- thiamine deficiency carnosine/thiamine connection?

[Guest guest]

I did a lot of research on this when my kids were tiny. Both of them are

very low in histamine. Both of their grandmothers have/had low stomach

acid/pernicious anemia. I had done some research(we are talking at least 15

years ago, from memory) that showed that children of alcoholics(my father

was) are often thiamine deficient, as are their children. Mike's B vitamins

have been tested every 6 months since age two, and the one vitamin we had to

be particularly careful about supplementing is thiamine. The only B

vitamins he tolerated forever(until Ojibwa tea) that DIDN'T induce petit

mals were B6, B12, and thiamine. My " normal " daughter has put herself on

carnosine and B6 at college. She found herself spacing out in long science

labs. She has always talked way to fast for most people's taste lol. When

she's taking these supplements, she's literally a different person. Her

ability to train for her sport (running) without injury has improved

dramatically, and her lap times " on " and " off " are measureably different.

As for Mike, he does well alternating carnosine/carnitine. He can't take

either every day. He definitely feels " poisoned " if he gets too much

carnosine. If he starts getting skin fungal infections, carnitine will

clear it. I have wondered if transdermsl TTFD would " fix " some of his

chemistry-but I'm a little afraid to try it. -what do you think?

[ ] Are we recognizing thiamine deficiency and is

there a carnosine/thiamine connection?

> Listmates,

>

> Carnosine is made up of histidine and beta-alanine. Taking histidine can

> (apparently) be helpful if you are thiamine-deficient. I would just love

> to hear any comments about this association based on your own experiences!

>

> The activity of histidine carboxylase is this:

>

> L-histidine <-> Histamine + CO2 (cofactors = P5P or pyruvate)

>

> Note this line: Either activation or inhibition of the central

> histaminergic system resulted in muricidal suppression in thiamine

> deficient rats. That's pretty amazing, and maybe should make us think

that

> if anti-histamines are working (and maybe if carnosine is working????),

> maybe the REAL problem is thiamine deficiency! I would REALLY like to

hear

>

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