Guest guest Posted March 7, 2000 Report Share Posted March 7, 2000 hi group - Dr. Nase gives an excellent description of flushing mechanisms in the group highlights - check it out if you haven't yet. Histamines are one of a number of imflammatory chemicals made by a class of immune cells that reside in the connective tissues of the body (including the skin). When you or your skin are traumatized or exposed to allergens the mast cells " degranulate " , releasing those histamines into the tissues. The histamines then help activate a generalized immmune response called inflammation. Antihistamines work by preventing mast cells from releasing their annoying chemical mediators. There are a host of other chemicals that seem to trigger inflammation, some carried by cells circulating in the blood and some made by cells fixed in the skin - perhaps this is why antihistamines alone do not help everyone. It depends on the very specific triggers and cells activated by your triggers. I have personally been thrilled to discover your group and to learn about zyrtec - it has helped me tremendously. oh - tried AR cream and sadly could not tolerate it - I can't take sulfa drugs and apparetly am allergic to sulfur - major pimply rash over entire face, neck ane even hands. Purple emu graciously refunded my monies. Very nice people. Quote Link to comment Share on other sites More sharing options...
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