Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 , I know you’re very busy, but when you have some time (no hurry), could you please tell me what you think of the possibility of taking L-Tyrosine for fatigue? Thank you, Barb in Texas BMC Gastroenterol. 2005 Mar 24. The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis. ter Borg PC, Fekkes D, Vrolijk JM, van Buuren HR. Depart Gastroenterology & Hepatology, Erasmus MC, Rotterdam, The Netherlands. BACKGROUND: In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify abnormalities in AA patterns and to define their relation with fatigue. METHODS: Plasma concentrations of tyrosine, tryptophan, phenylalanine, valine, leucine and isoleucine were determined in plasma of patients with PBC (n = 45), PSC (n = 27), chronic hepatitis C (n = 22) and healthy controls (n = 73). Fatigue and quality of life were quantified using the Fisk fatigue severity scale, a visual analogue scale and the SF-36. RESULTS: Valine, isoleucine, leucine were significantly decreased in PBC and PSC. Tyrosine and phenylalanine were increased (p < 0.0002) and tryptophan decreased (p < 0.0001) in PBC. In PBC, but not in PSC, a significant inverse relation between tyrosine concentrations and fatigue and quality of life was found. Patients without fatigue and with good quality of life had increased tyrosine concentrations compared to fatigued patients. Multivariate analysis indicated that this relation was independent from disease activity or severity or presence of cirrhosis. CONCLUSION: In patients with PBC and PSC, marked abnormalities in plasma AA patterns occur. Normal tyrosine concentrations, compared to increased concentrations, may be associated with fatigue and diminished quality of life. PMID: 15790420 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 Hi Barb; I'd be a bit reluctant to recommend taking tyrosine for fatigue, based on results in this paper. I think it is much too early to tell whether taking a tyrosine supplement would do any good in PSC. It's possible that the measured differences in amino acid levels seen in PBC and PSC patients and controls may be a reflection of alterations in levels of neurologically active amines derived from tryptophan or tyrosine (e.g. 5-hydroxytryptamine and serotonin derived from tryptophan, and/or di- hydroxyphenylalanine (L-DOPA) and dopamine derived from tyrosine). Best regards, Dave (father of (20); PSC 07/03; UC 08/03) > could you please tell me what you think of the possibility of taking L-Tyrosine for fatigue? Thank you, Barb in Texas Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2006 Report Share Posted March 9, 2006 Tyrosine needs to be taken first thing in the morning on an empty stomach. If you take it too late in the day it will keep you awake as it is brain stimulating. This is from taking it myself due to low thryroid. Diane PS I would begin on a low dose say 100mg and then work up to 500mg. > >Reply-To: >To: < > >Subject: A ? for >Date: Thu, 9 Mar 2006 11:07:03 -0600 > >, > >I know you're very busy, but when you have some time (no hurry), could >you please tell me what you think of the possibility of taking >L-Tyrosine for fatigue? > >Thank you, >Barb in Texas > > >B <javascript:AL_get(this,%20'jour',%20'BMC%20Gastroenterol.');> MC >Gastroenterol. 2005 Mar 24. > > >The relation between plasma tyrosine concentration and fatigue in >primary biliary cirrhosis and primary sclerosing cholangitis. > > ><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >l=pubmed_Abstract & term=%22ter+Borg+PC%22%5BAuthor%5D> ter Borg PC, ><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >l=pubmed_Abstract & term=%22Fekkes+D%22%5BAuthor%5D> Fekkes D, ><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >l=pubmed_Abstract & term=%22Vrolijk+JM%22%5BAuthor%5D> Vrolijk JM, ><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >l=pubmed_Abstract & term=%22van+Buuren+HR%22%5BAuthor%5D> van Buuren HR. > >Depart Gastroenterology & Hepatology, Erasmus MC, Rotterdam, The >Netherlands. > >BACKGROUND: In primary biliary cirrhosis (PBC) and primary sclerosing >cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino >acid (AA) patterns have been implicated in the development of fatigue in >several non-hepatological conditions but for PBC and PSC no data are >available. This study aimed to identify abnormalities in AA patterns and >to define their relation with fatigue. METHODS: Plasma concentrations of >tyrosine, tryptophan, phenylalanine, valine, leucine and isoleucine were >determined in plasma of patients with PBC (n = 45), PSC (n = 27), >chronic hepatitis C (n = 22) and healthy controls (n = 73). Fatigue and >quality of life were quantified using the Fisk fatigue severity scale, a >visual analogue scale and the SF-36. RESULTS: Valine, isoleucine, >leucine were significantly decreased in PBC and PSC. Tyrosine and >phenylalanine were increased (p < 0.0002) and tryptophan decreased (p < >0.0001) in PBC. In PBC, but not in PSC, a significant inverse relation >between tyrosine concentrations and fatigue and quality of life was >found. Patients without fatigue and with good quality of life had >increased tyrosine concentrations compared to fatigued patients. >Multivariate analysis indicated that this relation was independent from >disease activity or severity or presence of cirrhosis. CONCLUSION: In >patients with PBC and PSC, marked abnormalities in plasma AA patterns >occur. Normal tyrosine concentrations, compared to increased >concentrations, may be associated with fatigue and diminished quality of >life. > >PMID: 15790420 [PubMed - indexed for MEDLINE] > _________________________________________________________________ Express yourself instantly with MSN Messenger! Download today - it's FREE! http://messenger.msn.click-url.com/go/onm00200471ave/direct/01/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2006 Report Share Posted March 10, 2006 -----Original Message----- I'd be a bit reluctant to recommend taking tyrosine for fatigue, based on results in this paper. Thank you , I was hoping…….oh well, back to the drawing board. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2006 Report Share Posted March 11, 2006 Dianne-Have you had positive results from taking Tyrosine? Did a Dr approve your strategy? Denny A ? for >>Date: Thu, 9 Mar 2006 11:07:03 -0600 >> >>, >> >>I know you're very busy, but when you have some time (no hurry), could >>you please tell me what you think of the possibility of taking >>L-Tyrosine for fatigue? >> >>Thank you, >>Barb in Texas >> >> >>B <javascript:AL_get(this,%20'jour',%20'BMC%20Gastroenterol.');> MC >>Gastroenterol. 2005 Mar 24. >> >> >>The relation between plasma tyrosine concentration and fatigue in >>primary biliary cirrhosis and primary sclerosing cholangitis. >> >> >><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >>l=pubmed_Abstract & term=%22ter+Borg+PC%22%5BAuthor%5D> ter Borg PC, >><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >>l=pubmed_Abstract & term=%22Fekkes+D%22%5BAuthor%5D> Fekkes D, >><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >>l=pubmed_Abstract & term=%22Vrolijk+JM%22%5BAuthor%5D> Vrolijk JM, >><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itoo >>l=pubmed_Abstract & term=%22van+Buuren+HR%22%5BAuthor%5D> van Buuren HR. >> >>Depart Gastroenterology & Hepatology, Erasmus MC, Rotterdam, The >>Netherlands. >> >>BACKGROUND: In primary biliary cirrhosis (PBC) and primary sclerosing >>cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino >>acid (AA) patterns have been implicated in the development of fatigue in >>several non-hepatological conditions but for PBC and PSC no data are >>available. This study aimed to identify abnormalities in AA patterns and >>to define their relation with fatigue. METHODS: Plasma concentrations of >>tyrosine, tryptophan, phenylalanine, valine, leucine and isoleucine were >>determined in plasma of patients with PBC (n = 45), PSC (n = 27), >>chronic hepatitis C (n = 22) and healthy controls (n = 73). Fatigue and >>quality of life were quantified using the Fisk fatigue severity scale, a >>visual analogue scale and the SF-36. RESULTS: Valine, isoleucine, >>leucine were significantly decreased in PBC and PSC. Tyrosine and >>phenylalanine were increased (p < 0.0002) and tryptophan decreased (p < >>0.0001) in PBC. In PBC, but not in PSC, a significant inverse relation >>between tyrosine concentrations and fatigue and quality of life was >>found. Patients without fatigue and with good quality of life had >>increased tyrosine concentrations compared to fatigued patients. >>Multivariate analysis indicated that this relation was independent from >>disease activity or severity or presence of cirrhosis. CONCLUSION: In >>patients with PBC and PSC, marked abnormalities in plasma AA patterns >>occur. Normal tyrosine concentrations, compared to increased >>concentrations, may be associated with fatigue and diminished quality of >>life. >> >>PMID: 15790420 [PubMed - indexed for MEDLINE] >> > > _________________________________________________________________ > Express yourself instantly with MSN Messenger! Download today - it's FREE! > http://messenger.msn.click-url.com/go/onm00200471ave/direct/01/ > > > > > Quote Link to comment Share on other sites More sharing options...
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