Investigating New Vaccines: Ebola and HIV

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Molecular Medicine MedPulse

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________________________ NEW FEATURES THIS WEEK ________________________

Conference Report - I. Investigating New Vaccines: Ebola and HIV

An overview of the latest advances in epidemiology and vaccine design

for Ebola and HIV infections.

Medscape General Medicine 5(4) 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQi0Ap

Fatal Disseminated Adenovirus Infections in Immunocompromised Patients

Clinicians and pathologists must be aware of the pathogenicity of

adenovirus in these patients, including its potential for causing

life-threatening hemorrhage.

Am J Clin Pathol 120(4) 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQj0Aq

Cell Therapies for Inherited Myopathies

Cell therapies offer two complementary actions: they can deliver normal

genomes to myofibers, and they can potentially increase the myogenic

capital of wasted muscles.

Curr Opin Rheumatol 15(6) 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQk0Ar

Factors Associated With Ipsilateral Breast Failure and Distant

Metastases in Patients With Invasive Breast Carcinoma

Invasive breast carcinoma treated with breast-conserving therapy has

been studied extensively during the past several decades.

Am J Clin Pathol 120(4) 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQl0As

FOCUS ON SEPSIS

The seriousness of sepsis, both in terms of cost and loss of quality

of life, presents a challenge. Data show that the annual incidence of

severe sepsis is on the order of over 18 million cases worldwide each

year. Keep pace with the most current information on this devastating

condition on Medscape's Sepsis Resource Center.

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FMNy0AW

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_________________________________ NEWS _________________________________

Neurogenesis Is Increased in Brains of Patients With Alzheimer Disease

Hippocampal neurogenesis seems to be accelerated in brains affected by

Alzheimer disease (AD), even though progressive cell loss also occurs,

according to a new report.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQm0At

Brain Arterial Atherosclerosis Associated With Alzheimer's Disease

Circle of Willis atherosclerosis appears to be a risk factor for

sporadic Alzheimer's disease (AD), an autopsy study indicates.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQn0Au

Host Genotype Plays Important Role in Childhood HIV Progression

In children, CCR5 genotype and other host genetic factors play an

important role in HIV-related disease progression and neurological

impairment, according to a report in the November 15th issue of The

Journal of Infectious Diseases.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQo0Av

Umbilical Cord Blood Therapy Heals Persistent Corneal Epithelial Defects

Umbilical cord serum therapy promotes healing of persistent corneal

epithelial defects that are not amenable to routine medical treatment,

results of a controlled trial suggest.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQp0Aw

EU to Fund Stem Cell Research Despite Ethics Split

The European Commission will fund controversial research using stem

cells harvested from human embryos, despite the failure of EU ministers

to agree on ethical guidelines, a commissioner said on Wednesday.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQq0Ax

Bid Set to Revive UN Ban on Stem Cell Research

A bloc of 40 countries has decided to try to overturn a recent U.N. vote

and revive work on a global treaty that would ban medical research on

stem cells, diplomats said on Wednesday.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQr0Ay

Gene Methylation Determination May Help Stratify Smokers' Cancer Risk

Aberrant methylation of genes in the upper aerodigestive tract of heavy

smokers may be a marker of high lung cancer risk, researchers report in

the November issue of the International Journal of Cancer.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQs0Az

New Polymorphisms Identified in IL4 Gene, Many Linked to Asthma

German and US researchers have identified 14 new polymorphisms in the

interleukin (IL)-4 gene and at least 10 seem to be associated with

asthma and elevated IgE levels.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQt0A1

Parents Psychologically Unscathed After Identification of Newborn CF

rs

The biggest hurdle these parents face appears to be the need to discuss

the findings with family members.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQu0A2

Interleukin-10 Genotype Predicts Risk of Graft-Versus-Host Disease

Recipients of hematopoietic cells from an HLA-identical sibling who have

the IL10 -592A allele are at lower risk of GVHD after hematopoietic

stem-cell transplant.

Medscape Medical News 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQv0A3

Yeast Cells May Provide Insight Into Degenerative Neurologic Diseases

In two new studies reported in the December 5th issue of Science,

researchers used yeast cells to investigate how alpha-synuclein and

other proteins may contribute to the pathogenesis of degenerative

neurologic disorders, such as Huntington's disease.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQw0A4

Genetic Polymorphism Influences C-Reactive Protein Levels

A polymorphism designated +1444C>T in the C-reactive protein (CRP) gene

influences CRP levels, according to a new study.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQx0A5

Microbeam Irradiation Destroys Many Cancer Cells by Bystander Effect

Targeting cancer cells with a microbeam of radioactive particles

destroys many more cells than those in the path of the beam, paving the

way for possible advances in radiotherapy, scientists said on Monday.

Reuters Health Information 2003

http://mp.medscape.com/cgi-bin1/DM/y/eefx0EYg440D160FmQy0A6

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