Re: The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

[Guest guest]

I know that the study was of Israeli's, but my brother and my brother-in-law both have Crohn's and both were born in January. Of course we also have a family tendency toward AI.

Kathy

The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

Yehuda ChowersShmuel OdesYoram BujanoverRami EliakimSimon Bar Meir Avidan

Abstract

OBJECTIVE:

The main objective is to study whether the month of birth is associated with the development of Crohn's disease (CD) in the Israeli Jewish population.

BACKGROUND:

It was suggested that perinatal exposure to infectious agents may have a role in the pathogenesis of CD. Due to the seasonal nature of some infections, a linkage between birth dates and a risk to develop CD would support such a hypothesis. Previous studies that addressed this question were conducted in Europe and differed in their findings.

METHODS:

Birth dates of 844 Jewish ulcerative colitis (UC) and CD patients from three medical centers representing the north, central, and the south of Israel were compared with the monthly rates of birth during the same period of time. The standard incidence ratio was used to define the risk to develop either disease according to the month of birth. The Score method was used for the evaluation of seasonality trends.

RESULTS:

Birth during the winter period in Israel was associated with increased risk to develop CD, whereas birth during the spring was associated with a reduced risk. The Score method for seasonality showed a significant peak during winter time in these patients (z = 2.02, p= 0.021). No such seasonal variation was noted for UC patients.

CONCLUSIONS:

A seasonal pattern was observed in the risk to develop CD but not UC. The findings may support the involvement of environmental factors in the pathogenesis of CD.

(Am J Gastroenterol 2004;99:1-3)Please visit our website at:http://ACES_Autoimmune.tripod.com

[Guest guest]

There's a major confound here: Births are not distributed

equally throughout the year; they peak in spring and fall. This

paper didn't take that effect into account.

Owens

[Guest guest]

I was born in September, but also have other AI diseases.

At the moment, got the flu....

MSN: sarah_krein@...

Yahoo Messenger: s_krein@...

Always with a listening ear... feel free to add me!!

-----Original Message-----From: Kathy Sent: Wednesday, October 06, 2004 10:28 PMTo: autoimmune-ills Subject: Re: The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

I know that the study was of Israeli's, but my brother and my brother-in-law both have Crohn's and both were born in January. Of course we also have a family tendency toward AI.

Kathy

The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

Yehuda ChowersShmuel OdesYoram BujanoverRami EliakimSimon Bar Meir Avidan

Abstract

OBJECTIVE:

The main objective is to study whether the month of birth is associated with the development of Crohn's disease (CD) in the Israeli Jewish population.

BACKGROUND:

It was suggested that perinatal exposure to infectious agents may have a role in the pathogenesis of CD. Due to the seasonal nature of some infections, a linkage between birth dates and a risk to develop CD would support such a hypothesis. Previous studies that addressed this question were conducted in Europe and differed in their findings.

METHODS:

Birth dates of 844 Jewish ulcerative colitis (UC) and CD patients from three medical centers representing the north, central, and the south of Israel were compared with the monthly rates of birth during the same period of time. The standard incidence ratio was used to define the risk to develop either disease according to the month of birth. The Score method was used for the evaluation of seasonality trends.

RESULTS:

Birth during the winter period in Israel was associated with increased risk to develop CD, whereas birth during the spring was associated with a reduced risk. The Score method for seasonality showed a significant peak during winter time in these patients (z = 2.02, p= 0.021). No such seasonal variation was noted for UC patients.

CONCLUSIONS:

A seasonal pattern was observed in the risk to develop CD but not UC. The findings may support the involvement of environmental factors in the pathogenesis of CD.

(Am J Gastroenterol 2004;99:1-3)Please visit our website at:http://ACES_Autoimmune.tripod.com Please visit our website at:http://ACES_Autoimmune.tripod.com

[Guest guest]

Right, but if they are higher in the spring and the fall, and winter births have more Crohn's patient's...wouldn't that make the percentage even higher?

Kathy

Re: The Month of Birth is Linked to the Risk of Crohn's Disease in the Israeli Population

There's a major confound here: Births are not distributedequally throughout the year; they peak in spring and fall. Thispaper didn't take that effect into account.OwensPlease visit our website at:http://ACES_Autoimmune.tripod.com