Re: Lactate & pyruvate w/exercise

[Guest guest]

Hi Malisa! I wish I had an answer for you. I am still waiting for my Dr. to order my exercise test. She is supposed to call me today re MRI and furthur tests. I hate waiting. It stinks waiting for test results. I hope you find the answers soon!

Hi Dawn,

Yes...waiting is very hard! I am also waiting for the muscle biopsy results and it will probably be another month or so before I get them. I hope your doctor calls you today about your tests. They got a lot of info. from the exercise test about my lungs, heart, and muscles, as well as the lactic acid results, so hopefully it will be just as useful for you, too.

Have a great holiday!

Malisa

"Wherever life takes us, there are always moments of wonder."President Jimmy

[Guest guest]

--- Hi Malisa! I wish I had an answer for you. I am still waiting

for my Dr. to order my exercise test. She is supposed to call me

today re MRI and furthur tests. I hate waiting. It stinks waiting

for test results. I hope you find the answers soon!

Happy Holidays,

Dawn

In , Malilibear@a... wrote:

> Hi everyone,

> For those of you who have had exercise tests with lactic acid

levels measured

> afterwards, what was considered an abnormal result?

> I had a treadmill exercise test done last week. The lactic acid

beforehand

> was 0.87 and it rose to 8.4 with 10-15 minutes of walking on the

treadmill. The

> lactate/pyruvate ratio was 8.7 before exercise and 30 after

exercise. Pyruvate

> before and after were 0.1 & 0.28. My TPN pharmacist said, based on

something

> he read, that the lactate/pyruvate ratio needs to be over 50 to be

considered

> abnormal after exercise. The local geneticist said that a lactate

over 2-5

> would be considered abnormal w/exercise, but he's away all week so

I can't ask

> him any further details at the moment.

> Just curious what other experiences may have been. I know what the

resting

> norms are, but does anyone know of anything published by Cohen or

others that

> reference norms after exercise?

> Thanks!!

> Malisa

[Guest guest]

Lynn,

I am only guessing here, but I would think that you couldn't tell from

one test to another unless the machines used were the same. Blood labs

are different from one lab to another in their ranges for normal, etc,

so I am thinking the equipment for the exercise test might follow along

the same lines. Anybody else have more than just a guess for Lynn?

Lynn Zona wrote:

Hi Malisa,

I was wondering if you found out what the

norms should be for the exercise test. I had a stationary bicycle test

yesterday and was wondering what I should expected. I rode the bike for

15 minutes. They drew blood before, after 1 minute, after five minutes

after 15 minutes and after 30 minutes. They are testing for lactose and

pyruvate. Any insight would be appreciated.

Lynn

-----

Original Message -----

From:

Malilibear@...

To:

Sent:

Monday, December 22, 2003 9:46 PM

Subject:

Lactate & pyruvate w/exercise

Hi everyone,

For those of you who have had exercise tests with lactic acid

levels measured afterwards, what was considered an abnormal result?

I had a treadmill exercise test done last week. The lactic

acid beforehand was 0.87 and it rose to 8.4 with 10-15 minutes of

walking on the treadmill. The lactate/pyruvate ratio was 8.7 before

exercise and 30 after exercise. Pyruvate before and after were 0.1

& 0.28. My TPN pharmacist said, based on something he read,

that the lactate/pyruvate ratio needs to be over 50 to be considered

abnormal after exercise. The local geneticist said that a lactate over

2-5 would be considered abnormal w/exercise, but he's away all week so

I can't ask him any further details at the moment.

Just curious what other experiences may have been. I know what

the resting norms are, but does anyone know of anything published by

Cohen or others that reference norms after exercise?

Thanks!!

Malisa

Medical advice, information, opinions, data and statements

contained herein are not necessarily those of the list moderators. The

author of this e mail is entirely responsible for its content. List

members are reminded of their responsibility to evaluate the content of

the postings and consult with their physicians regarding changes in

their own treatment.

Personal attacks are not permitted on the list and anyone who sends one

is automatically moderated or removed depending on the severity of the

attack.

[Guest guest]

Lynn,

I am only guessing here, but I would think that you couldn't tell from

one test to another unless the machines used were the same. Blood labs

are different from one lab to another in their ranges for normal, etc,

so I am thinking the equipment for the exercise test might follow along

the same lines. Anybody else have more than just a guess for Lynn?

Lynn Zona wrote:

Hi Malisa,

I was wondering if you found out what the

norms should be for the exercise test. I had a stationary bicycle test

yesterday and was wondering what I should expected. I rode the bike for

15 minutes. They drew blood before, after 1 minute, after five minutes

after 15 minutes and after 30 minutes. They are testing for lactose and

pyruvate. Any insight would be appreciated.

Lynn

-----

Original Message -----

From:

Malilibear@...

To:

Sent:

Monday, December 22, 2003 9:46 PM

Subject:

Lactate & pyruvate w/exercise

Hi everyone,

For those of you who have had exercise tests with lactic acid

levels measured afterwards, what was considered an abnormal result?

I had a treadmill exercise test done last week. The lactic

acid beforehand was 0.87 and it rose to 8.4 with 10-15 minutes of

walking on the treadmill. The lactate/pyruvate ratio was 8.7 before

exercise and 30 after exercise. Pyruvate before and after were 0.1

& 0.28. My TPN pharmacist said, based on something he read,

that the lactate/pyruvate ratio needs to be over 50 to be considered

abnormal after exercise. The local geneticist said that a lactate over

2-5 would be considered abnormal w/exercise, but he's away all week so

I can't ask him any further details at the moment.

Just curious what other experiences may have been. I know what

the resting norms are, but does anyone know of anything published by

Cohen or others that reference norms after exercise?

Thanks!!

Malisa

Medical advice, information, opinions, data and statements

contained herein are not necessarily those of the list moderators. The

author of this e mail is entirely responsible for its content. List

members are reminded of their responsibility to evaluate the content of

the postings and consult with their physicians regarding changes in

their own treatment.

Personal attacks are not permitted on the list and anyone who sends one

is automatically moderated or removed depending on the severity of the

attack.

[Guest guest]

Hi Malisa,

I was wondering if you found out what the norms should be for the exercise test. I had a stationary bicycle test yesterday and was wondering what I should expected. I rode the bike for 15 minutes. They drew blood before, after 1 minute, after five minutes after 15 minutes and after 30 minutes. They are testing for lactose and pyruvate. Any insight would be appreciated.

Lynn

Lactate & pyruvate w/exercise

Hi everyone,

For those of you who have had exercise tests with lactic acid levels measured afterwards, what was considered an abnormal result?

I had a treadmill exercise test done last week. The lactic acid beforehand was 0.87 and it rose to 8.4 with 10-15 minutes of walking on the treadmill. The lactate/pyruvate ratio was 8.7 before exercise and 30 after exercise. Pyruvate before and after were 0.1 & 0.28. My TPN pharmacist said, based on something he read, that the lactate/pyruvate ratio needs to be over 50 to be considered abnormal after exercise. The local geneticist said that a lactate over 2-5 would be considered abnormal w/exercise, but he's away all week so I can't ask him any further details at the moment.

Just curious what other experiences may have been. I know what the resting norms are, but does anyone know of anything published by Cohen or others that reference norms after exercise?

Thanks!!

Malisa

Medical advice, information, opinions, data and statements contained herein are not necessarily those of the list moderators. The author of this e mail is entirely responsible for its content. List members are reminded of their responsibility to evaluate the content of the postings and consult with their physicians regarding changes in their own treatment.Personal attacks are not permitted on the list and anyone who sends one is automatically moderated or removed depending on the severity of the attack.

[Guest guest]

I was wondering if you found out what the norms should be for the exercise test. I had a stationary bicycle test yesterday and was wondering what I should expected. I rode the bike for 15 minutes. They drew blood before, after 1 minute, after five minutes after 15 minutes and after 30 minutes. They are testing for lactose and pyruvate. Any insight would be appreciated.

Hi Lynn,

I don't know too much more at this point other than understanding that the results I had weren't normal and pointed towards a mitochondrial defect. Below is what the local geneticist e-mailed me, although I am not sure if it applies to everyone. Your doctor may have a different interpretation. This geneticist also said he felt that lactate may increase up to 5 (norm up to 2.5) after exercise, but shouldn't go much higher than that (just his opinion). I am waiting to hear from my mito doctor what he thinks about it. I also exercised for approx. 15 minutes. Let me know what you find out!

Malisa

----------------------------------------------------------

From my geneticist in Phila.: My lactate increased from 0.87 to 8.4 afterwards. Lactate/pyruvate ratio was 30.

---------

When you have an almost 10 fold increase in lactate we should conclude that your interpretation of pre and post exercise is correct. It is important that you have normal lactate and L/P at rest. This makes a primary electron transport chain defect unlikely. I find a ratio of 30 to be significant given your history. Given that the resting L/P is normal it is my guess that any electron transport deficiency is secondary to a more global mitochondrial problem - the muscle biopsy is what counts here.Lactate goes down in a matter of an hour after exercise. The liver helps clear lactate produced in excess by the muscles.

[Guest guest]

Malisa,

Thanks for the info. My lactate and pyruvate levels were as follows:

Baseline - Pyruvate: .81 Lactate: 11.8

1 minute after exercising for 15 min - P: .82 L: 17.8

5 min after - P: .79 L: 13.9

15 min after: P: .70 L: 12.6

30 min after: P: .59 L: 9.5

I'll let you know how my doctor interprets the results.

Lynn

Re: Lactate & pyruvate w/exercise

I was wondering if you found out what the norms should be for the exercise test. I had a stationary bicycle test yesterday and was wondering what I should expected. I rode the bike for 15 minutes. They drew blood before, after 1 minute, after five minutes after 15 minutes and after 30 minutes. They are testing for lactose and pyruvate. Any insight would be appreciated.

Hi Lynn,

I don't know too much more at this point other than understanding that the results I had weren't normal and pointed towards a mitochondrial defect. Below is what the local geneticist e-mailed me, although I am not sure if it applies to everyone. Your doctor may have a different interpretation. This geneticist also said he felt that lactate may increase up to 5 (norm up to 2.5) after exercise, but shouldn't go much higher than that (just his opinion). I am waiting to hear from my mito doctor what he thinks about it. I also exercised for approx. 15 minutes. Let me know what you find out!

Malisa

----------------------------------------------------------

From my geneticist in Phila.: My lactate increased from 0.87 to 8.4 afterwards. Lactate/pyruvate ratio was 30.

---------

When you have an almost 10 fold increase in lactate we should conclude that your interpretation of pre and post exercise is correct. It is important that you have normal lactate and L/P at rest. This makes a primary electron transport chain defect unlikely. I find a ratio of 30 to be significant given your history. Given that the resting L/P is normal it is my guess that any electron transport deficiency is secondary to a more global mitochondrial problem - the muscle biopsy is what counts here.Lactate goes down in a matter of an hour after exercise. The liver helps clear lactate produced in excess by the muscles.Medical advice, information, opinions, data and statements contained herein are not necessarily those of the list moderators. The author of this e mail is entirely responsible for its content. List members are reminded of their responsibility to evaluate the content of the postings and consult with their physicians regarding changes in their own treatment.Personal attacks are not permitted on the list and anyone who sends one is automatically moderated or removed depending on the severity of the attack.