Guest guest Posted August 19, 2003 Report Share Posted August 19, 2003 I saw this in the latest MDA Quest magazine: A high level of lactic acid in the blood - which can damage the nervous system and muscles - is a common effect of many mitochondrial disorders. The drug dichloroacetate (DCA) has shown some promise in lowering lactic acid levels and improving symptoms in some people, but it can have undesirable side effects, such as liver and nerve damage. Now, investigators at the University of Florida in Gainesville, working under a grant from the U.S. Food and Drug Administration, want to find out how effective DCA is, and whether they can reduce its side effects by adding another drug, nitisinone (Orfadin). Study participation requirements include having a clear diagnosis of mitochondrial disease with high lactic acid levels, the ability to fast for 8 to 12 hours while maintaining blood sugar levels, and an agreement to follow a restricted diet during the study. Contact Stacpoole or Margaret Francis at or francma@... Quote Link to comment Share on other sites More sharing options...
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