Statin interaction

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Statins and Cytochrome P450 Inhibitors May Interact

Date: Tuesday, December 21 @ 12:22:10 EST

Topic: DIC Newsletter Issue 239

Coadministration of certain statin drugs with cytochrome P450-3A4

(CYP3A4) inhibitors should be avoided.

" Although exceedingly well tolerated, treatment with statins incurs a

small risk of myopathy or potentially fatal rhabdomyolysis, particularly

when co-administered with medications that increase their systemic

exposure, " Dr. Terry A. son from Emory University School of

Medicine notes.

He reports results from four small, short-term, parallel-group studies

looking at the pharmacokinetic interaction profiles of pravastatin,

simvastatin, and atorvastatin,

WHEN CO-ADMINISTERED in healthy adults with four CYP3A4 inhibitors:

verapamil; mibefradil; itraconazole; or clarithromycin.

Taken together, the studies demonstrate that these inhibitors " elicit

profound increases in the systemic exposures of the lipophilic statins

simvastatin and atorvastatin and their active metabolites. "

In contrast, he observes, pravastatin, which is a hydrophilic non-CYP

substrate that has no active metabolites, " exhibits a neutral

pharmacokinetic interaction profile with respect to CYP substrates. "

Earlier this month, Britain's Medicines and Healthcare Products

Regulatory Agency issued a bulletin reminding clinicians about potential

statin drug interactions.

Am J Cardiol 2004;94:1140-1146.

cappie

Greater Boston Area

T-2 10/02 9/04 A1c: 5.3

max 100 carb diet, walking, Metformin.

ALA/EPO, Coq10, B12, ALC, Vit C

Cal/mag, low dose Biotin, full spectrum E,

Policosanol, fish oil cap,

fresh flax seed, multi vitamin,

Lovastatin 20 mg, Enalapril 10 mg

12/04:143 lbs (highest weight 309),

5' tall /age 66,

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