .

>

> Thank you for sharing -ironically, words can't express my

> pride and happiness for ph and all those like him! Three

cheers

> for you too Dr. -you put the " Dr. Mom " in Dr. Mom!

>

> From: " " <claudiamorris@...> A

> "

August 23, 2006

,, and everyone.

That is VERY interesting, and VERY inspiring to hear about ph.

It makes me want to try Vit. E supplement with my daughter.

I too did a little reading about the signs/symptoms related to vit e

deficiency. It turns out (according to Merck) Abby has had most of

them too. (including ophthalmoplegia) If you recall I once posted how

her eyes made very fast jerky movements. She did this 2x in the

hospital as a newborn, then again shortly after coming home. When I

told her pediatrician, he claimed to examine her, and I quote " there

doesn't seem to be anything wrong "

While reading the signs/symptoms, I continued to look up the Vitamin

E information. One of the pages I read was from the Hopkins

Medicine webpage.

/post?act=reply & messageN\

um=50746

They claim to have done a study on vitamin E supplentation. And their

conclusion is high doses, (Over 400 IU) may have a higher overall

risk of dying. They go on to say most of the people in their study

are over age 60, and not all were in perfect health.

I only bring this up, because it does concern me, that in effort to

help, we " might " inadvertantly hurt our children. With your medical

expertise, maybe you can shed some light on this issue/study.

Please do not take my questions the wrong way. I am certainly not

trying to disprove your claim, nor am I trying to persuade anyone

from NOT trying a new option to help our children. I just want

reassurance.

Thank you..

Dawn in NJ

In , " kiddietalk "

<kiddietalk@...> wrote:

>

> I am posting this for Dr. who is an amazing member of

> this group, who has news to share of her own son's rapid recovery

> from apraxia. As Marina just stated the following methods -as

> incredible as they are -are combined with appropriate and

> traditional speech and occupational therapies. As a wise neuroMD

> once told us as the first apraxia conference

> " the brain responds to multiple stimuli "

> http://www.cherab.org/news/scientific.html

>

> Please read the following and share with your child's

> pediatrician...this is cutting edge information to help your child

> now. Nobody knows where these previously rare multifaceted

conditions like

> apraxia are coming from in alarming rising numbers -but perhaps as

a group we

> can learn how to help our children today. Or you can wait for the

> studies that are planned. You'll be able to read about them here

> too.... in years.

>

> I know that " " doesn't always share who she is -we just know

> her here as , but she is not 'just' , and not 'just' a

> Mom, is also a highly respected pediatrician and

researcher -

> (as well as being a parent of a child with apraxia)

>

> You may see this message more than once - posted it too...but

> I wanted to send this out as a special announcement to make sure all

> receive this information. Nobody here will be able to say " why

> didn't you tell me?!! " Please share this with others who may need

> to know too. And please share here what you find -like .

>

> Thank you for sharing -ironically, words can't express my

> pride and happiness for ph and all those like him! Three cheers

> for you too Dr. -you put the " Dr. Mom " in Dr. Mom!

>

> From: " " <claudiamorris@...> A

> "

August 23, 2006

,

Wonderful news on your detective work. We also had the same here,

ADEK were all in the low normal, when we supplemented those, we also

lost the apraxia/hypotonia/SID within about a months time, although

the levels did not reflect the huge improvements we obtained, you are

fortunate you discovered this at such an early age. We found it at

the age of 5,(my son is now 8, our story is in the archieves) and we

had for who knows how long, fat soluble vitamin deficiencies that

bone growth was affected, mild ricketts/osteoporosis that is now

resolved. You might want to get his D and K levels checked. Although,

levels test low norm, not much attention is ever given to it. When we

supplemented vitamin K, we sustained huge surges cognitively. Here is

an article on Vitamin K and oxidative stress in developing neurons if

you have not seen it yet. L-Carnitine is used extensively in children

with autism and should be with apraxia as well if the testing

justifies it. In my practice nearly all the kids are on A,D,E,K,

carnitine etc. When we supplemented my son appropriately, his

allergies were eliminated completely, same goes for most of the kids

we work with.

J Neurosci. 2003 Jul 2;23(13):5816-26. Links

Novel role of vitamin k in preventing oxidative injury to developing

oligodendrocytes and neurons.

Li J,

Lin JC,

Wang H,

JW,

Furie BC,

Furie B,

Booth SL,

Volpe JJ,

Rosenberg PA.

Department of Neurology, Division of Neuroscience, Children's

Hospital, Boston, MA 02115, USA.

Oxidative stress is believed to be the cause of cell death in

multiple disorders of the brain, including perinatal

hypoxia/ischemia. Glutamate, cystine deprivation, homocysteic acid,

and the glutathione synthesis inhibitor buthionine sulfoximine all

cause oxidative injury to immature neurons and oligodendrocytes by

depleting intracellular glutathione. Although vitamin K is not a

classical antioxidant, we report here the novel finding that vitamin

K1 and K2 (menaquinone-4) potently inhibit glutathione depletion-

mediated oxidative cell death in primary cultures of oligodendrocyte

precursors and immature fetal cortical neurons with EC50 values of

30 nm and 2 nm, respectively. The mechanism by which vitamin K

blocks oxidative injury is independent of its only known biological

function as a cofactor for gamma-glutamylcarboxylase, an enzyme

responsible for posttranslational modification of specific proteins.

Neither oligodendrocytes nor neurons possess significant vitamin K-

dependent carboxylase or epoxidase activity. Furthermore, the

vitamin K antagonists warfarin and dicoumarol and the direct

carboxylase inhibitor 2-chloro-vitamin K1 have no effect on the

protective function of vitamin K against oxidative injury. Vitamin K

does not prevent the depletion of intracellular glutathione caused

by cystine deprivation but completely blocks free radical

accumulation and cell death. The protective and potent efficacy of

this naturally occurring vitamin, with no established clinical side

effects, suggests a potential therapeutic application in preventing

oxidative damage to undifferentiated oligodendrocytes in perinatal

hypoxic/ischemic brain injury.

PMID: 12843286 [PubMed - indexed for MEDLINE

> >

> > I am posting this for Dr. who is an amazing member

> of

> > this group, who has news to share of her own son's rapid recovery

> > from apraxia. As Marina just stated the following methods -as

> > incredible as they are -are combined with appropriate and

> > traditional speech and occupational therapies. As a wise neuroMD

> > once told us as the first apraxia conference

> > " the brain responds to multiple stimuli "

> > http://www.cherab.org/news/scientific.html

> >

> > Please read the following and share with your child's

> > pediatrician...this is cutting edge information to help your child

> > now. Nobody knows where these previously rare multifaceted

> conditions like

> > apraxia are coming from in alarming rising numbers -but perhaps

as

> a group we

> > can learn how to help our children today. Or you can wait for the

> > studies that are planned. You'll be able to read about them here

> > too.... in years.

> >

> > I know that " " doesn't always share who she is -we just

know

> > her here as , but she is not 'just' , and

not 'just'

> a

> > Mom, is also a highly respected pediatrician and

> researcher -

> > (as well as being a parent of a child with apraxia)

> >

> > You may see this message more than once - posted it

> too...but

> > I wanted to send this out as a special announcement to make sure

> all

> > receive this information. Nobody here will be able to say " why

> > didn't you tell me?!! " Please share this with others who may need

> > to know too. And please share here what you find -like .

> >

> > Thank you for sharing -ironically, words can't express my

> > pride and happiness for ph and all those like him! Three

> cheers

> > for you too Dr. -you put the " Dr. Mom " in Dr. Mom!

> >

> > From: " " <claudiamorris@> A

> > "

August 23, 2006

Some interesting comments on the Hopkins study you are asking about are

attached below. Some studies can be very misleading, especially depending

upon how the statistics are run. But this is the sort of story that makes

headlines. My crazy experience with the media...I published an asthma study

in 2004 that demonstrated that arginine levels (an amino acid in nuts and

peanutbutter) are low in acute asthma. The newspapers tried to get me to say

that peanutbutter would treat asthma...that WAS NOT my conclusion, nor would

I say that (although I would love it if SKIPPY wants to fund my studies -

but again, what makes news is often far from the truth). The newsclip intro

to the local TV news broadcast was that " Oakland researcher finds a cure for

asthma " , while showing pictures of the local grocery store peanutbutter

isle. OK, I wanted to hide, but had to follow that intro and try to redirect

them. My kids thought it was cool regardless.

Also, ONLY one vitamin E study showed statistically increased risk of death

(as opposed to the other 13 studies demonstrating benefits). It was a

meta-analysis, or a statistical sum of all the studies, so misleading. In

addition, the methods and doses used in each individual study was

different - as were the type of patients involved in each of the 14 studies.

Many patients were on other vitamin supplements, so impossible to tell what

effect was from what, and most of the patients were using synthetic vs.

natural vitamin E. There is a difference between synthetic and natural, and

the synthetic E may deplete or impact natural vit E effects. Also if our

apraxic kids end up having an increased consumption/utilization of vitamin

E, decreased absorption or abnormal metabolism of vitamin E...any mechanism

that may increase the body's need for vitamin E - these kids would be in a

different catagory than the normal person on the street without a

deficiency. Give a bolus of insulin to a non-diabetic, and you may kill

them. However insulin is life saving for those whose body can't make it.

Not to say vitamin E is like insulin, but in a way...I did tell my

pediatrician after one of ph's regressions off fish oil, that I felt

like it was in fact his " insulin " , and without it...his brain just fell

apart.

See below for a commentary written about the Hopkins report. It may clarify

things. Regardless, a dose of 400 IU a day is benign for a child...but it

should be NATURAL, not synthetic. The label should read " alpha-d-tocophorol "

and NOT alpha-dl-tocophorol. Its the " dl " that tells you its synthetic, but

easy to miss this small differentiation. In addition, gamma tocophorol

should be used...and it comes in 200-300 mg gel caps. One alpha and one

gamma a day is a good safe dose...until we know more. But this is why it may

make sense to check vitamin E plasma levels first, since a documented

vitamin E deficiency may suggest the need for even higher doses. To give

you an idea, the recommended dose for vitamin E deficiency related

neuropathy, or nerve/brain damage (???which some of our apraxic kids may

just have???) is 100 mg/kg/day (or 140 IU/kg/d). This is a VERY high dose,

and is indicated for Vit E deficiency syndromes, and something that should

be monitored closely by an MD or nutritionalist. But this dose is indicated

for certain disease states of deficiency, and essential to these particular

patients in order to treat their condition. For apraxia - we don't know if

there is a deficiency that can be identified by a blood test, or if patients

need higher than normal levels to fix neurological symptoms for some other

reason. All I know is that omega 3 worked wonders in helping my son

progress with aggressive ST and OT. Yet Vitamin E is causing/has caused a

resolution of ALL symptoms of global apraxia/hypotonia and SID. My son also

has been identified recently with a severe carnitine deficiency. This is not

routinely checked in apraxia. Maybe is should be. This may be uncommon -

however to have this undiagnosed and untreated can lead to sudden death.

Scary. We are getting all my kids checked for low carnitine, in case it is

some genetic red herring totally unrelated to apraxia. However since it is

commonly reported in children with autism, I suspect this may not be that

rare. One never knows until one really looks. Although Vitamin E is an

unlikely culprit, sometimes the most complicated problems still have a

simple answer.

Unfortunately the sensationalism of headline news may scare people away from

potentially good treatments. Just like the fear of fish oil. I think it is

good to ask questions though, and not take the " unknown " at face value. So I

don't take your question the wrong way. It is actually an excellent

question, since it is so hard to sift through the literature and figure out

what is and isn't valid. It is also possible that what we are experiencing

with my boy is a fluke from some weird genetics specific to my son. But

since he sounds like the posterchild for global apraxia, I don't think this

will be an isolated observation, particularly in kids who respond to omega

supplements. Without my own relentless " why " - my son would still be

severely impaired. -

----------------------------------------------------------------------------

----------------------------------

The real facts about the vitamin E death warning...

Print Report | Add to Favorites

Do you ever feel fed up with all the conflicting health information in

newspapers and magazines?

This week, you'll see a story about the benefits of taking a certain

supplement. A week later, you'll read or hear a report about the dangers of

the very same substance, with warnings by an expert to stay away from it.

A good example comes from the latest " death warning " about vitamin E.

According to recent headlines, people could be " risking their lives " if they

take even moderately high doses of vitamin E [1].

To add to the confusion, researchers from Israel now tell us that some

patients with diabetes can reduce their risk of dying from heart disease by

taking — you guessed it — high doses of vitamin E [2].

This kind of conflicting evidence prompts many frustrated people to throw up

their arms in frustration at the fact that " even the experts can't agree. "

It's easy to become so frustrated and confused that you simply ignore it

all.

Don't throw your vitamin E supplements in the bin just yet. There are

several important aspects of the s Hopkins study that didn't get much

coverage in the news.

Here's a closer look at what they actually did.

The researchers looked at a number of studies carried out between 1993 and

2004. All compared vitamin use against a dummy supplement (placebo).

They found that the risk of death did not differ significantly between

people given vitamin E and those assigned to placebo.

However, the effect of vitamin E differed according to how much was used. In

the low-dose studies, vitamin E was linked with a small reduction in the

death rate.

In the high-dose studies, those who took vitamin E had a 4% increase in the

risk of death. Though this increase was small, it was statistically

significant.

It was this discovery that generated the headlines.

One problem is that the review included studies where vitamin E was taken

with other vitamins and minerals. The increased risk of death found in some

of the studies could have been linked with these other nutrients. It may

have had nothing to do with vitamin E.

What's more, many of the study groups were people with pre-existing chronic

diseases such as cancer, heart disease, Alzheimer's, Parkinson's and kidney

failure.

Even the editors of the ls of Internal Medicine (the journal where the

study was published) write that the findings may not apply to healthy

adults.

Dr. Alan Gaby, an expert in nutritional therapies, also points out that some

of the results were complicated by the fact that the vitamin E and placebo

groups were not comparable.

" In one high-dose vitamin E study (Cambridge Heart Antioxidant Study), the

vitamin E group had higher cholesterol levels and significantly greater

percentages of participants with high blood pressure, diabetes, cigarette

smoking, and severe coronary artery disease, compared with the placebo

group, " says Dr. Gaby.

" Thus, the people taking vitamin E were sicker than those taking the

placebo, a fact that could account for the slight increase in mortality seen

in the vitamin E group. "

Facts about vitamin E

There are also several different forms of vitamin E. Read the label on a

vitamin E supplement, and it will probably say alpha-tocopherol (pronounced

al-fa tocko-ferol).

Most of the studies reviewed in the s Hopkins research were done using

the synthetic (dl-alpha-tocopherol) rather than the natural

(d-alpha-tocopherol) form of alpha-tocopherol.

Natural vitamin E has roughly twice the availability of synthetic vitamin E.

Because of this, you have to take about twice as much of it to get the same

effect [4].

If there is a small negative effect of high-dose vitamin E, it might be due

in part to the use of dl-alpha-tocopherol.

Vitamin E is actually a collective term for eight naturally occurring

compounds, four tocopherols (alpha-, beta-, gamma- and delta-) and four

tocotrienols (alpha-, beta-, gamma- and delta-).

Concentrations of alpha-tocopherol are higher in wheat germ oil, almond and

sunflower oil; gamma-tocopherol is the major form of vitamin E in corn oil

and soybean oil; levels of tocotrienols are high in rice bran, barley, oats

and palm oil.

Although most research has focused on the potential health effects of

alpha-tocopherol, the three other tocopherols and four tocotrienols are also

important.

In fact, supplementing with alpha-tocopherol has been shown to reduce blood

levels of gamma- and delta-tocopherol [3].

Although they're usually more expensive than alpha-tocopherol, mixed

tocopherols are the preferable form of vitamin E, in terms of both safety

and effectiveness.

If you do use a high-dose vitamin E supplement, look for one that contains

mixed tocopherols. Some manufacturers use this term to mean the synthetic

dl-alpha-tocopherol, so you need to read the label closely.

Of course, the fact that some forms of vitamin E are natural doesn't mean it

can be consumed safely in unlimited amounts. Many supplements, including

vitamin C, iron, CLA and CoQ10 — under certain conditions — can have

negative side effects.

Even plain water has the potential to be harmful [6]!

Based on its blood-thinning effects, there are concerns that vitamin E could

cause problems if combined with medications that also thin the blood, such

as aspirin. In theory, the blood could thin too much, causing bleeding

problems.

Vitamin E may also enhance the body's sensitivity to its own insulin in

people with type II diabetes [5]. This could lead to a risk of blood sugar

levels falling too low.

If you're taking medication, it would be a good idea to talk with your

physician before using a high-dose vitamin E supplement.

The bottom line

One of the main goals of a newspaper or magazine is to sell more copies.

They'll achieve this with a sensational headline that reads something like

" vitamin E death warning " rather than one that accurately reflects the

findings of a study.

Personally, I use a multi-vitamin and mineral supplement that contains 150

IU of vitamin E (d-alpha-tocopherol succinate). Most days, I also use a meal

replacement supplement containing 30 IU of vitamin E. That gives me at least

180 IU of vitamin E each day, plus what I get from my diet.

This new research has not convinced me to use less vitamin E.

One study is not really news. Think of it as a single piece of a jigsaw

puzzle. It's only when you put the pieces together by comparing many studies

in a given field that you get an accurate picture of what's really going on.

Do you need help burning the fat from your belly or packing muscle on your

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References

1. , E.R. 3rd, Pastor-Barriuso, R., Dalal, D., Riemersma, R.A., Appel,

L.J., & Guallar, E. (2004). Meta-Analysis: High-Dosage Vitamin E

Supplementation May Increase All-Cause Mortality. ls of Internal

Medicine, 142

2. Levy, A.P., Gerstein, H.C., -Lotan, R., Ratner, R., McQueen, M.,

Lonn, E., & Pogue, J. (2004). The effect of vitamin E supplementation on

cardiovascular risk in diabetic individuals with different haptoglobin

phenotypes. Diabetes Care, 27, 2767

3. Huang, H.Y., & Appel, LJ. (2003). Supplementation of diets with

alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol

in humans. Journal of Nutrition, 133, 3137-3140

4. Burton, G.W., Traber, M.G., Acuff, R.V., Walters, D.N., Kayden, H.,

, L., & Ingold, K.U. (1998). Human plasma and tissue alpha-tocopherol

concentrations in response to supplementation with deuterated natural and

synthetic vitamin E. American Journal of Clinical Nutrition, 67, 669-684

5. Manning, P.J., Sutherland, W.H., , R.J., , S.M., De Jong,

S.A., Ryalls, A.R., & Berry, E.A. (2004). Effect of high-dose vitamin E on

insulin resistance and associated parameters in overweight subjects.

Diabetes Care, 27, 2166-2171

6. Noakes, T.D. (2003). Overconsumption of fluids by athletes. British

Medical Journal, 327, 113-114

[ ] Re: Important message you all want to

read...and share

,, and everyone.

That is VERY interesting, and VERY inspiring to hear about ph.

It makes me want to try Vit. E supplement with my daughter.

I too did a little reading about the signs/symptoms related to vit e

deficiency. It turns out (according to Merck) Abby has had most of

them too. (including ophthalmoplegia) If you recall I once posted how

her eyes made very fast jerky movements. She did this 2x in the

hospital as a newborn, then again shortly after coming home. When I

told her pediatrician, he claimed to examine her, and I quote " there

doesn't seem to be anything wrong "

While reading the signs/symptoms, I continued to look up the Vitamin

E information. One of the pages I read was from the Hopkins

Medicine webpage.

/post?act=reply & mess

ageNum=50746

They claim to have done a study on vitamin E supplentation. And their

conclusion is high doses, (Over 400 IU) may have a higher overall

risk of dying. They go on to say most of the people in their study

are over age 60, and not all were in perfect health.

I only bring this up, because it does concern me, that in effort to

help, we " might " inadvertantly hurt our children. With your medical

expertise, maybe you can shed some light on this issue/study.

Please do not take my questions the wrong way. I am certainly not

trying to disprove your claim, nor am I trying to persuade anyone

from NOT trying a new option to help our children. I just want

reassurance.

Thank you..

Dawn in NJ

In , " kiddietalk "

<kiddietalk@...> wrote:

>

> I am posting this for Dr. who is an amazing member of

> this group, who has news to share of her own son's rapid recovery

> from apraxia. As Marina just stated the following methods -as

> incredible as they are -are combined with appropriate and

> traditional speech and occupational therapies. As a wise neuroMD

> once told us as the first apraxia conference

> " the brain responds to multiple stimuli "

> http://www.cherab.org/news/scientific.html

>

> Please read the following and share with your child's

> pediatrician...this is cutting edge information to help your child

> now. Nobody knows where these previously rare multifaceted

conditions like

> apraxia are coming from in alarming rising numbers -but perhaps as

a group we

> can learn how to help our children today. Or you can wait for the

> studies that are planned. You'll be able to read about them here

> too.... in years.

>

> I know that " " doesn't always share who she is -we just know

> her here as , but she is not 'just' , and not 'just' a

> Mom, is also a highly respected pediatrician and

researcher -

> (as well as being a parent of a child with apraxia)

>

> You may see this message more than once - posted it too...but

> I wanted to send this out as a special announcement to make sure all

> receive this information. Nobody here will be able to say " why

> didn't you tell me?!! " Please share this with others who may need

> to know too. And please share here what you find -like .

>

> Thank you for sharing -ironically, words can't express my

> pride and happiness for ph and all those like him! Three cheers

> for you too Dr. -you put the " Dr. Mom " in Dr. Mom!

>

> From: " " <claudiamorris@...> A

> "

August 23, 2006

This is excellent. Thanks for sending. We are actually getting ADEK checked

with the next blood draw. I am worried about vit K since I suspect we will

find a low level and it is the one potential adverse effect of high dose vit

E - lower K and bleeding. I didn't know Vit K had any effects outside of

bleeding, so this really is good stuff. -