NIH study- POTS

[Guest guest]

If you have any other referrals

with POTs please give them my number.

thanks

Rita Mincemoyer RN

Protocol 98-H-0029: Study of Vascular responsiveness in subjects with

polymorphisms of the Angiotensin II type I receptor gene.

The purpose of this study is to determine if differences in a number of

inherited proteins influence an individual's tendency to develop

symptoms

associated with blood pressure changes while standing. It is possible

that

symptoms of lightheadedness, dizziness, or passing out are related to

changes in blood pressure and the body's response to these changes.

Angiotensin II is a hormone that circulates in the blood stream and

makes

blood vessels constrict (become narrow), thereby having an effect on

blood

pressure. It does this by attaching to a protein on the blood vessels.

We

have found that different people have different forms of this protein

that

attaches to the blood vessel. The study involves analysis of DNA (from

blood sample) for differences in the gene that makes this protein, When

we

have looked at this gene in many people we will see whether these

differences have any effect on the body's regulation of blood pressure.

Two tubes of blood (one tablespoon) will be taken from you for this

study in

order to obtain a supply of DNA with which to perform the analysis. The

blood samples will be stored indefinitely at the NIH. They may be used

for

further studies related to heart disease. They may be shared with other

researchers who are doing research related to heart disease but only

after

your name and all identifying information is removed.

This study may increase our understanding of the causes and symptoms of

low

blood pressure and of heart disease. Although there may be no direct

benefit to you, it is our belief that continued research into the cause

of

these conditions will provide information that will help direct

diagnosis

and treatment.

Address and Contact Information:

Rita Mincemoyer RN

Research Nurse

National Institutes of Health

NHLBI Cardiology Branch

Bldg.10 Rm. 7B-15

Bethesda, MD 20892-1650

Telephone:

FAX:

e-mail: mincemor@...