Re: Erythromycin: ototoxic?

[Guest guest]

I believe you are correct.

BDS31@... wrote:

>Hi,

>My new GI doc says that the only medicine left for him to prescribe for

>my motility problems is erythromycin. I told him that I thought that the

>antibiotics with the suffix -mycin can cause hearing deterioration and

>tinnitus. Since I am losing my hearing, I don't want to jeopardize it

>any further.

>I would appreciate your advice.

>Thanks so very much.

>

>

>

>Medical advice, information, opinions, data and statements contained herein are

not necessarily those of the list moderators. The author of this e mail is

entirely responsible for its content. List members are reminded of their

responsibility to evaluate the content of the postings and consult with their

physicians regarding changes in their own treatment.

>

>Personal attacks are not permitted on the list and anyone who sends one is

automatically moderated or removed depending on the severity of the attack.

>

>

>

[Guest guest]

Dear ,

Thanks for your quick response. I am afraid that we are both right!

Sincerely,

[Guest guest]

Here is a listing of otoxic drugs.

http://www.tchain.com/otoneurology/disorders/bilat/ototoxins.html

Re: Erythromycin: ototoxic?

Dear ,Thanks for your quick response. I am afraid that we are both right!Sincerely,Medical advice, information, opinions, data and statements contained herein are not necessarily those of the list moderators. The author of this e mail is entirely responsible for its content. List members are reminded of their responsibility to evaluate the content of the postings and consult with their physicians regarding changes in their own treatment.Personal attacks are not permitted on the list and anyone who sends one is automatically moderated or removed depending on the severity of the attack.

[Guest guest]

I should have added that Erythromycin is an otoxic drug.

Alice

Re: Erythromycin: ototoxic?

Dear ,Thanks for your quick response. I am afraid that we are both right!Sincerely,Medical advice, information, opinions, data and statements contained herein are not necessarily those of the list moderators. The author of this e mail is entirely responsible for its content. List members are reminded of their responsibility to evaluate the content of the postings and consult with their physicians regarding changes in their own treatment.Personal attacks are not permitted on the list and anyone who sends one is automatically moderated or removed depending on the severity of the attack.

[Guest guest]

Dear Alice,

The info you posted for me is PERFECT! Thanks so much; I will print it

out and give it to the doctor.

So, the above drug only seems dangerous at high IV dosages. I still

don't think I am willing to take it.

Thanks for all of your help.

Sincerely,

Here is a listing of otoxic drugs.

http://www.tchain.com/otoneurology/disorders/bilat/ototoxins.html

Re: Erythromycin: ototoxic?

Dear ,Thanks for your quick response. I am afraid that we are both right!Sincerely,Medical advice, information, opinions, data and statements contained herein are not necessarily those of the list moderators. The author of this e mail is entirely responsible for its content. List members are reminded of their responsibility to evaluate the content of the postings and consult with their physicians regarding changes in their own treatment.Personal attacks are not permitted on the list and anyone who sends one is automatically moderated or removed depending on the severity of the attack.

[Guest guest]

I noticed from Alice's link is that it takes high IV doses of Erythromycin to be toxic to hearing loss. That is a good link Alice. I would still be very careful with erythromycin as I know that I am hypersensitive to medications, and it takes just a minute dose of medication to have the same affect on me as a standard dose does for the average person. I wish that was true with the vitamin supplements. It would save me a bundle of money Cheers. Ruth

-----Original Message-----From: Alice Sent: Monday, January 05, 2004 9:12 PMTo: Subject: Re: Erythromycin: ototoxic?

Here is a listing of otoxic drugs.

http://www.tchain.com/otoneurology/disorders/bilat/ototoxins.html

Re: Erythromycin: ototoxic?

Dear ,Thanks for your quick response. I am afraid that we are both right!Sincerely,Medical advice, information, opinions, data and statements contained herein are not necessarily those of the list moderators. The author of this e mail is entirely responsible for its content. List members are reminded of their responsibility to evaluate the content of the postings and consult with their physicians regarding changes in their own treatment.Personal attacks are not permitted on the list and anyone who sends one is automatically moderated or removed depending on the severity of the attack.

[Guest guest]

Here is a listing of otoxic drugs.

http://www.tchain.com/otoneurology/disorders/bilat/ototoxins.html

----- Original Message -----

Erythromycin may be ototoxic in general, but I am not sure it carries any increased risk b/c of having a mitochondrial disease. There is a class of antibiotics called aminoglycosides which often end in mycin and those are mito toxic in some people with mito. However, erythromycin is actually in another class of antibiotics called macrolides, even though it ends in the mycin ending. To my knowledge, macrolide antibiotics don't have an increased risk of ototoxicity in the mito population, but I could be wrong.

I have taken erythromycin before for gastroparesis and know others with mito who have as well, with no problems. The dose that is used for gastroparesis is less than what is used for the regular uses of the antibiotic.

Malisa

[Guest guest]

Dear Malisa,

Thanks for taking the time and effort to send me all of this info. Since

I have both gastroparesis and severe hearing loss, I think I will err on

the side of caution and refuse to take eryththromycin.

Do you have hearing loss, too? I would hate to see your hearing damaged

in trying to alleviate the gp. What dilemmas we mito folk have!

Thanks.

[Guest guest]

Thanks for taking the time and effort to send me all of this info. SinceI have both gastroparesis and severe hearing loss, I think I will err onthe side of caution and refuse to take eryththromycin.Do you have hearing loss, too? I would hate to see your hearing damagedin trying to alleviate the gp. What dilemmas we mito folk have!Thanks.

Hi ,

UGH. I didn't realize you had hearing loss too....that makes sense why you are so cautious.

I don't have any hearing loss. I did get vestibular damage (located in the inner ear) from gentamicin last year and still suffer the effects of that (although it has gotten better over time). They think I may have a higher susceptability to ototoxicity/vestibulotoxicity with certain antibiotics b/c of mito. I am not allowed to get even one dose of an aminoglycoside b/c it may permanently destroy my vestibular system.

I am not taking erthyrtho now but when I did in the past I never had any trouble with side effects with it.

Hope you find something to help with your GI issues!

Hugs, Malisa

[Guest guest]

I was told the effects are most likely cummulative.

Malilibear@... wrote:

In a message dated 1/7/2004 8:15:40 AM Eastern Standard Time,

BDS31@... writes:

Thanks for taking the time and effort to send me all of

this info. Since

I have both gastroparesis and severe hearing loss, I think I will err on

the side of caution and refuse to take eryththromycin.

Do you have hearing loss, too? I would hate to see your hearing damaged

in trying to alleviate the gp. What dilemmas we mito folk have!

Thanks.

Hi ,

UGH. I didn't realize you had hearing loss too....that makes

sense why you are so cautious.

I don't have any hearing loss. I did get vestibular damage

(located in the inner ear) from gentamicin last year and still suffer

the effects of that (although it has gotten better over time). They

think I may have a higher susceptability to

ototoxicity/vestibulotoxicity with certain antibiotics b/c of mito. I

am not allowed to get even one dose of an aminoglycoside b/c it may

permanently destroy my vestibular system.

I am not taking erthyrtho now but when I did in the past I never

had any trouble with side effects with it.

Hope you find something to help with your GI issues!

Hugs, Malisa

Medical advice, information, opinions, data and statements contained

herein are not necessarily those of the list moderators. The author of

this e mail is entirely responsible for its content. List members are

reminded of their responsibility to evaluate the content of the

postings and consult with their physicians regarding changes in their

own treatment.

Personal attacks are not permitted on the list and anyone who sends one

is automatically moderated or removed depending on the severity of the

attack.

[Guest guest]

I was on Erythromycin a lot growing up (at least 50 courses) and have

no hearing problems as of yet.

But I also have profound deafness in my family, so I'm a little

worried about my kids' hearing.

Take care,

RH

> In a message dated 1/7/2004 8:15:40 AM Eastern Standard Time,

BDS31@w...

> writes:

> Thanks for taking the time and effort to send me all of this info.

Since

> I have both gastroparesis and severe hearing loss, I think I will

err on

> the side of caution and refuse to take eryththromycin.

> Do you have hearing loss, too? I would hate to see your hearing

damaged

> in trying to alleviate the gp. What dilemmas we mito folk have!

> Thanks.

> Hi ,

> UGH. I didn't realize you had hearing loss too....that makes sense

why you

> are so cautious.

> I don't have any hearing loss. I did get vestibular damage (located

in the

> inner ear) from gentamicin last year and still suffer the effects

of that

> (although it has gotten better over time). They think I may have a

higher

> susceptability to ototoxicity/vestibulotoxicity with certain

antibiotics b/c of mito. I

> am not allowed to get even one dose of an aminoglycoside b/c it may

> permanently destroy my vestibular system.

> I am not taking erthyrtho now but when I did in the past I never

had any

> trouble with side effects with it.

> Hope you find something to help with your GI issues!

> Hugs, Malisa