Guest guest Posted December 23, 2004 Report Share Posted December 23, 2004 I have a section in the IgAN Notebook on www.igan.ca where I describe other kidney diseases briefly. The ones you are asking about aren't there yet, but thanks for reminding me I should add those. I would like it to be a one-stop website, eventually. In the meantime, because it's a dialysis day for me today, I won't have time to really answer your question here. But, you should be able to find these on google: FSGS - focal segmental glomerulosclerosis MPGN - Membranoproliferative glomerulonephritis But very generally, there are features that are common to many if not all glomerular kidney diseases. When they do a biopsy, they usually find a bit of everything, and it's usually one key feature that identifies the disease. For example, in the case of IgAN, it's the predominance of IgA deposits in the mesangium of glomeruli. But there could very easily also be some FSGS or MPGN features as well. And the other diseases could have some IgA deposits too, but they just aren't the predominant feature in terms of immune complex deposits. Pierre Question (as usual) > > > Hi, > > I am so sorry for asking so many questions, but I can't help it if I > don't know the answer...initially i thot i am asking too many > questions to this group and i am not sure what u all think...but > anyway i am gonna ask u again....i would like to know the difference > btw between igan ,fsgs and mgpn??? i have searched all over the net, > but couldn't find an answer...do u know any webpage that gives info > about this???? > > Thanks, > Priya > > > > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 23, 2004 Report Share Posted December 23, 2004 Pierre: Let me guess - you won the spelling bee too ;-). Pierre Lachaine wrote: I have a section in the IgAN Notebook on www.igan.ca where I describe other kidney diseases briefly. The ones you are asking about aren't there yet, but thanks for reminding me I should add those. I would like it to be a one-stop website, eventually. In the meantime, because it's a dialysis day for me today, I won't have time to really answer your question here. But, you should be able to find these on google: FSGS - focal segmental glomerulosclerosis MPGN - Membranoproliferative glomerulonephritis But very generally, there are features that are common to many if not all glomerular kidney diseases. When they do a biopsy, they usually find a bit of everything, and it's usually one key feature that identifies the disease. For example, in the case of IgAN, it's the predominance of IgA deposits in the mesangium of glomeruli. But there could very easily also be some FSGS or MPGN features as well. And the other diseases could have some IgA deposits too, but they just aren't the predominant feature in terms of immune complex deposits. Pierre Question (as usual) > > > Hi, > > I am so sorry for asking so many questions, but I can't help it if I > don't know the answer...initially i thot i am asking too many > questions to this group and i am not sure what u all think...but > anyway i am gonna ask u again....i would like to know the difference > btw between igan ,fsgs and mgpn??? i have searched all over the net, > but couldn't find an answer...do u know any webpage that gives info > about this???? > > Thanks, > Priya > > > > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 23, 2004 Report Share Posted December 23, 2004 Hi Priya, I'll take a stab at answering this one. Warning: histology is not my strong suit! IgAN and MPGN share many similarities: Both are proliferative diseases of the glomular basement membrane. They are distinguishable by looking at the patient's biopsy results and blood work. With both diseases, immune deposits are laid down on the membrane gumming up the works. With IgAN, the antibody IgA is deposited. With MPGN, C3 is deposited. MPGN is also distinguished from IgAN by exactly where in the membrane the deposition takes place and by reduplication of the basement membrane (aka " tramtracking " ). With respect to blood work, MPGN patients often have depressed C3, C4 and C3 NF - which is almost entirely unknown in IgAN patients. Lastly, IgAN is relatively common and MPGN is very rare. With both IgAN and MPGN, the damage is diffuse, meaning that it affects all of the glomeruli. Clinically, the MPGN patient and IgAN patient are similar - with the proviso that the MPGN patient tends to have higher proteinuria, worse BP problems and progresses to end stage faster. Recurrence and loss of the transplant due to the recurrence is a very real problem (with MPGN-2, something like 90% of transplant patients lose the transplanted kidney in a relatively short time because of recurrence). FSGS is a different disease entity altogether - which I don't know a whole lot about. Unlike IgAN and MPGN, the damage is focal. Only part of the glomeruli and only some of the glomeruli are scarred. It has been suggested that FSGS is on a continuum with minimal change disease. At one end of the spectrum is minimal change - which most kids outgrow. At the other end, is FSGS - which results in renal failure. Recurrence and loss of the transplanted kidney are common problems - albeit probably not as bad as with MPGN2. Depending upon severity, all three diseases are treated similarly. Thus, a patient with very aggressive IgAN will be treated as if they have FSGS or MPGN. One of my first kidney friends was the mum of an FSGS boy around 's age who (like at the time) was being treated with cyclosporine. Hope this helps. Cy Question (as usual) > > > Hi, > > I am so sorry for asking so many questions, but I can't help it if I > don't know the answer...initially i thot i am asking too many > questions to this group and i am not sure what u all think...but > anyway i am gonna ask u again....i would like to know the difference > btw between igan ,fsgs and mgpn??? i have searched all over the net, > but couldn't find an answer...do u know any webpage that gives info > about this???? > > Thanks, > Priya > > > > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 23, 2004 Report Share Posted December 23, 2004 Hi Priya, I'll take a stab at answering this one. Warning: histology is not my strong suit! IgAN and MPGN share many similarities: Both are proliferative diseases of the glomular basement membrane. They are distinguishable by looking at the patient's biopsy results and blood work. With both diseases, immune deposits are laid down on the membrane gumming up the works. With IgAN, the antibody IgA is deposited. With MPGN, C3 is deposited. MPGN is also distinguished from IgAN by exactly where in the membrane the deposition takes place and by reduplication of the basement membrane (aka " tramtracking " ). With respect to blood work, MPGN patients often have depressed C3, C4 and C3 NF - which is almost entirely unknown in IgAN patients. Lastly, IgAN is relatively common and MPGN is very rare. With both IgAN and MPGN, the damage is diffuse, meaning that it affects all of the glomeruli. Clinically, the MPGN patient and IgAN patient are similar - with the proviso that the MPGN patient tends to have higher proteinuria, worse BP problems and progresses to end stage faster. Recurrence and loss of the transplant due to the recurrence is a very real problem (with MPGN-2, something like 90% of transplant patients lose the transplanted kidney in a relatively short time because of recurrence). FSGS is a different disease entity altogether - which I don't know a whole lot about. Unlike IgAN and MPGN, the damage is focal. Only part of the glomeruli and only some of the glomeruli are scarred. It has been suggested that FSGS is on a continuum with minimal change disease. At one end of the spectrum is minimal change - which most kids outgrow. At the other end, is FSGS - which results in renal failure. Recurrence and loss of the transplanted kidney are common problems - albeit probably not as bad as with MPGN2. Depending upon severity, all three diseases are treated similarly. Thus, a patient with very aggressive IgAN will be treated as if they have FSGS or MPGN. One of my first kidney friends was the mum of an FSGS boy around 's age who (like at the time) was being treated with cyclosporine. Hope this helps. Cy Question (as usual) > > > Hi, > > I am so sorry for asking so many questions, but I can't help it if I > don't know the answer...initially i thot i am asking too many > questions to this group and i am not sure what u all think...but > anyway i am gonna ask u again....i would like to know the difference > btw between igan ,fsgs and mgpn??? i have searched all over the net, > but couldn't find an answer...do u know any webpage that gives info > about this???? > > Thanks, > Priya > > > > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 24, 2004 Report Share Posted December 24, 2004 And in both English and French : ) Pierre Re: Question (as usual) > > Pierre: > Let me guess - you won the spelling bee too ;-). > > > > Pierre Lachaine wrote: > I have a section in the IgAN Notebook on www.igan.ca where I describe other > kidney diseases briefly. The ones you are asking about aren't there yet, but > thanks for reminding me I should add those. I would like it to be a one-stop > website, eventually. In the meantime, because it's a dialysis day for me > today, I won't have time to really answer your question here. But, you > should be able to find these on google: > > FSGS - focal segmental glomerulosclerosis > MPGN - Membranoproliferative glomerulonephritis > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 24, 2004 Report Share Posted December 24, 2004 And in both English and French : ) Pierre Re: Question (as usual) > > Pierre: > Let me guess - you won the spelling bee too ;-). > > > > Pierre Lachaine wrote: > I have a section in the IgAN Notebook on www.igan.ca where I describe other > kidney diseases briefly. The ones you are asking about aren't there yet, but > thanks for reminding me I should add those. I would like it to be a one-stop > website, eventually. In the meantime, because it's a dialysis day for me > today, I won't have time to really answer your question here. But, you > should be able to find these on google: > > FSGS - focal segmental glomerulosclerosis > MPGN - Membranoproliferative glomerulonephritis > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 24, 2004 Report Share Posted December 24, 2004 And in both English and French : ) Pierre Re: Question (as usual) > > Pierre: > Let me guess - you won the spelling bee too ;-). > > > > Pierre Lachaine wrote: > I have a section in the IgAN Notebook on www.igan.ca where I describe other > kidney diseases briefly. The ones you are asking about aren't there yet, but > thanks for reminding me I should add those. I would like it to be a one-stop > website, eventually. In the meantime, because it's a dialysis day for me > today, I won't have time to really answer your question here. But, you > should be able to find these on google: > > FSGS - focal segmental glomerulosclerosis > MPGN - Membranoproliferative glomerulonephritis > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 25, 2004 Report Share Posted December 25, 2004 Fantastic job explaining the differences Cy! Thanks. In a message dated 12/23/2004 4:39:30 PM Eastern Standard Time, " Cy Webb " writes: > >Hi Priya, > >I'll take a stab at answering this one.  Warning:  histology is not my >strong suit! > >IgAN and MPGN share many similarities: Both are proliferative diseases of >the glomular basement membrane.  They are distinguishable by looking at the >patient's biopsy results and blood work.  With both diseases, immune >deposits are laid down on the membrane gumming up the works.  With IgAN, the >antibody IgA is deposited.  With MPGN, C3 is deposited.  MPGN is also >distinguished from IgAN by exactly where in the membrane the deposition >takes place  and by reduplication of the basement membrane (aka > " tramtracking " ).  With respect to blood work, MPGN patients often have >depressed C3, C4 and C3 NF - which is almost entirely unknown in IgAN >patients.  Lastly, IgAN is relatively common and MPGN is very rare. > >With both IgAN and MPGN, the damage is diffuse, meaning that it affects all >of the glomeruli.  Clinically, the MPGN patient and IgAN patient are >similar - with the proviso that the MPGN patient tends to have higher >proteinuria, worse BP problems and progresses to end stage faster. >Recurrence and loss of the transplant due to the recurrence is a very real >problem  (with MPGN-2, something like 90% of transplant patients lose the >transplanted kidney in a relatively short time because of recurrence). > >FSGS is a different disease entity altogether - which I don't know a whole >lot about.  Unlike IgAN and MPGN, the damage is focal.  Only part of the >glomeruli and only some of the glomeruli are scarred.  It has been suggested >that FSGS is on a continuum with minimal change disease.  At one end of the >spectrum is minimal change - which most kids outgrow.  At the other end, is >FSGS - which results in renal failure.  Recurrence and loss of the >transplanted kidney are common problems - albeit probably not as bad as with >MPGN2. > >Depending upon severity, all three diseases are treated similarly.  Thus, a >patient with very aggressive IgAN will be treated as if they have FSGS or >MPGN.  One of my first kidney friends was the mum of an FSGS boy around >'s age who (like at the time) was being treated with >cyclosporine. > >Hope this helps. > >Cy > Question (as usual) > > >> >> >> Hi, >> >> I am so sorry for asking so many questions, but I can't help it if I >> don't know the answer...initially i thot i am asking too many >> questions to this group and i am not sure what u all think...but >> anyway i am gonna ask u again....i would like to know the difference >> btw between igan ,fsgs and mgpn??? i have searched all over the net, >> but couldn't find an answer...do u know any webpage that gives info >> about this???? >> >> Thanks, >> Priya >> >> >> >> >> >> >> To edit your settings for the group, go to our Yahoo Group >> home page: >> http://groups.yahoo.com/group/iga-nephropathy/ >> >> To unsubcribe via email, >> iga-nephropathy-unsubscribe >> Visit our companion website at www.igan.ca. The site is entirely supported >by donations. If you would like to help, go to: >> http://www.igan.ca/id62.htm >> >> Thank you >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 25, 2004 Report Share Posted December 25, 2004 Fantastic job explaining the differences Cy! Thanks. In a message dated 12/23/2004 4:39:30 PM Eastern Standard Time, " Cy Webb " writes: > >Hi Priya, > >I'll take a stab at answering this one.  Warning:  histology is not my >strong suit! > >IgAN and MPGN share many similarities: Both are proliferative diseases of >the glomular basement membrane.  They are distinguishable by looking at the >patient's biopsy results and blood work.  With both diseases, immune >deposits are laid down on the membrane gumming up the works.  With IgAN, the >antibody IgA is deposited.  With MPGN, C3 is deposited.  MPGN is also >distinguished from IgAN by exactly where in the membrane the deposition >takes place  and by reduplication of the basement membrane (aka > " tramtracking " ).  With respect to blood work, MPGN patients often have >depressed C3, C4 and C3 NF - which is almost entirely unknown in IgAN >patients.  Lastly, IgAN is relatively common and MPGN is very rare. > >With both IgAN and MPGN, the damage is diffuse, meaning that it affects all >of the glomeruli.  Clinically, the MPGN patient and IgAN patient are >similar - with the proviso that the MPGN patient tends to have higher >proteinuria, worse BP problems and progresses to end stage faster. >Recurrence and loss of the transplant due to the recurrence is a very real >problem  (with MPGN-2, something like 90% of transplant patients lose the >transplanted kidney in a relatively short time because of recurrence). > >FSGS is a different disease entity altogether - which I don't know a whole >lot about.  Unlike IgAN and MPGN, the damage is focal.  Only part of the >glomeruli and only some of the glomeruli are scarred.  It has been suggested >that FSGS is on a continuum with minimal change disease.  At one end of the >spectrum is minimal change - which most kids outgrow.  At the other end, is >FSGS - which results in renal failure.  Recurrence and loss of the >transplanted kidney are common problems - albeit probably not as bad as with >MPGN2. > >Depending upon severity, all three diseases are treated similarly.  Thus, a >patient with very aggressive IgAN will be treated as if they have FSGS or >MPGN.  One of my first kidney friends was the mum of an FSGS boy around >'s age who (like at the time) was being treated with >cyclosporine. > >Hope this helps. > >Cy > Question (as usual) > > >> >> >> Hi, >> >> I am so sorry for asking so many questions, but I can't help it if I >> don't know the answer...initially i thot i am asking too many >> questions to this group and i am not sure what u all think...but >> anyway i am gonna ask u again....i would like to know the difference >> btw between igan ,fsgs and mgpn??? i have searched all over the net, >> but couldn't find an answer...do u know any webpage that gives info >> about this???? >> >> Thanks, >> Priya >> >> >> >> >> >> >> To edit your settings for the group, go to our Yahoo Group >> home page: >> http://groups.yahoo.com/group/iga-nephropathy/ >> >> To unsubcribe via email, >> iga-nephropathy-unsubscribe >> Visit our companion website at www.igan.ca. The site is entirely supported >by donations. If you would like to help, go to: >> http://www.igan.ca/id62.htm >> >> Thank you >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 25, 2004 Report Share Posted December 25, 2004 Fantastic job explaining the differences Cy! Thanks. In a message dated 12/23/2004 4:39:30 PM Eastern Standard Time, " Cy Webb " writes: > >Hi Priya, > >I'll take a stab at answering this one.  Warning:  histology is not my >strong suit! > >IgAN and MPGN share many similarities: Both are proliferative diseases of >the glomular basement membrane.  They are distinguishable by looking at the >patient's biopsy results and blood work.  With both diseases, immune >deposits are laid down on the membrane gumming up the works.  With IgAN, the >antibody IgA is deposited.  With MPGN, C3 is deposited.  MPGN is also >distinguished from IgAN by exactly where in the membrane the deposition >takes place  and by reduplication of the basement membrane (aka > " tramtracking " ).  With respect to blood work, MPGN patients often have >depressed C3, C4 and C3 NF - which is almost entirely unknown in IgAN >patients.  Lastly, IgAN is relatively common and MPGN is very rare. > >With both IgAN and MPGN, the damage is diffuse, meaning that it affects all >of the glomeruli.  Clinically, the MPGN patient and IgAN patient are >similar - with the proviso that the MPGN patient tends to have higher >proteinuria, worse BP problems and progresses to end stage faster. >Recurrence and loss of the transplant due to the recurrence is a very real >problem  (with MPGN-2, something like 90% of transplant patients lose the >transplanted kidney in a relatively short time because of recurrence). > >FSGS is a different disease entity altogether - which I don't know a whole >lot about.  Unlike IgAN and MPGN, the damage is focal.  Only part of the >glomeruli and only some of the glomeruli are scarred.  It has been suggested >that FSGS is on a continuum with minimal change disease.  At one end of the >spectrum is minimal change - which most kids outgrow.  At the other end, is >FSGS - which results in renal failure.  Recurrence and loss of the >transplanted kidney are common problems - albeit probably not as bad as with >MPGN2. > >Depending upon severity, all three diseases are treated similarly.  Thus, a >patient with very aggressive IgAN will be treated as if they have FSGS or >MPGN.  One of my first kidney friends was the mum of an FSGS boy around >'s age who (like at the time) was being treated with >cyclosporine. > >Hope this helps. > >Cy > Question (as usual) > > >> >> >> Hi, >> >> I am so sorry for asking so many questions, but I can't help it if I >> don't know the answer...initially i thot i am asking too many >> questions to this group and i am not sure what u all think...but >> anyway i am gonna ask u again....i would like to know the difference >> btw between igan ,fsgs and mgpn??? i have searched all over the net, >> but couldn't find an answer...do u know any webpage that gives info >> about this???? >> >> Thanks, >> Priya >> >> >> >> >> >> >> To edit your settings for the group, go to our Yahoo Group >> home page: >> http://groups.yahoo.com/group/iga-nephropathy/ >> >> To unsubcribe via email, >> iga-nephropathy-unsubscribe >> Visit our companion website at www.igan.ca. The site is entirely supported >by donations. If you would like to help, go to: >> http://www.igan.ca/id62.htm >> >> Thank you >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 25, 2004 Report Share Posted December 25, 2004 Thanks . I still like to think Pierre has the final line " It doesn't matter which horse you rode in on... " ! Cy Question (as usual) > > > > > >> > >> > >> Hi, > >> > >> I am so sorry for asking so many questions, but I can't help it if I > >> don't know the answer...initially i thot i am asking too many > >> questions to this group and i am not sure what u all think...but > >> anyway i am gonna ask u again....i would like to know the difference > >> btw between igan ,fsgs and mgpn??? i have searched all over the net, > >> but couldn't find an answer...do u know any webpage that gives info > >> about this???? > >> > >> Thanks, > >> Priya > >> > >> > >> > >> > >> > >> > >> To edit your settings for the group, go to our Yahoo Group > >> home page: > >> http://groups.yahoo.com/group/iga-nephropathy/ > >> > >> To unsubcribe via email, > >> iga-nephropathy-unsubscribe > >> Visit our companion website at www.igan.ca. The site is entirely supported > >by donations. If you would like to help, go to: > >> http://www.igan.ca/id62.htm > >> > >> Thank you > >> Quote Link to comment Share on other sites More sharing options...
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