ANGIOTENSIN II RECEPTOR together with ACE INHIBITORS???

[Guest guest]

My neprho has just added AVAPRO (Angiotensin II receptor

antagonists) to my medications because he is saying that there have

been studies with good results when you combine that with ACE

inhibitors. Has anyone heard about his, too?

I was diagnosed 8 years ago has been stable except that my protein

loss is slightly unstable the last 2 years. I'm about at 2000.

He is saying that with this new med we may be able to reduce the

protein loss....

- diagnosed 1996

- meds: ace inhibitor, dipyridamole and fish oild therapy

- 58% clearance, 2.1 creatinine, 2000 protienuria

[Guest guest]

Yes, there have been some studies, and there are many people who are

prescribed both an ACE inhibitor and an ARB in hopes that both will be more

effective than either alone. We have had some on this group.

There's some debate as to whether this is really better than just boosting

the ACE inhibitor alone to the highest dose possible, but it certainly is an

increasinly common option to try over the past couple of years.

Pierre

ANGIOTENSIN II RECEPTOR together with ACE INHIBITORS???

>

>

>

>

> My neprho has just added AVAPRO (Angiotensin II receptor

> antagonists) to my medications because he is saying that there have

> been studies with good results when you combine that with ACE

> inhibitors. Has anyone heard about his, too?

>

> I was diagnosed 8 years ago has been stable except that my protein

> loss is slightly unstable the last 2 years. I'm about at 2000.

>

> He is saying that with this new med we may be able to reduce the

> protein loss....

>

>

> - diagnosed 1996

> - meds: ace inhibitor, dipyridamole and fish oild therapy

> - 58% clearance, 2.1 creatinine, 2000 protienuria

>

>

[Guest guest]

Thanks a lot for the response. I will start taking ARB together with

ACE, hopefully it will reduce my protein loss.

My concern is: is there a known long term side effect for this

combo?...i had been taking ACE for 8 years and had been happy with

it..i'm just wondering if anyone here has been taking the combo for

a long period of time and if i can get a feedback.

also, should the nephro have reduced the ACE dosage if i will take

another BP med?

i appreciate your help!

> Yes, there have been some studies, and there are many people who

are

> prescribed both an ACE inhibitor and an ARB in hopes that both

will be more

> effective than either alone. We have had some on this group.

>

> There's some debate as to whether this is really better than just

boosting

> the ACE inhibitor alone to the highest dose possible, but it

certainly is an

> increasinly common option to try over the past couple of years.

>

> Pierre

>

>

> ANGIOTENSIN II RECEPTOR together with ACE

INHIBITORS???

>

>

> >

> >

> >

> >

> > My neprho has just added AVAPRO (Angiotensin II receptor

> > antagonists) to my medications because he is saying that there

have

> > been studies with good results when you combine that with ACE

> > inhibitors. Has anyone heard about his, too?

> >

> > I was diagnosed 8 years ago has been stable except that my

protein

> > loss is slightly unstable the last 2 years. I'm about at 2000.

> >

> > He is saying that with this new med we may be able to reduce the

> > protein loss....

> >

> >

> > - diagnosed 1996

> > - meds: ace inhibitor, dipyridamole and fish oild therapy

> > - 58% clearance, 2.1 creatinine, 2000 protienuria

> >

> >

[Guest guest]

I've heard good thngs about the Ace inhibitor/angiotensin II receptor

blocker combination. I did some library research on this question when the

docs were going to put on this combination. I've included an

abstract that I found on this question (see below). Although the number of

patients in the this study is quite small, similar results were found in

larger studies of adult diabetics. This tentatively suggests that the

combination can reduce severe proteinuria.

Cy

Combined therapy of enalapril and losartan attenuates histologic progression

in immunoglobulin A nephropathy.

Tanaka H, Suzuki K, Nakahata T, Tsugawa K, Konno Y, Tsuruga K, Ito E, Waga

S.

Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki,

Japan. hirotana@...

BACKGROUND: It has been reported that combined therapy of angiotensin

converting enzyme inhibitor and angiotensin receptor blocker significantly

decreases proteinuria in immunoglobulin A (IgA) nephropathy. However,

histologic alterations following the therapy have not been reported.

METHODS: A total of nine Japanese children with severe proteinuric IgA

nephropathy who received a prompt immunosuppressive therapy were enrolled

the study, four of whom received a combined therapy of angiotensin

converting enzyme inhibitor, enalapril and angiotensin receptor blocker,

losartan (Group A), while the remaining five did not (Group . All

underwent renal biopsy before and approximately 12 months after the first

renal biopsy. RESULTS: At presentation, urine protein excretion and the

histologic indices of mean activity index, mean chronicity index and

tubulointerstitial scores did not show a statistical difference between the

two groups: Group A (2.6 +/- 0.6 g/day; mean activity index, 5.0 +/- 1.0;

mean chronicity index, 5.0 +/- 1.0; tubulointerstitial scores, 4.3 +/- 1.0)

and Group B (2.2 +/- 0.6 g/day; mean activity index, 4.8 +/- 0.8; mean

chronicity index, 4.8 +/- 1.3; tubulointerstitial scores, 3.6 +/- 0.5,

respectively). All had normal blood pressure and renal function. Urine

protein excretion and the activity index decreased at the second renal

biopsy, while the chronicity index and the tubulointerstitial scores

slightly increased or remained unchanged. In comparison with Group B, a

significant suppression in increasing the chronicity index and the

tubulointerstitial scores obtained at the second renal biopsy were observed

in Group A [Group A: 4.3 +/- 1.2 and 3.0 +/- 0.0, respectively, vs Group B:

6.0 +/- 0.7 and 4.4 +/- 0.9, respectively (P < 0.05)]. One patient in Group

B developed chronic renal insufficiency thereafter. CONCLUSIONS: Although

only a small number of patients were examined, these clinical findings

suggest that a combined therapy of enalapril and losartan may attenuate

histologic progression in at least a proportion of patients with severe

proteinuric IgA nephropathy.

ANGIOTENSIN II RECEPTOR together with ACE INHIBITORS???

>

>

>

>

> My neprho has just added AVAPRO (Angiotensin II receptor

> antagonists) to my medications because he is saying that there have

> been studies with good results when you combine that with ACE

> inhibitors. Has anyone heard about his, too?

>

> I was diagnosed 8 years ago has been stable except that my protein

> loss is slightly unstable the last 2 years. I'm about at 2000.

>

> He is saying that with this new med we may be able to reduce the

> protein loss....

>

>

> - diagnosed 1996

> - meds: ace inhibitor, dipyridamole and fish oild therapy

> - 58% clearance, 2.1 creatinine, 2000 protienuria

>

>

>

>

>

>

>

>

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

>

> To unsubcribe via email,

> iga-nephropathy-unsubscribe

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

[Guest guest]

I've heard good thngs about the Ace inhibitor/angiotensin II receptor

blocker combination. I did some library research on this question when the

docs were going to put on this combination. I've included an

abstract that I found on this question (see below). Although the number of

patients in the this study is quite small, similar results were found in

larger studies of adult diabetics. This tentatively suggests that the

combination can reduce severe proteinuria.

Cy

Combined therapy of enalapril and losartan attenuates histologic progression

in immunoglobulin A nephropathy.

Tanaka H, Suzuki K, Nakahata T, Tsugawa K, Konno Y, Tsuruga K, Ito E, Waga

S.

Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki,

Japan. hirotana@...

BACKGROUND: It has been reported that combined therapy of angiotensin

converting enzyme inhibitor and angiotensin receptor blocker significantly

decreases proteinuria in immunoglobulin A (IgA) nephropathy. However,

histologic alterations following the therapy have not been reported.

METHODS: A total of nine Japanese children with severe proteinuric IgA

nephropathy who received a prompt immunosuppressive therapy were enrolled

the study, four of whom received a combined therapy of angiotensin

converting enzyme inhibitor, enalapril and angiotensin receptor blocker,

losartan (Group A), while the remaining five did not (Group . All

underwent renal biopsy before and approximately 12 months after the first

renal biopsy. RESULTS: At presentation, urine protein excretion and the

histologic indices of mean activity index, mean chronicity index and

tubulointerstitial scores did not show a statistical difference between the

two groups: Group A (2.6 +/- 0.6 g/day; mean activity index, 5.0 +/- 1.0;

mean chronicity index, 5.0 +/- 1.0; tubulointerstitial scores, 4.3 +/- 1.0)

and Group B (2.2 +/- 0.6 g/day; mean activity index, 4.8 +/- 0.8; mean

chronicity index, 4.8 +/- 1.3; tubulointerstitial scores, 3.6 +/- 0.5,

respectively). All had normal blood pressure and renal function. Urine

protein excretion and the activity index decreased at the second renal

biopsy, while the chronicity index and the tubulointerstitial scores

slightly increased or remained unchanged. In comparison with Group B, a

significant suppression in increasing the chronicity index and the

tubulointerstitial scores obtained at the second renal biopsy were observed

in Group A [Group A: 4.3 +/- 1.2 and 3.0 +/- 0.0, respectively, vs Group B:

6.0 +/- 0.7 and 4.4 +/- 0.9, respectively (P < 0.05)]. One patient in Group

B developed chronic renal insufficiency thereafter. CONCLUSIONS: Although

only a small number of patients were examined, these clinical findings

suggest that a combined therapy of enalapril and losartan may attenuate

histologic progression in at least a proportion of patients with severe

proteinuric IgA nephropathy.

ANGIOTENSIN II RECEPTOR together with ACE INHIBITORS???

>

>

>

>

> My neprho has just added AVAPRO (Angiotensin II receptor

> antagonists) to my medications because he is saying that there have

> been studies with good results when you combine that with ACE

> inhibitors. Has anyone heard about his, too?

>

> I was diagnosed 8 years ago has been stable except that my protein

> loss is slightly unstable the last 2 years. I'm about at 2000.

>

> He is saying that with this new med we may be able to reduce the

> protein loss....

>

>

> - diagnosed 1996

> - meds: ace inhibitor, dipyridamole and fish oild therapy

> - 58% clearance, 2.1 creatinine, 2000 protienuria

>

>

>

>

>

>

>

>

>

>

> To edit your settings for the group, go to our Yahoo Group

> home page:

> http://groups.yahoo.com/group/iga-nephropathy/

>

> To unsubcribe via email,

> iga-nephropathy-unsubscribe

> Visit our companion website at www.igan.ca. The site is entirely supported

by donations. If you would like to help, go to:

> http://www.igan.ca/id62.htm

>

> Thank you

>

[Guest guest]

Hi na,

That is great news that you have no proteinuria and no hematuria! I am

rejoicing with you :-)

Keep up the great results.

In a message dated 1/10/2005 3:05:29 PM Pacific Standard Time,

farizada_mardel@... writes:

> Hi Leo, How are you? I hope fine.

> I'm taking 5 mg/day of Enalapril and 25 mg/day of Losartan, since my

> biopsy in August, when I had 1 g/24 hs of proteinuria. After a month

> of treatment I had no proteinuria, and in my last control in

> December, there was still no proteinuria and also no hematuria.

> The dosis I'm taking it's very low, almost nothing. I have normal

> renal function.

> I hope this numbers can help you. As you can see, I haven't taken

> them a long period to tell you if there's some side effect, so far

> so good.I'll tell you in my next control in March what happened.

> I forgot my brother has been also taking this medicines for 2 years,

> he's at 50% of renal function, and he's doing fine, he takes 10 mg

> of enalapril, and 25 mg of losartan, but he has to be careful,

> because this medicines can raise creatinine in people with a lost of

> function.

> Kisses, and stay in contact.

> na

[Guest guest]

Hi Leo, How are you? I hope fine.

I'm taking 5 mg/day of Enalapril and 25 mg/day of Losartan, since my

biopsy in August, when I had 1 g/24 hs of proteinuria. After a month

of treatment I had no proteinuria, and in my last control in

December, there was still no proteinuria and also no hematuria.

The dosis I'm taking it's very low, almost nothing. I have normal

renal function.

I hope this numbers can help you. As you can see, I haven't taken

them a long period to tell you if there's some side effect, so far

so good.I'll tell you in my next control in March what happened.

I forgot my brother has been also taking this medicines for 2 years,

he's at 50% of renal function, and he's doing fine, he takes 10 mg

of enalapril, and 25 mg of losartan, but he has to be careful,

because this medicines can raise creatinine in people with a lost of

function.

Kisses, and stay in contact.

na

> > Yes, there have been some studies, and there are many people who

> are

> > prescribed both an ACE inhibitor and an ARB in hopes that both

> will be more

> > effective than either alone. We have had some on this group.

> >

> > There's some debate as to whether this is really better than

just

> boosting

> > the ACE inhibitor alone to the highest dose possible, but it

> certainly is an

> > increasinly common option to try over the past couple of years.

> >

> > Pierre

> >

> >

> > ANGIOTENSIN II RECEPTOR together with ACE

> INHIBITORS???

> >

> >

> > >

> > >

> > >

> > >

> > > My neprho has just added AVAPRO (Angiotensin II receptor

> > > antagonists) to my medications because he is saying that there

> have

> > > been studies with good results when you combine that with ACE

> > > inhibitors. Has anyone heard about his, too?

> > >

> > > I was diagnosed 8 years ago has been stable except that my

> protein

> > > loss is slightly unstable the last 2 years. I'm about at 2000.

> > >

> > > He is saying that with this new med we may be able to reduce

the

> > > protein loss....

> > >

> > >

> > > - diagnosed 1996

> > > - meds: ace inhibitor, dipyridamole and fish oild therapy

> > > - 58% clearance, 2.1 creatinine, 2000 protienuria

> > >

> > >

[Guest guest]

Hi Leo, How are you? I hope fine.

I'm taking 5 mg/day of Enalapril and 25 mg/day of Losartan, since my

biopsy in August, when I had 1 g/24 hs of proteinuria. After a month

of treatment I had no proteinuria, and in my last control in

December, there was still no proteinuria and also no hematuria.

The dosis I'm taking it's very low, almost nothing. I have normal

renal function.

I hope this numbers can help you. As you can see, I haven't taken

them a long period to tell you if there's some side effect, so far

so good.I'll tell you in my next control in March what happened.

I forgot my brother has been also taking this medicines for 2 years,

he's at 50% of renal function, and he's doing fine, he takes 10 mg

of enalapril, and 25 mg of losartan, but he has to be careful,

because this medicines can raise creatinine in people with a lost of

function.

Kisses, and stay in contact.

na

> > Yes, there have been some studies, and there are many people who

> are

> > prescribed both an ACE inhibitor and an ARB in hopes that both

> will be more

> > effective than either alone. We have had some on this group.

> >

> > There's some debate as to whether this is really better than

just

> boosting

> > the ACE inhibitor alone to the highest dose possible, but it

> certainly is an

> > increasinly common option to try over the past couple of years.

> >

> > Pierre

> >

> >

> > ANGIOTENSIN II RECEPTOR together with ACE

> INHIBITORS???

> >

> >

> > >

> > >

> > >

> > >

> > > My neprho has just added AVAPRO (Angiotensin II receptor

> > > antagonists) to my medications because he is saying that there

> have

> > > been studies with good results when you combine that with ACE

> > > inhibitors. Has anyone heard about his, too?

> > >

> > > I was diagnosed 8 years ago has been stable except that my

> protein

> > > loss is slightly unstable the last 2 years. I'm about at 2000.

> > >

> > > He is saying that with this new med we may be able to reduce

the

> > > protein loss....

> > >

> > >

> > > - diagnosed 1996

> > > - meds: ace inhibitor, dipyridamole and fish oild therapy

> > > - 58% clearance, 2.1 creatinine, 2000 protienuria

> > >

> > >

[Guest guest]

Hi Leo, How are you? I hope fine.

I'm taking 5 mg/day of Enalapril and 25 mg/day of Losartan, since my

biopsy in August, when I had 1 g/24 hs of proteinuria. After a month

of treatment I had no proteinuria, and in my last control in

December, there was still no proteinuria and also no hematuria.

The dosis I'm taking it's very low, almost nothing. I have normal

renal function.

I hope this numbers can help you. As you can see, I haven't taken

them a long period to tell you if there's some side effect, so far

so good.I'll tell you in my next control in March what happened.

I forgot my brother has been also taking this medicines for 2 years,

he's at 50% of renal function, and he's doing fine, he takes 10 mg

of enalapril, and 25 mg of losartan, but he has to be careful,

because this medicines can raise creatinine in people with a lost of

function.

Kisses, and stay in contact.

na

> > Yes, there have been some studies, and there are many people who

> are

> > prescribed both an ACE inhibitor and an ARB in hopes that both

> will be more

> > effective than either alone. We have had some on this group.

> >

> > There's some debate as to whether this is really better than

just

> boosting

> > the ACE inhibitor alone to the highest dose possible, but it

> certainly is an

> > increasinly common option to try over the past couple of years.

> >

> > Pierre

> >

> >

> > ANGIOTENSIN II RECEPTOR together with ACE

> INHIBITORS???

> >

> >

> > >

> > >

> > >

> > >

> > > My neprho has just added AVAPRO (Angiotensin II receptor

> > > antagonists) to my medications because he is saying that there

> have

> > > been studies with good results when you combine that with ACE

> > > inhibitors. Has anyone heard about his, too?

> > >

> > > I was diagnosed 8 years ago has been stable except that my

> protein

> > > loss is slightly unstable the last 2 years. I'm about at 2000.

> > >

> > > He is saying that with this new med we may be able to reduce

the

> > > protein loss....

> > >

> > >

> > > - diagnosed 1996

> > > - meds: ace inhibitor, dipyridamole and fish oild therapy

> > > - 58% clearance, 2.1 creatinine, 2000 protienuria

> > >

> > >