Re: New drug for emotional lability

[Guest guest]

WOW how fantastic to have a drug for this very troublesome side

effect!! For me, the crying is the worst. I will cry when i am

feeling just a teensy weensy bit emotional. Its very irritating and

embarassing. The sooner they get this drug out the better. I hope it

will be approved in Australia.

Maureen in Sydney

> Avanir Says Investigational Drug Curbs MS Laughing,

> Crying Episodes

>

>

> NEW YORK (Reuters) Aug 24 - Avanir Pharmaceuticals on

> Tuesday said its experimental drug for emotional

> lability, Neurodex (dextromethorphan, quinidine),

> successfully controlled a symptom of uncontrollable

> laughter or crying in a late-stage trial of patients

> with multiple sclerosis.

> The San Diego-based company said the phase III trial

> involved 150 patients at 22 medical centers, some of

> whom received Neurodex for 90 days, while others

> received placebos.

> It said patients receiving Neurodex had a

> statistically significant greater reduction in

> frequency and severity of episodes than those

> receiving placebos, the main goal of the trial.

> Moreover, they had uniformly better outcomes in

> secondary goals such as quality of life and pain

> reduction, the company said in a release.

> Neurodex was well tolerated in the trial, with the

> majority of patients reporting mild or moderate side

> effects such as dizziness.

> Avanir said uncontrollable laughing or crying --

> pseudobulbar affect -- can also affect patients with

> amyotrophic lateral sclerosis, Alzheimer's disease,

> stroke and traumatic brain injury.

> The favorable results seen in the study of patients

> with multiple sclerosis were similar to those seen in

> a previous trial of patients with ALS, the company

> said.

> " Through the treatment of pseudobulbar affect, we can

> eliminate or reduce patients' anxiety about

> controlling their emotions in social and business

> settings, thus improving their quality of life, " the

> company said.

> Avanir said plans to seek marketing approval of

> Neurodex based upon favorable results of its two

> late-stage trials.

[Guest guest]

WOW how fantastic to have a drug for this very troublesome side

effect!! For me, the crying is the worst. I will cry when i am

feeling just a teensy weensy bit emotional. Its very irritating and

embarassing. The sooner they get this drug out the better. I hope it

will be approved in Australia.

Maureen in Sydney

> Avanir Says Investigational Drug Curbs MS Laughing,

> Crying Episodes

>

>

> NEW YORK (Reuters) Aug 24 - Avanir Pharmaceuticals on

> Tuesday said its experimental drug for emotional

> lability, Neurodex (dextromethorphan, quinidine),

> successfully controlled a symptom of uncontrollable

> laughter or crying in a late-stage trial of patients

> with multiple sclerosis.

> The San Diego-based company said the phase III trial

> involved 150 patients at 22 medical centers, some of

> whom received Neurodex for 90 days, while others

> received placebos.

> It said patients receiving Neurodex had a

> statistically significant greater reduction in

> frequency and severity of episodes than those

> receiving placebos, the main goal of the trial.

> Moreover, they had uniformly better outcomes in

> secondary goals such as quality of life and pain

> reduction, the company said in a release.

> Neurodex was well tolerated in the trial, with the

> majority of patients reporting mild or moderate side

> effects such as dizziness.

> Avanir said uncontrollable laughing or crying --

> pseudobulbar affect -- can also affect patients with

> amyotrophic lateral sclerosis, Alzheimer's disease,

> stroke and traumatic brain injury.

> The favorable results seen in the study of patients

> with multiple sclerosis were similar to those seen in

> a previous trial of patients with ALS, the company

> said.

> " Through the treatment of pseudobulbar affect, we can

> eliminate or reduce patients' anxiety about

> controlling their emotions in social and business

> settings, thus improving their quality of life, " the

> company said.

> Avanir said plans to seek marketing approval of

> Neurodex based upon favorable results of its two

> late-stage trials.

[Guest guest]

Maureen, I take Celexa for the crying. Originally I started taking it for

anxiety attacks I was having before dx and I was falling so much. Every time I

fell I would cry so much people thought I was dying when I wasn't even hurt.

Also, everytime I visited the doctor I cried so much she talked me into it (I

didn't want to take anything). Anyway the Celexa helped with the anxiety

attacks and with the crying. Also helped with the laughing although I still

have laughing attacks but not as often. Susieq in Calif

Maureen wrote:For me, the crying is the worst. I

will cry when i am

feeling just a teensy weensy bit emotional. Its very irritating and

embarassing.

[Guest guest]

Maureen, I take Celexa for the crying. Originally I started taking it for

anxiety attacks I was having before dx and I was falling so much. Every time I

fell I would cry so much people thought I was dying when I wasn't even hurt.

Also, everytime I visited the doctor I cried so much she talked me into it (I

didn't want to take anything). Anyway the Celexa helped with the anxiety

attacks and with the crying. Also helped with the laughing although I still

have laughing attacks but not as often. Susieq in Calif

Maureen wrote:For me, the crying is the worst. I

will cry when i am

feeling just a teensy weensy bit emotional. Its very irritating and

embarassing.

[Guest guest]

The celexa also helps me with the crying jags. I wouldn't be

without it.