methotrexate

[Guest guest]

I just did a search on methotrexate. I think the most disturbing aspect for

me (as it would apply to young adult females) is the induced miscarriage

aspects. Something to be very aware of for our young adults who may need

treatment for arthritis. I'd hope any doctors prescribing it would make an

individual aware of this aspect. I found this on www.medinenet.com:

GENERIC NAME: methotrexate

BRAND NAMES: Rheumatrex, Trexall

DRUG CLASS AND MECHANISM: Methotrexate is classified as an antimetabolite

drug, which means it is capable of blocking the metabolism of cells. As a

result of this effect, it has been found helpful in treating certain

diseases associated with abnormally rapid cell growth, such as

<http://www.medicinenet.com/script/main/art.asp?articlekey=13931> cancer of

the breast and

<http://www.medicinenet.com/script/main/art.asp?articlekey=459> psoriasis.

Recently, methotrexate has been shown to be effective in inducing

miscarriage, for example in patients with

<http://www.medicinenet.com/script/main/art.asp?articlekey=352> ectopic

pregnancy. This effect of methotrexate is attributed to its action of

killing the rapidly growing cells of the placenta. It has also been found

very helpful in treating

<http://www.medicinenet.com/script/main/art.asp?articlekey=466> rheumatoid

arthritis, although its mechanism of action in this illness is not known. It

seems to work, in part by altering aspects of immune function which may play

a role in causing rheumatoid arthritis.

Friends in CHARGE,

Marilyn Ogan

Mom of (14 yrs, CHARGE+ JRA)

Mom of Ken (17 yrs, Asperger's)

Wife of Rick

oganm@...