Thyroid Hormone RESISTANCE in the Heart

February 3, 2007

And it would also give a more than big clue as to how thyroid hormone works on a whole separate level in various parts of the body, one part accepting and processing thyroid hormone in a completely different rate and way from each other body part. Everywhere you see the intials "TR" in this doctors' study, it means "Thyroid Receptor(s)". I believe that the "RTH" in there means Resistant Thyroid Hormone Receptors or something like that. The Keys are probably there, I just didn't look. These studies like this one make me feel language impaired, lol. Anyway, this is a dominant genetic inheritance in some cases, and it is probably the reason or one of the reasons why a lot of folks lab results look good on paper, yet they still feel rotten. It may also be the reason why a lot of folks continue to have a slow heart rate or palpitations, even when their treatment LOOKS to be adequate, possibly even taking higher amts of thyroid hormones. I haven't read far enough in the links on the thyroid support site where I found this to see what would be the ongoing treatment for this, though I can suspect that it's probably going to be greater amts of T3, but that's just a guess on my part. When I found this, I was looking for more specific Hashimot's support, going through several group profiles, but the site I found this on appears to be very inactive since last October. Someone owns this site who used to be on one of the groups I've been on, but I haven't seen the id lately. Anyway, here is the link, if you can understand the language in there, lol.

http://ahavj.ahajournals.org/cgi/content/full/circresaha;86/6/700

February 3, 2007

Now that is tweaking at some of the stuff that I've been wondering about... getting into how some folks can take several Grain of Natural first thing in the morning and do fine all do and then poor pathetic me multi-dosing all through the day to keep going... Bits and pieces come through in stuff that I've read that conversion impairment can cause some folks to need T3 delivered throughout the day cuz their 'main' T3 receptors are not being kept filled with the body's conversion rate... that by multi-dosing the T3 those major/main areas are kept filled and then conversion is needed only to fill the 'peripheral' receptors, allowing there to be more extensive saturation.

In my case, I've always wondered that if I have bad TSH receptors on the gland.. do I also have some bad thyroid hormone receptors too? Is that why I need the T3 so spread out during the day?

I did an experiment the last couple of nights, just to confirm, or disprove, a test that I did on myself several years ago.

I held back my bedtime dose of thyroid, well, not held back.. took early... so that I was taking it about 45 minutes before bed instead of just before rolling over to go to sleep. It caused the back ribs to pain-up again. Enough so that it has been slightly uncomfortable to lean back in a chair, or even lay on my back in bed.

Last night I was the obedient victim and popped it under my tongue as I snuggled in to sleep.... See? Look... I can stretch my arms up to the ceiling, twist at the waist, reach sideways across the desk... no discomfort.

.... and I'm still at a very low dose (compared to my 'good' dose before running out) and the bulk of the thyroid that I'm taking right now is OTC grade through Nutri-meds. Just how messed up is my body, and why?

Why is it that taking synthetic T4 causes my tendons to go whonky?

Is it from the storm? From the genetic TSH receptor fault? From the years of inadequate/negligent care from the docs? Or... is it a receptor defect involving the T3 receptors on top of all the rest?

You've given me more stuff to read ... it won't 'fix' me.. but I'd sure like to understand the WHY in my having to be so diligent in how I'm dosing... right now, on this light dosing, I have to dose every two hours... If I forget and it gets toward that three hour mark I'm flopping face first on the keyboard asleep or yawning so big that my eyes water and my jaw cracks. It just starts with no warning. I'm not getting drowsy, I'm not getting the 'I'm sleepy I feel cold', it's more like a switch got flipped to 'OFF' and some things stop functioning in me...

I wish I could just jump up to my 'good' dose... but I know I'll have hyper surges and no telling what it will do to my heart.

So, patience, as I gradually work my dose back up and rebuild my stripped out T4 reserves and there is enough there again for conversion to fill in the gaps between dosing.....

Part of me thinks that this 'narcolepsy', for lack of a better term, is because my body still remembers that it's the T3 that it needs to function and is just sucking the stuff up as soon as I take it... and then there isn't enough raw material (stored T4) for conversion yet to carry it over.. that would be a good sign, right? That my body is still wanting/willing/able to function well and strong, just doesn't have enough hormone to go whole hog (ooooooo pun unintentional but acceptable!!) yet.

Topper ()

On Sat, 3 Feb 2007 05:28:06 -0600 " " writes:

And it would also give a more than big clue as to how thyroid hormone works on a whole separate level in various parts of the body, one part accepting and processing thyroid hormone in a completely different rate and way from each other body part. Everywhere you see the intials "TR" in this doctors' study, it means "Thyroid Receptor(s)". I believe that the "RTH" in there means Resistant Thyroid Hormone Receptors or something like that. The Keys are probably there, I just didn't look. These studies like this one make me feel language impaired, lol. Anyway, this is a dominant genetic inheritance in some cases, and it is probably the reason or one of the reasons why a lot of folks lab results look good on paper, yet they still feel rotten. It may also be the reason why a lot of folks continue to have a slow heart rate or palpitations, even when their treatment LOOKS to be adequate, possibly even taking higher amts of thyroid hormones. I haven't read far enough in the links on the thyroid support site where I found this to see what would be the ongoing treatment for this, though I can suspect that it's probably going to be greater amts of T3, but that's just a guess on my part. When I found this, I was looking for more specific Hashimot's support, going through several group profiles, but the site I found this on appears to be very inactive since last October. Someone owns this site who used to be on one of the groups I've been on, but I haven't seen the id lately. Anyway, here is the link, if you can understand the language in there, lol.

http://ahavj.ahajournals.org/cgi/content/full/circresaha;86/6/700

February 3, 2007

In this study, the main problem is that, while other areas of the body are converting and receiving this same amt of thyroid hormone, humming along and being healthy, the heart may still be VERY HYPOthyroid. In other words, in each individual, it may be virtually impossible for every single body part to be equally "fed" by the thyroid hormones. Let's say that a person is taking what is probably their optimal dose----Their brain fog is gone, their muscles feel great, they feel wide awake----But when they go UP in their dose to get rid of the palps, or, let's say, get rid of their dry skin, memory loss, etc.....(you get the picture)--------they get rid of the dry skin and some of this other stuff, or they get rid of the palps, and not the dry skin------------Then the hyper symptoms ensue with whatever types of hyper symptoms that THAT person is going to manifest---------It may not have anything to do with their adrenal function. What it may have to do with is the fact that each body part is using very separate amts of thyroid hormone, and on a fixed dose (like all of us), it may be virtually impossible for SOME of us to NOT have hyper symptoms, say, in the central nervous system, while another body part is STILL hypothyroid. This is what hits us all----that we have a chronic chronic disease, and that some of us may strike it lucky with a certain dose, but some of us may have ups and downs no matter what dose we're at. That is not the voice of doom and gloom, that is the reality of an autoimmune "incurable" disease, as it is defined. The article is saying that the receptors at one body part may be freaked out and others may be right in tune. How in the heck is that going to be handled? Flooding the receptors with T3? Yes, it seems like the only way, but, for some people, at what cost? This is why I am so conservative these days and won't give any advice on what each person should take, in the way of thyroid hormones, because of these vast differences, and this is, of course, coming from someone who IS self treating also, but I wouldn't advise that for just everybody. You've got to be so cautious about this and know exactly what you're doing, or you could get into all kinds of trouble. On another site, I can see how liberal they've gotten about this, advising "You should increase this", or "You should increase that", but they don't really know all about that particular person or their physical makeup. I've seen tiny people on 9 to 10 grains of Armour, and it's not even phasing them, but I've also seen rather large people that can't even get up to 1 grain of thyroid hormone or 2 grains or so, and their body is freaking out already. Up to this point, we've been calling this adrenal fatigue, and I think that MOST of the time, it is, but for those people who dont' have adrenal fatigue, this disregulated level of body receptor problems in one part of the body, but not in the other part, is going to be THEIR problem, and none of us know that yet, including the victim.

Re: Thyroid Hormone RESISTANCE in the Heart