Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 Thanks to you and everyone who replied to this. .....laurie bject: Re: [ ] Epsom Salt Capsules Doug and Laurie, Sorry, I miised this earlier. Oral supplementation of magnesium sulfate is problematic because it can cause diarrhea and upset the tummy, but the biggest reason is this: if we are like rats (and we probably are in this regards), then there is a signal initiated from the gut when the concentration of the sulfate in the gut increases that tells the kidneys to dump sulfate. This occurs transcriptionally by having the kidneys downregulate sulfate reabsorption, so a whole lot more sulfate ends up being dumped into the urine. The effect in lab animals is so large that they have measured more sulfate being lost than there was in the original oral dose. This is why you will hear the transdermal route is preferred. But, since the half-life of sulfate in the blood is about 4-9 hours, a more frequent schedule of dosing it transdermally is probably a good idea in someone sulfate deficient. Actually, years ago I made the capsules myself for my father, but I was never impressed with what they did for him, but I WAS impressed for what the transdermal solution did for him. He had Alzheimers disease. Owens Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 13, 2003 Report Share Posted May 13, 2003 Where do you get a transdermal solution? Do you mix it yourself? Would epsom salt baths be just as effective? Kim --- In , " Doug & Laurie " <aphase@s...> wrote: > Thanks to you and everyone who replied to this. > ....laurie > > > bject: Re: [ ] Epsom Salt Capsules > Doug and Laurie, > Sorry, I miised this earlier. Oral supplementation of magnesium sulfate is > problematic because it can cause diarrhea and upset the tummy, but the > biggest reason is this: if we are like rats (and we probably are in this > regards), then there is a signal initiated from the gut when the > concentration of the sulfate in the gut increases that tells the kidneys to > dump sulfate. This occurs transcriptionally by having the kidneys > downregulate sulfate reabsorption, so a whole lot more sulfate ends up > being dumped into the urine. The effect in lab animals is so large that > they have measured more sulfate being lost than there was in the original > oral dose. This is why you will hear the transdermal route is > preferred. But, since the half-life of sulfate in the blood is about 4-9 > hours, a more frequent schedule of dosing it transdermally is probably a > good idea in someone sulfate deficient. > Actually, years ago I made the capsules myself for my father, but I was > never impressed with what they did for him, but I WAS impressed for what > the transdermal solution did for him. He had Alzheimers disease. > Owens > > Quote Link to comment Share on other sites More sharing options...
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