Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 There was a recent discussion about physiology. Thus, here is a physiology conundrum. Why will there never be " oximetry " for carbon dioxide monitoring? Let's see who really knows the details. E. Bledsoe, DO, FACEP Midlothian, Texas Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 Hey you clearly need some sleep. Does your question refer to the binding mechanism of carbon dioxide or are you referring to our ability to measure carbon dioxide in the blood? Or none of the above, your question is a bit vague. Anxiously awaiting your response. Texas Puzzler There was a recent discussion about physiology. Thus, here is a physiology conundrum. Why will there never be " oximetry " for carbon dioxide monitoring? Let's see who really knows the details. E. Bledsoe, DO, FACEP Midlothian, Texas Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 Why will there never be oximetry for carbon dioxide like there is for oxygen (at least with currently available technology). If my question were too specific I would give away the answer. BEB _____ From: texasems-l [mailto:texasems-l ] On Behalf Of Sent: Monday, January 15, 2007 12:04 AM To: texasems-l Subject: RE: Texas Puzzler Hey you clearly need some sleep. Does your question refer to the binding mechanism of carbon dioxide or are you referring to our ability to measure carbon dioxide in the blood? Or none of the above, your question is a bit vague. Anxiously awaiting your response. Texas Puzzler There was a recent discussion about physiology. Thus, here is a physiology conundrum. Why will there never be " oximetry " for carbon dioxide monitoring? Let's see who really knows the details. E. Bledsoe, DO, FACEP Midlothian, Texas Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 Close: CO2: 70% as HCO3- 23% reversibly bound to hemoglobin 7% dissolved in plasma O2: 97% reversibly bound to hemoglobin 3% dissolved in plasma. Again, there is some CO2 bound to hemoglobin. Why can't oximetry detect this? _____ From: texasems-l [mailto:texasems-l ] On Behalf Of Sent: Monday, January 15, 2007 12:27 AM To: texasems-l Subject: RE: Texas Puzzler I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 Oxygen binds to the heme component of hemoglobin, CO2 binds to a different site on the hemoglobin (the N-Terminal groups on the 4 globin chains). JT RE: Texas Puzzler I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 I know. What does that mean? Where does CO bind? What happens to Hb when O2 binds? _____ From: texasems-l [mailto:texasems-l ] On Behalf Of Sent: Monday, January 15, 2007 12:45 AM To: texasems-l Subject: RE: Texas Puzzler Oxygen binds to the heme component of hemoglobin, CO2 binds to a different site on the hemoglobin (the N-Terminal groups on the 4 globin chains). JT RE: Texas Puzzler I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 CO? Have we just changed to carbon monoxide? CO binds to the same site at 200 times that of oxygen. CO2 as stated below binds to a different site - the N-Terminal group on the 4 globin chains. The hemoglobin changes shapes and color. When oxygen binds, it changes dark red (unoxygenated) blood to bright red blood. The pulse oximeter is based on the ratio of changing absorbances of red and infrared light caused by the differences in color. CO2 causes no color change. RE: Texas Puzzler I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 16, 2007 Report Share Posted January 16, 2007 Because of Cl- shift??? >>> " Bledsoe, DO " 1/15/2007 12:51 am >>> I know. What does that mean? Where does CO bind? What happens to Hb when O2 binds? _____ From: texasems-l [mailto:texasems-l ] On Behalf Of Sent: Monday, January 15, 2007 12:45 AM To: texasems-l Subject: RE: Texas Puzzler Oxygen binds to the heme component of hemoglobin, CO2 binds to a different site on the hemoglobin (the N-Terminal groups on the 4 globin chains). JT RE: Texas Puzzler I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 16, 2007 Report Share Posted January 16, 2007 No. _____ From: texasems-l [mailto:texasems-l ] On Behalf Of Hudson Sent: Tuesday, January 16, 2007 8:56 AM To: texasems-l Subject: RE: Texas Puzzler Because of Cl- shift??? >>> " Bledsoe, DO " <bbledsoe (AT) earthlink (DOT) <mailto:bbledsoe%40earthlink.net> net> 1/15/2007 12:51 am >>> I know. What does that mean? Where does CO bind? What happens to Hb when O2 binds? _____ From: texasems-l@yahoogro <mailto:texasems-l%40yahoogroups.com> ups.com [mailto:texasems-l@yahoogro <mailto:texasems-l%40yahoogroups.com> ups.com] On Behalf Of Sent: Monday, January 15, 2007 12:45 AM To: texasems-l@yahoogro <mailto:texasems-l%40yahoogroups.com> ups.com Subject: RE: Texas Puzzler Oxygen binds to the heme component of hemoglobin, CO2 binds to a different site on the hemoglobin (the N-Terminal groups on the 4 globin chains). JT RE: Texas Puzzler I will bail off into this mystery. 80%-90% of carbon dioxide in blood is in the form of a bicarbonate ion, 5%-10% is dissolved in blood serum. Current oximtery technology measures the hemoglobin saturation. Only 5%-10% binds to hemoglobin (although not in the same way as oxygen). Still not sure I understand your question, but this addresses current oximetry technology and basic physiology. Quote Link to comment Share on other sites More sharing options...
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