CYMBALTA clip & nausea

[Guest guest]

Some few other things I have on cymbalta,

That's enough. *grin* Dee~

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http://www.fda.gov/medwatch/safety/2005/safety05.htm#Cymbalta

Cymbalta (duloxetine hydrochloride)

Audience: Neuropsychiatric and other healthcare professionals

Eli Lilly and FDA notified healthcare professionals of revision to the PRECAUTIONS/Hepatotoxicity section of the prescribing information for Cymbalta (duloxetine hydrochloride), indicated for treatment of major depressive disorder and diabetic peripheral neuropathic pain. Postmarketing reports of hepatic injury (including hepatitis and cholestatic jaundice) suggest that patients with preexisting liver disease who take duloxetine may have an increased risk for further liver damage. The new labeling extends the Precaution against using Cymbalta in patients with substantial alcohol use to include those patients with chronic liver disease. It is recommended that Cymbalta not be administered to patients with any hepatic insufficiency. [October 05, 2005 - Letter - Eli Lilly] [september 2005 - Label - Eli Lilly]

small clip from letter Oct 5,05

....''Patients and prescribers should be aware of the signs and symptoms of liver damage (pruritus, dark urine, jaundice, right upper quadrant tenderness, or unexplained "flu-like"symptoms) and health care professionals are encouraged to investigate such symptoms and signs promptly.''..

http://www.fda.gov/medwatch/safety/2005/Cymbalta_DearHCP05OCT2005.FINALSIGNED.pdf

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http://news.monstersandcritics.com/health/printer_1049122.php

clip only......

.......Dr. Ferrante, director of the Pain and Spine Care Center at the UCLA Medical Center in Los Angeles, said he would be delighted to see new pharmaceuticals developed for neuropathic pain in the near future.

Neurontin was a great step forward because it had a low side-effect profile and produced very quick results, Ferrante told United Press International.

Cymbalta, the newest medication, is more effective, but carries a significant risk of nausea.

Lyrica is five times as effective as Neurontin, with a similar low side-effect profile, but is listed as a scheduled medication because it can potentially cause euphoria.