grapefruit/HC interaction possible

[Guest guest]

Again, from checkmymeds.com

> MONITOR: Grapefruit juice may increase the plasma concentrations of

> some orally administered drugs that are substrates of the CYP450 3A4

> isoenzyme. The proposed mechanism is inhibition of CYP450 3A4-mediated

> first-pass metabolism in the gut wall by certain compounds present in

> grapefruits. The extent and clinical significance are unknown.

> Moreover, pharmacokinetic alterations associated with interactions

> involving grapefruit juice are often subject to a high degree of

> interpatient variability. MANAGEMENT: Patients who regularly consume

> grapefruits and grapefruit juice should be monitored for adverse

> effects and altered plasma concentrations of drugs that are

> metabolized by CYP450 3A4. Grapefruits and grapefruit juice should be

> avoided if an interaction is suspected. Orange juice is not expected

> to interact with these drugs.

It really is amazing how often this grapefruit/grapefruit juice

interaction comes up with all sorts of meds.

sol