Re: Dr. Krigsman Research article colon/intestinal OT sort of

[Guest guest]

To Everyone:

na, my daughter was in this study. She is the child with the

juvenile polyps that Dr. Krigsman found. Since being on this diet

now for 165 days, since December 26, 2003, na has gained 6 lbs,

grew 4 inches, her speech shot through the roof, her hair color and

texture has changed, her sensory issues are dissipating, the OCD is

disappearing, she just read her first sentence about 5 weeks ago and

slowly, but surely, her cognitive thought is coming.

I offer this information to you as encouragement! Stay with this

diet. Also, na is now just down to taking several things daily

including enzymes, folic acid, B-6 cream rubbed into her body, SCD

vitamin, quercatin, allergy nose drops made for her and a b-12 shot

everyother day! This beats the 33 some odd supplements she had taken

before, the 46 rounds of chelation, 9 rounds of IVIG and all the

other things that have been tried. Also the best part, she is not

taking any medications, everything is natural

Keep plugging!

Jimmy

Father of na, almost 8 yrs old (SCD Diet 165 days)

> I found this on the web, and I am sure many of you know about this

> already, as it is a few years old, but just thought it was

> interesting, related to the colon/intestinal problems.

>

> Tina SCD 2 months with family

>

>

> http://www.house.gov/reform/healthcareissues.htm

> Testimony before Congressional Oversight Committee on Autism and

> Immunization

> by Arthur Krigsman MD

>

> Mr. Chairman and members of the committee: This testimony

represents

> the scientific findings of data accumulated over the past year and

a

> half from autistic children during the course of standard

evaluations

> of their gastrointestinal symptoms. This testimony should in no way

> be taken as anti-vaccine. Children in my pediatric practice

continue

> to receive all vaccinations in accordance with the guidelines set

> forth by the American Academy of Pediatrics. The observations

> expressed herein are my own, and do not represent the opinions of

any

> institution, organization, clinic, or medical practice with which I

> may be associated.

>

> My involvement with autistic children began approximately one and a

> half years ago. At that time, I was approached by a colleague who

was

> caring for a large number of autistic patients. He observed that a

> large proportion of these patients suffered from chronic,

unexplained

> gastrointestinal symptoms and that these symptoms were a source of

> great anxiety to the parents. I agreed to evaluate them, and my

> findings are detailed below. The evaluations undertaken were

standard

> textbook evaluations of children with chronic diarrhea,

constipation,

> and abdominal pain, uninfluenced by the fact that these children

were

> autistic.

>

> Patient Population

>

> Our experience consists of a total of 43 consecutive children aged2-

> 10 years of age. Most were referred by private practitioners but

many

> were self referred after much frustration with their children's

> ongoing discomfort. 42patients had received a diagnosis of either

> autistic disorder or autistic spectrum disorder by a pediatric

> neurologist or developmental pediatrician. Many children had

received

> independent confirmation from a second or even a third pediatric

> specialist. In no instance was the diagnosis disputed by a second

> specialist. The remaining patient carried a diagnosis of Aspergers

> syndrome.

>

> The majority of patients had a clear history of developmental

> regression. Specifically, these children developed in an entirely

> normal fashion for the first 12-18 months. They typically had a

> vocabulary of 15-25 words, maintained normal eye contact, were

> playful and interactive, and were not overly irritable. At some

point

> during this age interval of 12-18months, they had either a

> precipitous or gradual decline in all the above mentioned

> developmental markers, and this was accompanied by the appearance

of

> typical autistic behaviors, stimming, and bouts of unexplained

> irritability. In some patients, verbal stagnation, but not

regression

> occurred. However, in these patients, clear regression was seen in

> the interactive and social skills of the children.

>

> The majority of patients are from the northeastern United States.

The

> ratio of males to females was 7:1.

>

> Symptomatology

>

> The most common gastrointestinal symptom noted by the parents was

> diarrhea. In some children, the diarrhea took the form of a soupy

> liquid thatoccurred4 to 7 times per day and would frequently leak

> from the child's diaper. However, the majority of parents reported

a

> stool frequency of 1-3 per day with a consistency of mashed

potatoes.

> The stool is particularly malodorous, and usually contains pieces

of

> undigested foods. Irritability is often noted just prior to the

bowel

> movement.

>

> Constipation is another frequent complaint, consisting of bowel

> movements every 3-6 days and typically accompanied by great

> irritability upon passage of the stool. The consistency of the

passed

> stool was not overly hard, suggesting that these children are

> actually withholding stool and not truly constipated in the strict

> sense of the term. This constipation is often accompanied by

> abdominal distension and flatulence. Most patients experienced

> periods of diarrhea alternating with periods of constipation.

>

> Abdominal pain is another frequent complaint. Most of these

children

> are poorly communicative, and parents often rely on body language

> cues in determining that their child is experiencing abdominal

pain.

> Children often drop unexpectedly to the floor howling and

screaming.

> This often lasts for up to half an hour. Many children clutch their

> abdomen and bend over. Some assume a fetal position on the bed or

> floor, and others take the parents hand and rub their abdomen.

>

> Finally, we have noticed that most regressive autistic children

show

> poor growth, with the majority falling in the lower 10th %tile

weight

> forage. Interestingly, there does not seem to be a concomitant

> percentile deficit in height for age.

>

> Evaluation

>

> All children underwent initial evaluation of their gastrointestinal

> symptoms. This included a thorough history and physical exam,

> complete blood count with platelets, erythrocyte sedimentation

rate,

> serum chemistries, celiac antibody panel with serum IgA,

inflammatory

> bowel disease serology, and stool examination for ova and

parasites,

> culture, and occult blood. The patients diet was thoroughly

reviewed

> to assure that it did not contain excessive nonabsorbed

carbohydrates

> or fruit juices. Therapeutic alterations in the diet were

undertaken,

> including the removal of all gluten and casein containing foods.

> Medications and supplements were reviewed to assure that they did

not

> contribute to the symptoms.

>

> The evaluation above invariably did not lead to a diagnosis and

> patients then underwent colonoscopy. Upper endoscopy was performed

> only if pain was a predominant complaint or if celiac disease was

> strongly suspected.

>

> Findings

>

> The above images depict the terminal ileum in two patients. They

are

> representative of the gross endoscopic findings of 90% of these

> patients in whom the lymphoid nodules of the terminal ileum were

> found to be markedly enlarged. This is in agreement with the

> previously published findings of Dr. Wakefield in which a similar

> proportion of patients were found to have abnormal lymphonodular

> hyperplasia of the terminal ileum.

>

> The second significant finding in our series was on histologic

> evaluation of the biopsy specimens. The results are summarized

below.

>

> % patients with colitis

> 28/43

> 65%

>

> % patients with active colitis

> 22/43

> 51%

>

> % patients with chronic colitis

> 17/43

> 40%

>

> % patients with eosinophilic colitis

> 3/43

> 7%

>

> % LNH (macro) of terminal ileum

> 36/40

> 90%

>

> % neither active, chronic, nor eosinophilic

> 15/43

> 35%

>

> Colitis was determined as per the report of the institutional

> pathologist. The interpretation of whether the degree of

inflammation

> represented true pathologic inflammation versus a normal variant

was

> subject to the personal experience of the individual pathologist

and

> was not subjected to auniform rating system.

>

> The patterns of inflammation were patchy and unpredictable in any

> given patient, but overall were noted in all parts of the colon and

> terminal ileum. Although the table above lists chronic and active

> colitis separately, most patients with colitis had both chronic and

> active inflammation. Most patients had at least 3-4 distinct areas

of

> histologic inflammation, with an equal number of biopsies that were

> histologically normal. The intensity of the inflammatory lesions

> varied as well, with many being subtle and somewhat focal, and

others

> being more marked and diffuse. The latter included areas of

> cryptitis, crypt abscess, ulcerations, and dense inflammatory

> infiltration. One patient was found to have an inflammatory polyp.

> Most significantly, these findings were consistent and seen

> repeatedly amongst the majority of patients.

>

> In regards to the last group of patients in the table above, it

> should be noted that although the histology did not reveal

pathologic

> colonic inflammation, the majority of these patients were found to

> have a heavy and diffuse lymphoid hyperplasia of the colon

> (macroscopic and microscopic), signifying an activation of the

> colon's internal immune system.

>

> Conclusion

>

> In a series of 43 autistic children, mostly regressive, with

chronic

> gastrointestinal symptoms, the majority were found to have

pathologic

> inflammation of the colon and terminal ileum. 90% had pathologic

> lymphonodular hyperplasia of the terminal ileum. Moreover, the

> findings were similar and consistent from patient to patient within

> the affected group.

>

> Questions

>

> 1) Does autistic colitis occur equally in regressive vs. non-

> regressive autism?

>

> 2) Do differences in growth exist between the colitis and non-

colitis

> group?

>

> 3) Do differences in growth exist between the regressive vs. non-

> regressive group?

>

> 4) In a retrospective analysis of growth, will onset of growth

> failure coincide with the onset of regressive behaviors?

[Guest guest]

This is Great News! I am so happy for you and your family. This is

very encouraging for the rest of us.

I'd be curious to know if there was any emphasis placed on bringing

her Essential Fatty Acids back into balance before or during the

165 day SCD program.

I'm also wondering how she did during the winter months when I

presume there was less sunlight (Vitamin D) available.

Thanks.

Kathy H.

SCD day 93, 10 & 8

In pecanbread , " jjjbardwil111990 "

<jjjbardwil111990@y...> wrote:

> To Everyone:

>

> na, my daughter was in this study. She is the child with the

> juvenile polyps that Dr. Krigsman found. Since being on this diet

> now for 165 days, since December 26, 2003, na has gained 6

lbs,

> grew 4 inches, her speech shot through the roof, her hair color

and

> texture has changed, her sensory issues are dissipating, the OCD

is

> disappearing, she just read her first sentence about 5 weeks ago

and

> slowly, but surely, her cognitive thought is coming.

>

> I offer this information to you as encouragement! Stay with this

> diet. Also, na is now just down to taking several things

daily

> including enzymes, folic acid, B-6 cream rubbed into her body, SCD

> vitamin, quercatin, allergy nose drops made for her and a b-12

shot

> everyother day! This beats the 33 some odd supplements she had

taken

> before, the 46 rounds of chelation, 9 rounds of IVIG and all the

> other things that have been tried. Also the best part, she is not

> taking any medications, everything is natural

>

> Keep plugging!

>

> Jimmy

> Father of na, almost 8 yrs old (SCD Diet 165 days)

>

>

>

>

>

> > I found this on the web, and I am sure many of you know about

this

> > already, as it is a few years old, but just thought it was

> > interesting, related to the colon/intestinal problems.

> >

> > Tina SCD 2 months with family

> >

> >

> > http://www.house.gov/reform/healthcareissues.htm

> > Testimony before Congressional Oversight Committee on Autism and

> > Immunization

> > by Arthur Krigsman MD

> >

> > Mr. Chairman and members of the committee: This testimony

> represents

> > the scientific findings of data accumulated over the past year

and

> a

> > half from autistic children during the course of standard

> evaluations

> > of their gastrointestinal symptoms. This testimony should in no

way

> > be taken as anti-vaccine. Children in my pediatric practice

> continue

> > to receive all vaccinations in accordance with the guidelines

set

> > forth by the American Academy of Pediatrics. The observations

> > expressed herein are my own, and do not represent the opinions

of

> any

> > institution, organization, clinic, or medical practice with

which I

> > may be associated.

> >

> > My involvement with autistic children began approximately one

and a

> > half years ago. At that time, I was approached by a colleague

who

> was

> > caring for a large number of autistic patients. He observed that

a

> > large proportion of these patients suffered from chronic,

> unexplained

> > gastrointestinal symptoms and that these symptoms were a source

of

> > great anxiety to the parents. I agreed to evaluate them, and my

> > findings are detailed below. The evaluations undertaken were

> standard

> > textbook evaluations of children with chronic diarrhea,

> constipation,

> > and abdominal pain, uninfluenced by the fact that these children

> were

> > autistic.

> >

> > Patient Population

> >

> > Our experience consists of a total of 43 consecutive children

aged2-

> > 10 years of age. Most were referred by private practitioners but

> many

> > were self referred after much frustration with their children's

> > ongoing discomfort. 42patients had received a diagnosis of

either

> > autistic disorder or autistic spectrum disorder by a pediatric

> > neurologist or developmental pediatrician. Many children had

> received

> > independent confirmation from a second or even a third pediatric

> > specialist. In no instance was the diagnosis disputed by a

second

> > specialist. The remaining patient carried a diagnosis of

Aspergers

> > syndrome.

> >

> > The majority of patients had a clear history of developmental

> > regression. Specifically, these children developed in an

entirely

> > normal fashion for the first 12-18 months. They typically had a

> > vocabulary of 15-25 words, maintained normal eye contact, were

> > playful and interactive, and were not overly irritable. At some

> point

> > during this age interval of 12-18months, they had either a

> > precipitous or gradual decline in all the above mentioned

> > developmental markers, and this was accompanied by the

appearance

> of

> > typical autistic behaviors, stimming, and bouts of unexplained

> > irritability. In some patients, verbal stagnation, but not

> regression

> > occurred. However, in these patients, clear regression was seen

in

> > the interactive and social skills of the children.

> >

> > The majority of patients are from the northeastern United

States.

> The

> > ratio of males to females was 7:1.

> >

> > Symptomatology

> >

> > The most common gastrointestinal symptom noted by the parents

was

> > diarrhea. In some children, the diarrhea took the form of a

soupy

> > liquid thatoccurred4 to 7 times per day and would frequently

leak

> > from the child's diaper. However, the majority of parents

reported

> a

> > stool frequency of 1-3 per day with a consistency of mashed

> potatoes.

> > The stool is particularly malodorous, and usually contains

pieces

> of

> > undigested foods. Irritability is often noted just prior to the

> bowel

> > movement.

> >

> > Constipation is another frequent complaint, consisting of bowel

> > movements every 3-6 days and typically accompanied by great

> > irritability upon passage of the stool. The consistency of the

> passed

> > stool was not overly hard, suggesting that these children are

> > actually withholding stool and not truly constipated in the

strict

> > sense of the term. This constipation is often accompanied by

> > abdominal distension and flatulence. Most patients experienced

> > periods of diarrhea alternating with periods of constipation.

> >

> > Abdominal pain is another frequent complaint. Most of these

> children

> > are poorly communicative, and parents often rely on body

language

> > cues in determining that their child is experiencing abdominal

> pain.

> > Children often drop unexpectedly to the floor howling and

> screaming.

> > This often lasts for up to half an hour. Many children clutch

their

> > abdomen and bend over. Some assume a fetal position on the bed

or

> > floor, and others take the parents hand and rub their abdomen.

> >

> > Finally, we have noticed that most regressive autistic children

> show

> > poor growth, with the majority falling in the lower 10th %tile

> weight

> > forage. Interestingly, there does not seem to be a concomitant

> > percentile deficit in height for age.

> >

> > Evaluation

> >

> > All children underwent initial evaluation of their

gastrointestinal

> > symptoms. This included a thorough history and physical exam,

> > complete blood count with platelets, erythrocyte sedimentation

> rate,

> > serum chemistries, celiac antibody panel with serum IgA,

> inflammatory

> > bowel disease serology, and stool examination for ova and

> parasites,

> > culture, and occult blood. The patients diet was thoroughly

> reviewed

> > to assure that it did not contain excessive nonabsorbed

> carbohydrates

> > or fruit juices. Therapeutic alterations in the diet were

> undertaken,

> > including the removal of all gluten and casein containing foods.

> > Medications and supplements were reviewed to assure that they

did

> not

> > contribute to the symptoms.

> >

> > The evaluation above invariably did not lead to a diagnosis and

> > patients then underwent colonoscopy. Upper endoscopy was

performed

> > only if pain was a predominant complaint or if celiac disease

was

> > strongly suspected.

> >

> > Findings

> >

> > The above images depict the terminal ileum in two patients. They

> are

> > representative of the gross endoscopic findings of 90% of these

> > patients in whom the lymphoid nodules of the terminal ileum were

> > found to be markedly enlarged. This is in agreement with the

> > previously published findings of Dr. Wakefield in which a

similar

> > proportion of patients were found to have abnormal lymphonodular

> > hyperplasia of the terminal ileum.

> >

> > The second significant finding in our series was on histologic

> > evaluation of the biopsy specimens. The results are summarized

> below.

> >

> > % patients with colitis

> > 28/43

> > 65%

> >

> > % patients with active colitis

> > 22/43

> > 51%

> >

> > % patients with chronic colitis

> > 17/43

> > 40%

> >

> > % patients with eosinophilic colitis

> > 3/43

> > 7%

> >

> > % LNH (macro) of terminal ileum

> > 36/40

> > 90%

> >

> > % neither active, chronic, nor eosinophilic

> > 15/43

> > 35%

> >

> > Colitis was determined as per the report of the institutional

> > pathologist. The interpretation of whether the degree of

> inflammation

> > represented true pathologic inflammation versus a normal variant

> was

> > subject to the personal experience of the individual pathologist

> and

> > was not subjected to auniform rating system.

> >

> > The patterns of inflammation were patchy and unpredictable in

any

> > given patient, but overall were noted in all parts of the colon

and

> > terminal ileum. Although the table above lists chronic and

active

> > colitis separately, most patients with colitis had both chronic

and

> > active inflammation. Most patients had at least 3-4 distinct

areas

> of

> > histologic inflammation, with an equal number of biopsies that

were

> > histologically normal. The intensity of the inflammatory lesions

> > varied as well, with many being subtle and somewhat focal, and

> others

> > being more marked and diffuse. The latter included areas of

> > cryptitis, crypt abscess, ulcerations, and dense inflammatory

> > infiltration. One patient was found to have an inflammatory

polyp.

> > Most significantly, these findings were consistent and seen

> > repeatedly amongst the majority of patients.

> >

> > In regards to the last group of patients in the table above, it

> > should be noted that although the histology did not reveal

> pathologic

> > colonic inflammation, the majority of these patients were found

to

> > have a heavy and diffuse lymphoid hyperplasia of the colon

> > (macroscopic and microscopic), signifying an activation of the

> > colon's internal immune system.

> >

> > Conclusion

> >

> > In a series of 43 autistic children, mostly regressive, with

> chronic

> > gastrointestinal symptoms, the majority were found to have

> pathologic

> > inflammation of the colon and terminal ileum. 90% had pathologic

> > lymphonodular hyperplasia of the terminal ileum. Moreover, the

> > findings were similar and consistent from patient to patient

within

> > the affected group.

> >

> > Questions

> >

> > 1) Does autistic colitis occur equally in regressive vs. non-

> > regressive autism?

> >

> > 2) Do differences in growth exist between the colitis and non-

> colitis

> > group?

> >

> > 3) Do differences in growth exist between the regressive vs. non-

> > regressive group?

> >

> > 4) In a retrospective analysis of growth, will onset of growth

> > failure coincide with the onset of regressive behaviors?

[Guest guest]

Kathy:

After being on the DAN protocol for 2 years, we naturally agonized

over removing the supplements. In fact, one day I actually added

back in the Omega 3s by itself, as a result, na was, " off " for

about 5 hours until the Omega left her system. To verify for us it

was the Omegas, we kept the diet the exact same the next day with no

Omega 3s. We have not looked back since. All my Omega3s went to the

dog as treats.

Regarding sunlight and Vitamin D. This is a good observation by you!

We did not changes. However, last night I clipped her nails and I

see calcium deposits for the first time. I also see a, " white " line

designating the end of the nail and beginning of skin being

protected. This is calcium that was not there previously. I believe

calcium indicates high level of vitamin D. Follow the protocol and do

the goats milk yoghurt. It works! Your child will gain the calcium.

Ramp up slowly follow the book. Do not go to fast or give too much

even over time. Too much of the, " good " bugs throws off the flora

in the colon as well.

My thoughts are this: Eat Goat Yogurt, Spring is here, so make them

run around like kids!. Make them sweat and have fun like healthy

kids outdoors. When a kids runs around and plays, they are healthy,

happy and forget their troubles!

Incidentally, the calcium I noticed must have just been deposited in

her finger nails over the last 2 weeks! This is a major change

indicating absorption finally!!!!!

> > > I found this on the web, and I am sure many of you know about

> this

> > > already, as it is a few years old, but just thought it was

> > > interesting, related to the colon/intestinal problems.

> > >

> > > Tina SCD 2 months with family

> > >

> > >

> > > http://www.house.gov/reform/healthcareissues.htm

> > > Testimony before Congressional Oversight Committee on Autism

and

> > > Immunization

> > > by Arthur Krigsman MD

> > >

> > > Mr. Chairman and members of the committee: This testimony

> > represents

> > > the scientific findings of data accumulated over the past year

> and

> > a

> > > half from autistic children during the course of standard

> > evaluations

> > > of their gastrointestinal symptoms. This testimony should in no

> way

> > > be taken as anti-vaccine. Children in my pediatric practice

> > continue

> > > to receive all vaccinations in accordance with the guidelines

> set

> > > forth by the American Academy of Pediatrics. The observations

> > > expressed herein are my own, and do not represent the opinions

> of

> > any

> > > institution, organization, clinic, or medical practice with

> which I

> > > may be associated.

> > >

> > > My involvement with autistic children began approximately one

> and a

> > > half years ago. At that time, I was approached by a colleague

> who

> > was

> > > caring for a large number of autistic patients. He observed

that

> a

> > > large proportion of these patients suffered from chronic,

> > unexplained

> > > gastrointestinal symptoms and that these symptoms were a source

> of

> > > great anxiety to the parents. I agreed to evaluate them, and my

> > > findings are detailed below. The evaluations undertaken were

> > standard

> > > textbook evaluations of children with chronic diarrhea,

> > constipation,

> > > and abdominal pain, uninfluenced by the fact that these

children

> > were

> > > autistic.

> > >

> > > Patient Population

> > >

> > > Our experience consists of a total of 43 consecutive children

> aged2-

> > > 10 years of age. Most were referred by private practitioners

but

> > many

> > > were self referred after much frustration with their children's

> > > ongoing discomfort. 42patients had received a diagnosis of

> either

> > > autistic disorder or autistic spectrum disorder by a pediatric

> > > neurologist or developmental pediatrician. Many children had

> > received

> > > independent confirmation from a second or even a third

pediatric

> > > specialist. In no instance was the diagnosis disputed by a

> second

> > > specialist. The remaining patient carried a diagnosis of

> Aspergers

> > > syndrome.

> > >

> > > The majority of patients had a clear history of developmental

> > > regression. Specifically, these children developed in an

> entirely

> > > normal fashion for the first 12-18 months. They typically had a

> > > vocabulary of 15-25 words, maintained normal eye contact, were

> > > playful and interactive, and were not overly irritable. At some

> > point

> > > during this age interval of 12-18months, they had either a

> > > precipitous or gradual decline in all the above mentioned

> > > developmental markers, and this was accompanied by the

> appearance

> > of

> > > typical autistic behaviors, stimming, and bouts of unexplained

> > > irritability. In some patients, verbal stagnation, but not

> > regression

> > > occurred. However, in these patients, clear regression was seen

> in

> > > the interactive and social skills of the children.

> > >

> > > The majority of patients are from the northeastern United

> States.

> > The

> > > ratio of males to females was 7:1.

> > >

> > > Symptomatology

> > >

> > > The most common gastrointestinal symptom noted by the parents

> was

> > > diarrhea. In some children, the diarrhea took the form of a

> soupy

> > > liquid thatoccurred4 to 7 times per day and would frequently

> leak

> > > from the child's diaper. However, the majority of parents

> reported

> > a

> > > stool frequency of 1-3 per day with a consistency of mashed

> > potatoes.

> > > The stool is particularly malodorous, and usually contains

> pieces

> > of

> > > undigested foods. Irritability is often noted just prior to the

> > bowel

> > > movement.

> > >

> > > Constipation is another frequent complaint, consisting of bowel

> > > movements every 3-6 days and typically accompanied by great

> > > irritability upon passage of the stool. The consistency of the

> > passed

> > > stool was not overly hard, suggesting that these children are

> > > actually withholding stool and not truly constipated in the

> strict

> > > sense of the term. This constipation is often accompanied by

> > > abdominal distension and flatulence. Most patients experienced

> > > periods of diarrhea alternating with periods of constipation.

> > >

> > > Abdominal pain is another frequent complaint. Most of these

> > children

> > > are poorly communicative, and parents often rely on body

> language

> > > cues in determining that their child is experiencing abdominal

> > pain.

> > > Children often drop unexpectedly to the floor howling and

> > screaming.

> > > This often lasts for up to half an hour. Many children clutch

> their

> > > abdomen and bend over. Some assume a fetal position on the bed

> or

> > > floor, and others take the parents hand and rub their abdomen.

> > >

> > > Finally, we have noticed that most regressive autistic children

> > show

> > > poor growth, with the majority falling in the lower 10th %tile

> > weight

> > > forage. Interestingly, there does not seem to be a concomitant

> > > percentile deficit in height for age.

> > >

> > > Evaluation

> > >

> > > All children underwent initial evaluation of their

> gastrointestinal

> > > symptoms. This included a thorough history and physical exam,

> > > complete blood count with platelets, erythrocyte sedimentation

> > rate,

> > > serum chemistries, celiac antibody panel with serum IgA,

> > inflammatory

> > > bowel disease serology, and stool examination for ova and

> > parasites,

> > > culture, and occult blood. The patients diet was thoroughly

> > reviewed

> > > to assure that it did not contain excessive nonabsorbed

> > carbohydrates

> > > or fruit juices. Therapeutic alterations in the diet were

> > undertaken,

> > > including the removal of all gluten and casein containing

foods.

> > > Medications and supplements were reviewed to assure that they

> did

> > not

> > > contribute to the symptoms.

> > >

> > > The evaluation above invariably did not lead to a diagnosis and

> > > patients then underwent colonoscopy. Upper endoscopy was

> performed

> > > only if pain was a predominant complaint or if celiac disease

> was

> > > strongly suspected.

> > >

> > > Findings

> > >

> > > The above images depict the terminal ileum in two patients.

They

> > are

> > > representative of the gross endoscopic findings of 90% of these

> > > patients in whom the lymphoid nodules of the terminal ileum

were

> > > found to be markedly enlarged. This is in agreement with the

> > > previously published findings of Dr. Wakefield in which a

> similar

> > > proportion of patients were found to have abnormal

lymphonodular

> > > hyperplasia of the terminal ileum.

> > >

> > > The second significant finding in our series was on histologic

> > > evaluation of the biopsy specimens. The results are summarized

> > below.

> > >

> > > % patients with colitis

> > > 28/43

> > > 65%

> > >

> > > % patients with active colitis

> > > 22/43

> > > 51%

> > >

> > > % patients with chronic colitis

> > > 17/43

> > > 40%

> > >

> > > % patients with eosinophilic colitis

> > > 3/43

> > > 7%

> > >

> > > % LNH (macro) of terminal ileum

> > > 36/40

> > > 90%

> > >

> > > % neither active, chronic, nor eosinophilic

> > > 15/43

> > > 35%

> > >

> > > Colitis was determined as per the report of the institutional

> > > pathologist. The interpretation of whether the degree of

> > inflammation

> > > represented true pathologic inflammation versus a normal

variant

> > was

> > > subject to the personal experience of the individual

pathologist

> > and

> > > was not subjected to auniform rating system.

> > >

> > > The patterns of inflammation were patchy and unpredictable in

> any

> > > given patient, but overall were noted in all parts of the colon

> and

> > > terminal ileum. Although the table above lists chronic and

> active

> > > colitis separately, most patients with colitis had both chronic

> and

> > > active inflammation. Most patients had at least 3-4 distinct

> areas

> > of

> > > histologic inflammation, with an equal number of biopsies that

> were

> > > histologically normal. The intensity of the inflammatory

lesions

> > > varied as well, with many being subtle and somewhat focal, and

> > others

> > > being more marked and diffuse. The latter included areas of

> > > cryptitis, crypt abscess, ulcerations, and dense inflammatory

> > > infiltration. One patient was found to have an inflammatory

> polyp.

> > > Most significantly, these findings were consistent and seen

> > > repeatedly amongst the majority of patients.

> > >

> > > In regards to the last group of patients in the table above, it

> > > should be noted that although the histology did not reveal

> > pathologic

> > > colonic inflammation, the majority of these patients were found

> to

> > > have a heavy and diffuse lymphoid hyperplasia of the colon

> > > (macroscopic and microscopic), signifying an activation of the

> > > colon's internal immune system.

> > >

> > > Conclusion

> > >

> > > In a series of 43 autistic children, mostly regressive, with

> > chronic

> > > gastrointestinal symptoms, the majority were found to have

> > pathologic

> > > inflammation of the colon and terminal ileum. 90% had

pathologic

> > > lymphonodular hyperplasia of the terminal ileum. Moreover, the

> > > findings were similar and consistent from patient to patient

> within

> > > the affected group.

> > >

> > > Questions

> > >

> > > 1) Does autistic colitis occur equally in regressive vs. non-

> > > regressive autism?

> > >

> > > 2) Do differences in growth exist between the colitis and non-

> > colitis

> > > group?

> > >

> > > 3) Do differences in growth exist between the regressive vs.

non-

> > > regressive group?

> > >

> > > 4) In a retrospective analysis of growth, will onset of growth

> > > failure coincide with the onset of regressive behaviors?

[Guest guest]

Are you saying you believe the Omega fatty acids are a problem?? If you do

not feel safe to try the goats yogurt??How about just using probiotic from

custom probiotics. What is this about the vitamin D. Im confussed. Can you

help me understand what you are saying helped or hurt???