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I have managed to go AF-free for long periods but when I do have an

event I invariably have a number in quick succession. One cardio has

suggested the atria remain hyper-sensitive for a number of weeks

following an event making recurrences more likely.

Is this `cluster' effect experienced by fellow AF sufferers?

AG in Wales

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> In the past two months my pattern has been similar to yours.

Hope it is " clustering " and not a deterioration in the effctiveness

of the med and/or the condition. What meds do you take?

>

> Joe Y

Hi Joe,

All I'm taking now is Enalapril (an ACE inhibitor) and Cardizem (a

calcium channel blocker). Also, I tried Toprol XL (a beta blocker)

but it seemed to make me worse, so I only use it occasionally if I

have a longish period of rapid heart rate (150+) during an event. My

Dr. would want to hospitalize me to start Flecainide and my insurance

stinks, so I'm willing to try a while longer to get a handle on

things with less drastic measures. I'm doing 's healthy foods

diet (very limited animal protein, only healthy fats in moderation,

and lots and lots of fruits, veggies and whole grains. I'll give it

a few more months to see if it helps things improve. I think it's a

diet that makes sense even if it doesn't help this problem in my

case.

I just ordered Hans Larsen's book " LONE ATRIAL FIBRILLATION,

TOWARDS A CURE " and want to become better versed in the subtleties

of the condition before committing to an antiarryhmic with even the

remote potential to accidentally induce a fatal arrythmia. I'm also

thinking an ablation or mini-maze surgery may be my best long-term

solution, but would like to delay facing that until the techniques

are more refined, risks lower and results more predictable. With over

2 million US AFers there's lots of incentive for this area to develop

pretty fast and at age 61 I think I can afford to wait a while just

so long as I don't become chronic. I'm learning to avoid some

episodes, reverse some more quickly and ride out the rest with less

discomfort.

Since this is my first New England Winter with AF I'm hoping there's

a seasonal pattern. Perhaps there will be a bit of a lull when it

starts to warm up.

Hartshorn

PS

In my last message I meant to say that serotonin peaks in the AM and

melatonin at Night, and I said the opposite. Sorry if I misled

anyone.

< Is this `cluster' effect experienced by fellow AF sufferers?>

> AG in Wales

> That is certainly the case with me, although in recent months going

> more than a few days without an episode has been problematic. My pattern

> for the 10 months since my lone AF was diagnosed has been

> to have clusters of more or less daily or every-other-day episodes

> for a week or two, and then to go for up to a month with nothing but

> an occasional PVC.

>

> My episodes happen mostly between 9 PM and 8 AM, though I've had a

> few at other times that seem to convert more easily. Typically I

> convert after 2-8 hours either spontaneously or when I start moving

> around after a period of inactivity. Sometimes if I catch it when

> it's starting I can walk it off, but it will frequently recur within

> a few hours when I'm quiet again.

>

> There are daily tides of many hormones and associated factors which

> ebb and flow in regular patterns in response to activity levels,

> eating, emotional states, etc. I've been thinking about how these

> may affect AF. One big daily fluctuation is in the adrenal hormones,

> especially cortisol which has a big surge around the time of

> awakening and then successively smaller pulses throughout the day.

> The periods of lower cortisol levels seem to be when I am most

> vulnerable. I'm more likely to have problems when I'm over tired,

> which probably coincides with periods of cortisol depletion. There

> are many other biochemicals fluctutating in similar rhythms

> (melatonin and serotonin for example, which peak in the morning and

> night respectively, and contribute to alertness and sleepiness).

> This area seems worth investigating though I've had no great insights

> so far.

>

> Hartshorn

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> In the past two months my pattern has been similar to yours.

Hope it is " clustering " and not a deterioration in the effctiveness

of the med and/or the condition. What meds do you take?

>

> Joe Y

Hi Joe,

All I'm taking now is Enalapril (an ACE inhibitor) and Cardizem (a

calcium channel blocker). Also, I tried Toprol XL (a beta blocker)

but it seemed to make me worse, so I only use it occasionally if I

have a longish period of rapid heart rate (150+) during an event. My

Dr. would want to hospitalize me to start Flecainide and my insurance

stinks, so I'm willing to try a while longer to get a handle on

things with less drastic measures. I'm doing 's healthy foods

diet (very limited animal protein, only healthy fats in moderation,

and lots and lots of fruits, veggies and whole grains. I'll give it

a few more months to see if it helps things improve. I think it's a

diet that makes sense even if it doesn't help this problem in my

case.

I just ordered Hans Larsen's book " LONE ATRIAL FIBRILLATION,

TOWARDS A CURE " and want to become better versed in the subtleties

of the condition before committing to an antiarryhmic with even the

remote potential to accidentally induce a fatal arrythmia. I'm also

thinking an ablation or mini-maze surgery may be my best long-term

solution, but would like to delay facing that until the techniques

are more refined, risks lower and results more predictable. With over

2 million US AFers there's lots of incentive for this area to develop

pretty fast and at age 61 I think I can afford to wait a while just

so long as I don't become chronic. I'm learning to avoid some

episodes, reverse some more quickly and ride out the rest with less

discomfort.

Since this is my first New England Winter with AF I'm hoping there's

a seasonal pattern. Perhaps there will be a bit of a lull when it

starts to warm up.

Hartshorn

PS

In my last message I meant to say that serotonin peaks in the AM and

melatonin at Night, and I said the opposite. Sorry if I misled

anyone.

< Is this `cluster' effect experienced by fellow AF sufferers?>

> AG in Wales

> That is certainly the case with me, although in recent months going

> more than a few days without an episode has been problematic. My pattern

> for the 10 months since my lone AF was diagnosed has been

> to have clusters of more or less daily or every-other-day episodes

> for a week or two, and then to go for up to a month with nothing but

> an occasional PVC.

>

> My episodes happen mostly between 9 PM and 8 AM, though I've had a

> few at other times that seem to convert more easily. Typically I

> convert after 2-8 hours either spontaneously or when I start moving

> around after a period of inactivity. Sometimes if I catch it when

> it's starting I can walk it off, but it will frequently recur within

> a few hours when I'm quiet again.

>

> There are daily tides of many hormones and associated factors which

> ebb and flow in regular patterns in response to activity levels,

> eating, emotional states, etc. I've been thinking about how these

> may affect AF. One big daily fluctuation is in the adrenal hormones,

> especially cortisol which has a big surge around the time of

> awakening and then successively smaller pulses throughout the day.

> The periods of lower cortisol levels seem to be when I am most

> vulnerable. I'm more likely to have problems when I'm over tired,

> which probably coincides with periods of cortisol depletion. There

> are many other biochemicals fluctutating in similar rhythms

> (melatonin and serotonin for example, which peak in the morning and

> night respectively, and contribute to alertness and sleepiness).

> This area seems worth investigating though I've had no great insights

> so far.

>

> Hartshorn

------- End of forwarded message -------

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Hi :

It seems that you know you want. Hope your clusters diminish in

frequency and load, so that you can wait avoid use of antiarrhythmic

drugs and afford the docs more time to learn their ablation.

All the best

Joe Y.

RE: AF clusters

> In the past two months my pattern has been similar to yours.

Hope it is " clustering " and not a deterioration in the effctiveness

of the med and/or the condition. What meds do you take?

>

> Joe Y

Hi Joe,

All I'm taking now is Enalapril (an ACE inhibitor) and Cardizem (a

calcium channel blocker). Also, I tried Toprol XL (a beta blocker)

but it seemed to make me worse, so I only use it occasionally if I

have a longish period of rapid heart rate (150+) during an event. My

Dr. would want to hospitalize me to start Flecainide and my insurance

stinks, so I'm willing to try a while longer to get a handle on

things with less drastic measures. I'm doing 's healthy foods

diet (very limited animal protein, only healthy fats in moderation,

and lots and lots of fruits, veggies and whole grains. I'll give it

a few more months to see if it helps things improve. I think it's a

diet that makes sense even if it doesn't help this problem in my

case.

I just ordered Hans Larsen's book " LONE ATRIAL FIBRILLATION, TOWARDS A

CURE " and want to become better versed in the subtleties

of the condition before committing to an antiarryhmic with even the

remote potential to accidentally induce a fatal arrythmia. I'm also

thinking an ablation or mini-maze surgery may be my best long-term

solution, but would like to delay facing that until the techniques

are more refined, risks lower and results more predictable. With over

2 million US AFers there's lots of incentive for this area to develop

pretty fast and at age 61 I think I can afford to wait a while just

so long as I don't become chronic. I'm learning to avoid some

episodes, reverse some more quickly and ride out the rest with less

discomfort.

Since this is my first New England Winter with AF I'm hoping there's

a seasonal pattern. Perhaps there will be a bit of a lull when it

starts to warm up.

Hartshorn

PS

In my last message I meant to say that serotonin peaks in the AM and

melatonin at Night, and I said the opposite. Sorry if I misled

anyone.

< Is this `cluster' effect experienced by fellow AF sufferers?> > AG

in Wales

> That is certainly the case with me, although in recent months going

> more than a few days without an episode has been problematic. My

pattern

> for the 10 months since my lone AF was diagnosed has been

> to have clusters of more or less daily or every-other-day episodes

> for a week or two, and then to go for up to a month with nothing but

> an occasional PVC.

>

> My episodes happen mostly between 9 PM and 8 AM, though I've had a

> few at other times that seem to convert more easily. Typically I

> convert after 2-8 hours either spontaneously or when I start moving

> around after a period of inactivity. Sometimes if I catch it when

> it's starting I can walk it off, but it will frequently recur within

> a few hours when I'm quiet again.

>

> There are daily tides of many hormones and associated factors which

> ebb and flow in regular patterns in response to activity levels,

> eating, emotional states, etc. I've been thinking about how these

> may affect AF. One big daily fluctuation is in the adrenal hormones,

> especially cortisol which has a big surge around the time of

> awakening and then successively smaller pulses throughout the day.

> The periods of lower cortisol levels seem to be when I am most

> vulnerable. I'm more likely to have problems when I'm over tired,

> which probably coincides with periods of cortisol depletion. There

> are many other biochemicals fluctutating in similar rhythms

> (melatonin and serotonin for example, which peak in the morning and

> night respectively, and contribute to alertness and sleepiness).

> This area seems worth investigating though I've had no great insights

> so far.

>

> Hartshorn

------- End of forwarded message -------

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Nothing in this message should be considered as medical advice, or

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