TESTOSTERONE * INCREASES E. RECEPTORS!

[Guest guest]

HI all.

I do hope most of you read this even if you think it might not interest you as I think it will be beneficial. I hope so anyway. It sort of lays the background in a small way as to 'why' certains meds may work and why the T (to me) can be SO beneficial..

I know a lot of you aren't into the more technical or research end of this but I am *grin* so you'll have to put up with me here for a bit. *chuckle*

I've often explained how it's probable that our Estrogen & Testosterone (E & T) hormone ''receptors'' are either diminished or lost with age or who knows why as it may be genetic as well and why the E & T can be so beneficial.

The ''receptors'' ® are the active part that opens the cell to do it's job and when they're blocked they cannot function as they're meant to ...Just like a lock and key and with the right key the door opens... but with the wrong one... it jams the lock and blocks the cell from performing properly.

Some of those blocks (wrong keys) are things like soy, and especially progesterone & progestins. Also birth control pills (mainly progestins), tamoxifen for breast cancer and others that puposely 'block' the Estrogen and Testosterone (E & T) receptors ®... But keep in mind there may be a need for them in some cases say for someone with breast cancer or needs the birth control or perhaps someone with PCO or possibly Endo where you might need to block those hormones.

That's one way that birth control pills can even contribute to V. pain... they block the estrogen and testosterone we need with progestins. But that's what it's supposed to do, in order to prevent pregnancy,... but.... it has it's side effects with that loss of estrogen and testosterone benefits.

During my own healing I was using the Estrace alone (and very slowly) for approx. 4 months and in that time I did unfuse and the tissue finally 'looked' great... but I was still tender and sort of ouchy... and when I finally added the T. cream for the next two months along with my E... is was what finally put me over the hump to full and total wellness.

Now at the time I had no idea of the 'why' of it...I was just thrilled to finally be able to have sex again with no pain after 3 yrs of celebacy (the last 3 yrs of the 10 that I suffered) but I think this piece I'm going to add may be a big part of the puzzle and it made so much sense to 'me'. And by the way this is not JUST beneficial for LS but you'll see squamous hyperplasia (SH) here as well.

Sorry for that long explanation above but felt it was needed to try to understand what I'm going to add as it shows' how the topical T.... helps to increase the E. 'receptors' so it was no wonder it took the combination for me by increasing my E. receptors to help even more, that was the icing on the cake.. Hope it doesn't bore you but 'I' was so excited to have this. *grin* (forgive my own notes*)

Dee~

Topical T increases the number of E receptors.

Abstract

Capobianco G., Dessole S., Cossu A., Marras V., Meloni G.B., Mesina S., Demurtas P., Cherchi P.L.

‘’Receptor modifications in vulvar dystrophies before and after treatment with topical hormones: Comparison between the dextran-charcoal technique and immunohistochemical evaluation’’

(2006) European Journal of Gynaecological Oncology, 27 (4), pp. 411-413.

Department of Pharmacology, Gynecology and Obstetrics, University of Sassari, Sassari, Italy Institute of Pathologic Anatomy, University of Sassari, Sassari, Italy

Dept. of Pharmacology, Gynecology and Obstetrics, University of Sassari, Viale San Pietro, 12, 07100 Sassari, Italy

Abstract

Purpose of investigation:

The objective of the study was first to quantify estrogen receptors (ERs) and progesterone receptors (PRs) in dystrophic vulvar tissue before and after topical hormone treatment in an attempt to evaluate whether receptor modifications occurred. Second we compared quantitative analysis with immunohistochemical staining of the vulvar specimens.

Methods:

We studied 115 vulvar specimens obtained from 75 consenting women ranging from 21 to 78 years of age.

Of the patients,

12 had histologically normal vulvar skin,

45 had vulvar dystrophies that were not treated by topical steroid therapy,

28 patients had vulvar dystrophies that were treated by testosterone propionate (TP) 2%,

12 patients had vulvar dystrophies that were treated by progesterone in hydroalcoholic gel and

18 patients had vulvar malignant tumors.

For immunohistochemical analysis we considered 25 cases of vulvar dystrophies:

11 cases of squamous hyperplasia (SH) and

14 cases of lichen sclerosus (LS)

Among these 25 cases,

15 (5 SH and 10 LS) were treated with TP 2%. (testosterone propionate)

Results:

After treatment of the vulvar dystrophies with progesterone, the positivity of ERs (estrogen receptors) ‘’decreased’’ (58.3% vs. 77.8%).

(Dee's comment: As I mentioned above, (P) Progestone 'blocks' or 'decreases those E receptors and in this paper it showed that using the Progesterone the E receptors decreased. They only talk about the E 'receptors' here but it does the same with the T. receptors as well so that above doesn't surprise me)

After treatment of the vulvar dystrophies with TP 2%, the positivity of PRs (progesterone receptors) significantly 'decreased' (14.3% vs. 68.9%) whereas after treatment with ‘progesterone’ the positivity of PRs (progesterone receptors) 'increased' (83.3%).

Comment: That simply means (if I'm correct) that using the topical testosterone lessened the progesterone receptors significantly (which is what 'I' would want).... but using the progesterone those progesterone 'receptors' (PR) increased considerably, and we know that P blocks the E. (and T) and why "I" wouldn't want that. Dee

The immunohistochemical study showed some differences in comparison to the quantitative study.

In fact we found low basal positivity especially for PRs (16% vs. 68.9% of the quantitative study).

This finding was due to the use of a cutoff of at least ++ in order to increase the specificity.

After treatment with TP 2 %, (testosterone propionate) we observed an increase of immunohistochemical ‘’positivity for ERs’’ (estrogen receptors) even in cases that were negative before treatment and a lack of PRs (progesterone receptors) even in cases that were positive before treatment.

Comment: So after treatment using the testosterone there was an 'increase' in the E. (estrogen) receptors even in cases that were negative before, and it also diminished the P.. receptors.. THAT is why once I added the T. it helped increase those E. receptors to give me even MORE benefits and did finally get me totally well. (I do maintain that tissue though with both the E & T once or twice a week now to 'keep' me well)

Conclusions:

These data demonstrate the efficacy of androgen therapy with TP 2% in vulvar dystrophies with increased trophism due to the increase of ERs.

(NOTE* Trophism means 'Nutrition & Nourishment' * and that was due to the increased E. Receptors by the use of testosterone. Dee T) .

Author Keywords

Lichen sclerosus; Receptor modifications; Squamous hyperplasia; Vulvar dystrophies

References

- Ambrosini, A.: Dystrophic lesions of the vulva. Evaluation and treatment

(1987) Proc. Int. Meet. Gynecol. Oncol., 233, p. 54.

- , Y.R., Haefner, H.K.

Vulvar lichen sclerosus

(2004) Am. J. Clin. Dermatol., 5, p. 105.

- Johansson, R., Gronross, M., Kouvonen, I., Lovgren, T.

Oestrogen receptors in dysplastic and malignant vulval tissue

(1979) Acta Obstet. Gynecol. Scand., 58, p. 213.

- Becagli, L., Scrimin, F., De Salvia, D., Gambato, M., Resta, P., Ambrosini, A.

Hormone receptors in dystrophic and neoplastic vulvar disease. Preliminary considerations

(1983) Clin. Exp. Obstet. Gynecol., 23, p. 145.

- Fiorucci-Zulli, M., Gaglione, R., Gentiloni, N., Scambia, G., De Stefani, L., Iacobelli, S.

Sex steroid receptors in normal and malignant human vulvar tissue

(1985) Gynecol. Obstet. Invest., 19, p. 103.

- Onnis, A., Nardelli, G.B., Becagli, L., Maggino, T., Marchetti, M.

Androgen, estrogen and progesterone receptors in vulvar dystrophy

(1983) Clin. Exp. Obstet. Gynecol., 10, p. 159.

- Nardelli, G.B.

Vulvar hormonal receptor modifications during topical steroid treatment

(1988) Clin. Exp. Obstet. Gynecol., 15, p. 170.

- Onnis, A., Nardelli, G.B., Lamaina, V., Mozzanega, B., Becagli, L., Fais, G.F.

Hormonal receptors in vulvar tissues

(1985) Eur. J. Gynaecol. Oncol., 6, p. 125.

- Hodgins, M.B., Spike, R.C., Mackie, R.M., McLean, A.B.

An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina

(1998) Br. J. Gynaecol. Obstet., 105, p. 216.

Document Type: Article

Source: Scopus